WormBase Tree Display for Gene: WBGene00003401
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| WBGene00003401 | SMap | S_parent | Sequence | F43C1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name (5) | |||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mpk | ||||||||
| Allele (160) | |||||||||
| Possibly_affected_by | WBVar02154083 | ||||||||
| WBVar02156990 | |||||||||
| WBVar02156991 | |||||||||
| WBVar02156992 | |||||||||
| WBVar02156993 | |||||||||
| Legacy_information | [Wu Y, Han M] all alleles has Egl phenotype, partial larval lethal. lineage defects was observed for ku1 and ku30 | ||||||||
| [C.elegansII] ku1 : (pka sur-1) suppresses activated ras(let-60(gf), variable Vul, cs Egl, rod-like early larval lethality phenotypes; impenetrant defects in P6.p lineage.OA>10: ku30 (lineage defects), ku33, ku34, ku38(all Egl), n2521 (activated ras suppressor, normal lineage alone, mosaic analysis indicates cell autonomy), pk79tci etc. Cloned: Encodes 375 aa predicted protein, 75-80% identical to mammalian MPK, closest to ERK2 subfamily. [Lackner et al. 1994; Wu and Han 1994; MH; MT; SD] | |||||||||
| Strain (20) | |||||||||
| Component_of_genotype | WBGenotype00000087 | ||||||||
| WBGenotype00000088 | |||||||||
| WBGenotype00000109 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (49) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | mpk-1 encodes a mitogen-activated protein (MAP) kinase an ERK ortholog functioning in vulval cell fate specification, cell migration/guidance, defense against bacterial infection, and other processes; in proximal germline, sperm-dependent physiological MPK-1 activation results in phosphorylation based inactivation of NOS-3, FEM-CUL-2-mediated degradation of TRA-1 and the promotion of membrane organization during oogenesis; mpk-1 affect LET-60(Ras)-mediated induction of vulval cell fates, larval viability, morphology of the male spicules; both LIN-1 and LIN-31 act genetically downstream of mpk-1 with respect to vulval induction; MPK-1 is necessary for pachytene cell organization; mpk-1 mutants display germ cells arrested in pachytene; MPK-1 is necessary for the progression from distal to proximal pachytene; MPK-1 promotes pachytene progression, with the rise in dpMPK-1 triggering a transition from a distal pachytene to a proximal pachytene subtype; MPK-1 functions in the germline for meiotic prophase progression and gametogenesis; MPK-1 ERK signaling is necessary for the male germ cell fate; MPK-1 ERK has the nonessential function of promoting the proliferative germ cell fate; mpk-1 acts in combination with mek-2 to permit germ cell exit from the pachytene stage of first meiotic prophase; MPK-1 activation is temporally/spatially dynamic compared to relatively constant levels of total MPK-1. | Paper_evidence | WBPaper00001869 | |||||
| WBPaper00001870 | |||||||||
| WBPaper00003177 | |||||||||
| WBPaper00028788 | |||||||||
| WBPaper00031318 | |||||||||
| WBPaper00038448 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson12884 | |||||||||
| Date_last_updated | 25 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables MAP kinase activity. Involved in several processes, including determination of adult lifespan; intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Expressed in F cell; U cell; germ line; gonad; and oocyte. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Noonan syndrome 13; carcinoma (multiple); and childhood pilocytic astrocytoma. Is an ortholog of human MAPK1 (mitogen-activated protein kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00060633 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jun 2021 00:00:00 | ||||||||
| Potential_model (17) | |||||||||
| Models_disease_asserted | WBDOannot00000958 | ||||||||
| WBDOannot00000959 | |||||||||
| WBDOannot00000965 | |||||||||
| WBDOannot00000966 | |||||||||
| Molecular_info | Corresponding_CDS | F43C1.2a | |||||||
| F43C1.2b | |||||||||
| Corresponding_transcript | F43C1.2a.1 | ||||||||
| F43C1.2a.2 | |||||||||
| F43C1.2b.1 | |||||||||
| Other_sequence (109) | |||||||||
| Associated_feature (27) | |||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | III | Position | -3.65654 | Error | 0.031007 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C49A12 | |||||||
| DD7 | |||||||||
| F43C1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| R74 | |||||||||
| SD#2 | |||||||||
| Mapping_data | Multi_point | 3205 | |||||||
| 3206 | |||||||||
| 2223 | |||||||||
| 2224 | |||||||||
| 2225 | |||||||||
| 2226 | |||||||||
| 4053 | |||||||||
| 5012 | |||||||||
| Pos_neg_data | 7418 | ||||||||
| Reference (369) | |||||||||
| Picture | WBPicture0000013080 | ||||||||
| WBPicture0000013091 | |||||||||
| Remark | at -4.05 but being swapped with unc-103 at -3.93 [jah/sdm 5/99 | ||||||||
| Method | Gene |
