WormBase Tree Display for Gene: WBGene00000923

WBGene00000923 SMap: S_parent: Sequence: K07H8
  Identity: Version: 2
    Name: CGC_name: daf-31 Paper_evidence: WBPaper00045886
          Person_evidence: WBPerson521
      Sequence_name: K07H8.3
      Molecular_name: K07H8.3
        K07H8.3.1
        CE18023
      Other_name: CELE_K07H8.3 Accession_evidence: NDB BX284604
      Public_name: daf-31
    DB_info: Database: NDB locus_tag CELE_K07H8.3
        Panther gene CAEEL|Gene=K07H8.3|UniProtKB=O61219
          family PTHR23091
        NCBI gene 177622
        RefSeq protein NM_068991.7
        KEGG KEGG_id 2.3.1.255
        NemaPath KEGG_id 2.3.1.255
        SwissProt UniProtAcc O61219
        TREEFAM TREEFAM_ID TF300078
        UniProt_GCRP UniProtAcc O61219
        OMIM gene 300013
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 27 Oct 2014 07:59:13 WBPerson2970 Event: Acquires_merge: WBGene00019505
              Name_change: Sequence_name: K07H8.3
      Acquires_merge: WBGene00019505
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: daf
    Allele (20)
    Legacy_information: [C.elegansII] m655: nonconditional constitutive formation of abnormal dauer-like larvae; 3 molts; dauer-like pharynx;does not form true dauer in pheromone. ES2. NA1. [DR]
    Strain: WBStrain00036587
    RNASeq_FPKM (74)
    GO_annotation (18)
    Contained_in_operon: CEOP4280
    Ortholog (31)
    Paralog: WBGene00015074 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018238 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018831 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022394 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: daf-31 encodes an ortholog of the ARrest-Defective-1 protein (ARD1) that is the catalytic subunit of the major N alpha-AcetylTransferase (NatA), a heterodimeric complex that is responsible for the cotranslational N-terminal acetylation of protein substrates; loss of daf-31 activity results in constitutive formation of dauer-like larvae and fat accumulation, indicating that DAF-31 is required for dauer larval development and metabolism; in addition, daf-31 activity is required for resumption of reproductive development upon removal of dauer-inducing conditions; overexpression of DAF-31 in a daf-2 mutant background results in increased DAF-16-dependent longevity indicating a role for DAF-31 in regulation of adult lifespan, as well; DAF-31 overexpression also results in increased DAF-16 transcriptional activity, independent of an effect on DAF-16 nuclear localization; a daf-31::gfp promoter fusion is expressed from the L1 larval stage through adulthood and found in neurons, pharynx, intestine, and hypodermal cells. Paper_evidence: WBPaper00045886
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 27 Oct 2014 00:00:00
      Automated_description: Predicted to enable peptide-glutamate-alpha-N-acetyltransferase activity and peptide-serine-alpha-N-acetyltransferase activity. Involved in dauer exit; determination of adult lifespan; and multicellular organism reproduction. Predicted to be part of NatA complex. Expressed in hypodermal cell and neurons. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Is an ortholog of human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit) and NAA11 (N-alpha-acetyltransferase 11, NatA catalytic subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111799 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18704)
      DOID:0050781 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18704)
  Molecular_info: Corresponding_CDS: K07H8.3
    Corresponding_transcript: K07H8.3.1
    Other_sequence (53)
    Associated_feature: WBsf997182
      WBsf228651
  Experimental_info: RNAi_result: WBRNAi00034095 Inferred_automatically: RNAi_primary
      WBRNAi00050205 Inferred_automatically: RNAi_primary
      WBRNAi00061525 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram131
      Expr6354
      Expr12014
      Expr1021969
      Expr1038429
      Expr1153903
      Expr2010774
      Expr2029011
    Drives_construct: WBCnstr00003767
      WBCnstr00019994
      WBCnstr00020146
      WBCnstr00037197
    Construct_product: WBCnstr00020146
      WBCnstr00037197
    Microarray_results (20)
    Expression_cluster (128)
    Interaction: WBInteraction000524539
      WBInteraction000552456
      WBInteraction000552704
      WBInteraction000568779
      WBInteraction000578499
  Map_info: Map: IV Position: 3.7047
    Positive: Positive_clone: K07H8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00012530
    WBPaper00019517
    WBPaper00038491
    WBPaper00041831
    WBPaper00045886
    WBPaper00048627
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene