WormBase Tree Display for Gene: WBGene00003001
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| WBGene00003001 | SMap | S_parent | Sequence | R107 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-12 | Person_evidence | WBPerson261 | |||||
| Sequence_name | R107.8 | ||||||||
| Molecular_name | R107.8 | ||||||||
| R107.8.1 | |||||||||
| CE00274 | |||||||||
| Other_name | CELE_R107.8 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | lin-12 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00089283 | ||||||||
| WBVar00089843 | |||||||||
| Allele (254) | |||||||||
| Possibly_affected_by | WBVar02157825 | ||||||||
| WBVar02157828 | |||||||||
| Legacy_information | Class 1 alleles (loss-of-function) n941 : abnormal vulva sterile small many lineage transformations; putative null. ES3 ME0. NA1. Class 2 alleles (gain-of-function) n137sd : adult hermaphrodite Muv many lineage transformations. ES3 ME1 (n137/+ ME3). NA sd > 15 (n177 etc. (resembles n137); n676 n302 n379 (these alleles have semidominant Vul phenotype probably less hypermorphic)). Also intragenic revertants of dominant alleles NA(ird) > 50 : most have Class 1 phenotype e.g. n137n720 n676n909amber (resemble n941); n137n460ts (wildtype at 25x Muv at 15x); many other non-null alleles with tissue-specific effects also Tcl-insertion null alleles. | ||||||||
| See also e1956, e1975, e1976, e1977, e1978, e1979, e2031, e2032, e2033, e2034, e2081, e2082, e2083, e2084, n137, n177, n302, n310, n311, n312, n313, n314, n315, n317, n379, n386, n427, n457, n460, n676, n700, n720, n721, n722, n723, n724, n725, n769, n862, n863, n865, n908, n909, n910, n911, n912, n913, n914, n915, n916, n917, n918, n919, n920, n921, n922, n925, n926, n928, n932, n933, n934, n936, n937, n939, n940, n941, n950, n951, n952, n1000, n1001, n1002, n1003, n1004, n1005, n1088, n1222, n1223, n1224, n1225, n1226, n1227, n1228, n1229, n1230, n1231, n1232, n1233, n1234, n1235, n1236, n1237, n1238, n1239, n1240, n1241, n1242, n1243, n1244, n1245, n1246, n1247, n1287, n1288, n1295, n1328 | |||||||||
| [C.elegansII] n941 : abnormal vulva, sterile small, many lineage transformations. ES3 ME0. Also gain-of-function alleles: n137sd : adult hermaphrodite Muv, many lineage transformations. ES3 ME1 (n137/+ ME3). OA>15(gf): n177 (resembles n137); n676, n302, n379 (these alleles have semidominant Vul phenotype, probably less hypermorphic)). Also intragenic revertants of dominant alleles OA>50 (ird): most have lf phenotype e.g. n137n720, n676n909amb (resemble n941), n137n460ts (wildtype at 25C, Muv at 15C); many other non-null alleles with tissue-specific effects, also Tcl-insertion null alleles.See also sel, lag, glp-1; Lag functions redundant with glp-1. Cloned: encodes 1429 aa protein, transmembrane receptor related to GLP-1, Drosophila Notch; 13 EGF-like repeats and other repeatsin extracellular domain, 6 ANK repeats in intracellular domain. Very extensive developmental and molecular analysis, many mutations sequenced. [Greenwald et al. 1983; Wilkinson et al. 1994; Wilkinson and Greenwald 1995; GS] | |||||||||
| Strain (40) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (59) | |||||||||
| Ortholog (50) | |||||||||
| Paralog | WBGene00000168 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00000792 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WBGene00001106 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00001609 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00010134 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | The lin-12 gene encodes a member of the Notch/LIN-12/glp-1 transmembrane receptor family that affects cell fate specification events during development, notably including the anchor cell, secondary vulval precursor cells, and the embryonic ABplp lineage; its expression is dynamic, including Z1.ppp and Z4.aaa, ABplaa descendants, ABplpa descendants, and the intestinal primordium. | Curator_confirmed | WBPerson567 | |||||
| Date_last_updated | 24 Jan 2005 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including egg-laying behavior; nematode larval development; and positive regulation of mesodermal cell fate specification. Located in apical plasma membrane and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including body wall muscle cell from M lineage; gonadal sheath cell; somatic nervous system; vulval cell; and vulval precursor cell. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); ductal carcinoma in situ; and hemangioblastoma. Is an ortholog of human NOTCH4 (notch receptor 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:10652 | |||||||
| Potential_model (12) | |||||||||
| Models_disease_asserted | WBDOannot00000651 | ||||||||
| Molecular_info | Corresponding_CDS | R107.8 | |||||||
| Corresponding_transcript | R107.8.1 | ||||||||
| Other_sequence | CBC12434_1 | ||||||||
| Dviv_isotig30054 | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info (10) | |||||||||
| Map_info | Map | III | Position | 0.136216 | Error | 0.003065 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf17 | |||||||
| Positive_clone | IG10A | ||||||||
| R107 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data (3) | |||||||||
| Landmark_gene | |||||||||
| Reference (701) | |||||||||
| Method | Gene |
