WormBase Tree Display for Gene: WBGene00002974
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WBGene00002974 | SMap | S_parent | Sequence | F58D2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lev | ||||||
Reference_allele | WBVar00143038 | ||||||
Allele (119) | |||||||
Legacy_information | e211 (pka tmr-1) : almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. NA > 10 (x22 etc.). Also two rare semidominant alleles with uncoordinated phenotype x21 : (uncoordinated Egl-c ME3) x63. | ||||||
See also e211, e289 | |||||||
[C.elegansII] e211 : (pka tmr-1) almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. OA>10: x22, e289, x577 etc. Also two rare semidominant alleles with uncoordinated phenotype, x21 (uncoordinated Egl-c, ME3), x63. Cloned: corresponds to acr-1, encoding subunit of nicotinic acetylcholine receptor. [Lewis et al. 1980, 1987; ZZ; MQ] | |||||||
Strain | WBStrain00003893 | ||||||
WBStrain00030691 | |||||||
WBStrain00033031 | |||||||
WBStrain00040924 | |||||||
WBStrain00000741 | |||||||
WBStrain00004129 | |||||||
WBStrain00004573 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (37) | |||||||
Ortholog (46) | |||||||
Paralog (100) | |||||||
Structured_description | Concise_description | lev-1 encodes a non-alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, regulation of egg-laying behavior, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3; a LEV-1::GFP fusion protein is expressed in all body wall muscle cells and a subset of ventral cord motor neurons. | Paper_evidence | WBPaper00000031 | |||
WBPaper00004660 | |||||||
WBPaper00005223 | |||||||
WBPaper00024530 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 20 Jun 2008 00:00:00 | ||||||
Automated_description | Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in regulation of egg-laying behavior; regulation of locomotion; and transmembrane transport. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:3905 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||
DOID:5409 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||
DOID:3083 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||
DOID:0110663 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) | ||||
DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||
DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||
DOID:0050742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||
DOID:0110662 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) | ||||
Molecular_info | Corresponding_CDS | F09E8.7a | |||||
F09E8.7b | |||||||
Corresponding_transcript | F09E8.7a.1 | ||||||
F09E8.7b.1 | |||||||
Other_sequence (14) | |||||||
Associated_feature | WBsf652327 | ||||||
WBsf668451 | |||||||
WBsf668452 | |||||||
WBsf668453 | |||||||
WBsf668454 | |||||||
WBsf998352 | |||||||
WBsf998353 | |||||||
WBsf1018500 | |||||||
WBsf231093 | |||||||
Experimental_info | RNAi_result | WBRNAi00102763 | Inferred_automatically | RNAi_primary | |||
WBRNAi00012987 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00001574 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00066400 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00044139 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00066521 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr3395 | ||||||
Expr3708 | |||||||
Expr3709 | |||||||
Expr4346 | |||||||
Expr1027358 | |||||||
Expr1031374 | |||||||
Expr1148107 | |||||||
Expr2013085 | |||||||
Expr2031317 | |||||||
Drives_construct (12) | |||||||
Construct_product (14) | |||||||
Microarray_results (19) | |||||||
Expression_cluster (125) | |||||||
Interaction (25) | |||||||
Map_info | Map | IV | Position | 8.43149 | Error | 0.004865 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf27 | |||||
nDf28 | |||||||
sDf21 | |||||||
Positive_clone | F09E8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
JF#WA10 | |||||||
Mapping_data | 2_point | 228 | |||||
229 | |||||||
347 | |||||||
2726 | |||||||
4660 | |||||||
4661 | |||||||
4666 | |||||||
Multi_point (19) | |||||||
Pos_neg_data (11) | |||||||
Reference (112) | |||||||
Method | Gene |