WormBase Tree Display for Gene: WBGene00003598
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| WBGene00003598 | SMap | S_parent | Sequence | F26F4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nhl-2 | Person_evidence | WBPerson599 | |||||
| Sequence_name | F26F4.7 | ||||||||
| Molecular_name | F26F4.7 | ||||||||
| F26F4.7.1 | |||||||||
| CE29291 | |||||||||
| Other_name | CELE_F26F4.7 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | nhl-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhl | ||||||||
| Allele (63) | |||||||||
| Possibly_affected_by | WBVar02152916 | ||||||||
| WBVar02152917 | |||||||||
| Strain | WBStrain00031646 | ||||||||
| WBStrain00040305 | |||||||||
| WBStrain00052162 | |||||||||
| WBStrain00054867 | |||||||||
| In_cluster | conserved_miRNA_siRNA_cluster | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP3232 | ||||||||
| Ortholog (36) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | nhl-2 encodes one of five C. elegans proteins that contain TRIM (tripartite-containing motif; RING, B-box, coiled-coil) and NHL (NCL-1, HT2A and LIN-41) domains; NHL-2 functions together with CGH-1 and in association with the miRSC complex to regulate the efficacy of microRNA-target interactions and hence, gene regulation, during postembryonic development; in addition, nhl-2 mutations suppress embryonic lethal mutations in par-2, suggesting that nhl-2 also plays a role in establishing embryonic polarity; NHL-2 physically interacts with CGH-1 and localizes to cytoplasmic P bodies, mRNA processing bodies. | Paper_evidence | WBPaper00032055 | |||||
| WBPaper00032974 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 18 Nov 2009 00:00:00 | ||||||||
| Automated_description | Enables DEAD/H-box RNA helicase binding activity. Involved in positive regulation of development, heterochronic; protein localization to cell cortex; and regulation of establishment of cell polarity. Located in P granule and P-body. Expressed in several structures, including germ line. Is an ortholog of human TRIM45 (tripartite motif containing 45). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F26F4.7 | |||||||
| Corresponding_transcript | F26F4.7.1 | ||||||||
| Other_sequence | CR12142 | ||||||||
| CBC07343_1 | |||||||||
| Tcol_isotig20046 | |||||||||
| JI165920.1 | |||||||||
| CRC10775_1 | |||||||||
| Associated_feature (12) | |||||||||
| Transcription_factor | WBTranscriptionFactor000390 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00065854 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00013966 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005266 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00045680 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094667 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013967 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090602 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076349 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001424 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr5880 | ||||||||
| Expr8339 | |||||||||
| Expr8579 | |||||||||
| Expr13295 | |||||||||
| Expr14255 | |||||||||
| Expr1020010 | |||||||||
| Expr1031647 | |||||||||
| Expr1149591 | |||||||||
| Expr2013995 | |||||||||
| Expr2032235 | |||||||||
| Drives_construct | WBCnstr00004170 | ||||||||
| WBCnstr00013377 | |||||||||
| WBCnstr00036014 | |||||||||
| Construct_product | WBCnstr00013377 | ||||||||
| WBCnstr00036014 | |||||||||
| Regulate_expr_cluster | WBPaper00055971:nhl-2(ok818)_20C_downregulated | ||||||||
| WBPaper00055971:nhl-2(ok818)_20C_upregulated | |||||||||
| WBPaper00055971:nhl-2(ok818)_25C_downregulated | |||||||||
| WBPaper00055971:nhl-2(ok818)_25C_upregulated | |||||||||
| Antibody | WBAntibody00001443 | ||||||||
| WBAntibody00001741 | |||||||||
| WBAntibody00002859 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (138) | |||||||||
| Interaction (81) | |||||||||
| WBProcess | WBbiopr:00000082 | ||||||||
| Map_info | Map | III | Position | -2.40668 | Error | 0.000908 | |||
| Positive | Positive_clone | F26F4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5269 | |||||||
| Pseudo_map_position | |||||||||
| Reference (44) | |||||||||
| Remark | Sequence connection from [Slack FJ], 02/06/10 krb | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
