WormBase Tree Display for Gene: WBGene00003930
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| WBGene00003930 | SMap | S_parent | Sequence | ZK1058 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pat-3 | Person_evidence | WBPerson1562 | |||||
| Sequence_name | ZK1058.2 | ||||||||
| Molecular_name | ZK1058.2 | ||||||||
| ZK1058.2.1 | |||||||||
| CE01102 | |||||||||
| Other_name | INTB/1 | ||||||||
| epi-2 | CGC_data_submission | ||||||||
| CELE_ZK1058.2 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | pat-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pat | ||||||||
| Allele (92) | |||||||||
| Possibly_affected_by | WBVar02152922 | ||||||||
| WBVar02153159 | |||||||||
| WBVar02153160 | |||||||||
| WBVar02153161 | |||||||||
| Legacy_information | [Gettner S] pat-3 mutation affects gene for beta integrin, next to dpy-27 | ||||||||
| [Williams BD] Severe Pat phenotype. st564 weaker allele. | |||||||||
| [C.elegansII] st423 : severe Pat phenotype, disrupted myofilament lattice. OA>8: st564 (weaker allele), st423, st552, st564, rh54 (embryonic lethal, mosaic analysis indicates autonomous defects in cell attachment, morphogenesis, etc.),rh151 (sterile), rh96 (mild; short excretory canals, varible Mig defects). Cloned: 3kb transcript, encodes beta integrin. [Williams and Waterston 1994; Gettner et al. 1995; CF; NJ; RW] | |||||||||
| Strain | WBStrain00002787 | ||||||||
| WBStrain00033527 | |||||||||
| WBStrain00040278 | |||||||||
| WBStrain00047295 | |||||||||
| WBStrain00047217 | |||||||||
| WBStrain00047296 | |||||||||
| WBStrain00047390 | |||||||||
| WBStrain00047373 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (54) | |||||||||
| Contained_in_operon | CEOP3864 | ||||||||
| Ortholog (59) | |||||||||
| Paralog | WBGene00015472 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | pat-3 encodes the C. elegans beta-integrin subunit; pat-3 is an essential gene that is required for muscle cell attachment to the overlying hypodermis and for normal muscle filament assembly and function; in addition, pat-3 is required for normal axon guidance and for ovulation; antibody staining reveals that PAT-3 is expressed in body wall muscle as well as in the anal depressor, sphincter, intestinal, vulval, and uterine muscles and the somatic gonad; PAT-3 localizes to dense bodies, M-lines, and intercellular borders. | Paper_evidence | WBPaper00001894 | |||||
| WBPaper00002179 | |||||||||
| WBPaper00004882 | |||||||||
| WBPaper00005218 | |||||||||
| WBPaper00027099 | |||||||||
| WBPaper00029138 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 27 Feb 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable integrin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cellular component organization; and regulation of locomotion. Located in several cellular components, including contractile fiber; focal adhesion; and lateral plasma membrane. Part of integrin complex. Expressed in several structures, including GABAergic neurons; egg-laying apparatus; enteric muscle; gonad; and vulval precursor cell. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); and lung carcinoma (multiple). Is an ortholog of human ITGB1 (integrin subunit beta 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00038447 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Oct 2022 00:00:00 | ||||||||
| Potential_model (26) | |||||||||
| Models_disease_in_annotation | WBDOannot00001339 | ||||||||
| Molecular_info | Corresponding_CDS | ZK1058.2 | |||||||
| Corresponding_transcript | ZK1058.2.1 | ||||||||
| Other_sequence (79) | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info | RNAi_result (61) | ||||||||
| Expr_pattern (21) | |||||||||
| Drives_construct (20) | |||||||||
| Construct_product (16) | |||||||||
| Antibody | WBAntibody00000035 | ||||||||
| WBAntibody00000094 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction (242) | |||||||||
| Anatomy_function | WBbtf0442 | ||||||||
| WBbtf0449 | |||||||||
| WBbtf0451 | |||||||||
| WBbtf0610 | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | III | Position | -4.22486 | |||||
| Well_ordered | |||||||||
| Positive | Positive_clone | CF#BI2.3 | |||||||
| ZK1058 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 2104 | |||||||
| 2105 | |||||||||
| 2106 | |||||||||
| 2108 | |||||||||
| 3015 | |||||||||
| 4052 | |||||||||
| 4053 | |||||||||
| 4791 | |||||||||
| 5662 | |||||||||
| Pos_neg_data | 6110 | ||||||||
| Reference (146) | |||||||||
| Remark | Data extracted from Williams & Waterston 1994 | ||||||||
| ZK1058.7 removed from Sequence connection. There is no longer a .7 predicted gene.[sdm 05/00] | |||||||||
| [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-4.24293) | |||||||||
| Method | Gene |
