WormBase Tree Display for Gene: WBGene00003106

WBGene00003106 SMap: S_parent: Sequence: T27A1
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: mab
    Reference_allele: WBVar00143856
    Allele (135)
    Legacy_information: e1245 : male tail morphology and development grossly abnormal B lineage defective U and F lineages variably abnormal many males die or rupture during L4 molt. ES3 ME0. Hermaphrodite phenotype wildtype. NA1.
      See also e1245, e2410
      [C.elegansII] e1245amb : male tail morphology and development grossly abnormal, B lineage defective, resembles Y lineage; also probable F to U lineage transformation; many males die or rupture during L4 molt. e1245/Df similar. ES3 (male), ME0. Hermaphrodite grossly WT, sometimes constipated as a result of rectal abnormalities.rectal cells. OA2: e2410, e2376 (weaker allele). [Chisholm and Hodgkin 1989]
      [Woollard A] Predicted gene T27A1.6, encoding Brachury-like T-box (other name tbx-12)
    Strain: WBStrain00000301
      WBStrain00035311
      WBStrain00029688
      WBStrain00029830
      WBStrain00004480
      WBStrain00004574
      WBStrain00051009
      WBStrain00052002
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog (37)
    Paralog (21)
    Structured_description: Concise_description: mab-9 encodes a member of the T-box family of transcriptional regulators containing a 200-amino acid T-box DNA-binding domain most similar to mouse Brachyury; mab-9 is involved in hindgut and male tail development, specifically affecting the fate of two posterior blast cells in the hindgut, B and F; in the male this results in a grossly abnormal tail lacking spicules, and renders them incapable of mating; in the hermaphrodite this results in hindgut defects; mab-9 may also be part of a network of T-box genes that includes tbx-8, tbx-9 and vab-7 and is important for the correct patterning of posterior cells in the developing embryo; mab-9 mutations also affect backward locomotion as a result of motor neuron axon guidance defects; MAB-9 localizes to the nucleus of B and F and their descendents during development and is also detected in the nuclei of all embryonically derived motor neurons. Paper_evidence: WBPaper00003719
            WBPaper00003958
            WBPaper00004321
            WBPaper00005251
            WBPaper00024194
            WBPaper00031616
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 09 Oct 2008 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and post-embryonic hindgut morphogenesis. Located in nucleus. Expressed in several structures, including B.a; B.p; neurons; proctodeum; and rectal epithelial cell. Human ortholog(s) of this gene implicated in atrial heart septal defect 4; tetralogy of Fallot; and ventricular septal defect. Is an ortholog of human TBX20 (T-box transcription factor 20). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110109 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11598)
      DOID:1657 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11598)
      DOID:6419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11598)
      DOID:1682 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11598)
      DOID:1882 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11598)
  Molecular_info: Corresponding_CDS: T27A1.6
    Corresponding_transcript: T27A1.6.1
    Other_sequence (13)
    Associated_feature (12)
    Transcription_factor: WBTranscriptionFactor000681
  Experimental_info: RNAi_result: WBRNAi00093802 Inferred_automatically: RNAi_primary
      WBRNAi00027693 Inferred_automatically: RNAi_primary
      WBRNAi00115771 Inferred_automatically: RNAi_primary
      WBRNAi00093803 Inferred_automatically: RNAi_primary
      WBRNAi00054252 Inferred_automatically: RNAi_primary
      WBRNAi00001356 Inferred_automatically: RNAi_primary
      WBRNAi00022454 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00000439
      WBCnstr00000657
      WBCnstr00001121
      WBCnstr00001616
      WBCnstr00006320
      WBCnstr00012275
      WBCnstr00012831
      WBCnstr00013180
      WBCnstr00042600
    Construct_product: WBCnstr00000657
    Microarray_results (20)
    Expression_cluster (147)
    Interaction (44)
  Map_info: Map: II Position: -15.5963 Error: 0.000641
    Well_ordered
    Positive: Inside_rearr: nDf3
      Positive_clone: T27A1 Author_evidence: (cosmid rescue,
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 652
        653
        6131
      Multi_point: 564
        565
        1672
        1674
        3677
        4154
        5512
      Pos_neg_data: 2613
        2614
        2615
    Landmark_gene
  Reference (63)
  Method: Gene