WormBase Tree Display for Gene: WBGene00004323
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| WBGene00004323 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K08H10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | rde-1 | Person_evidence | WBPerson419 | |||||
| Sequence_name | K08H10.7 | ||||||||
| Molecular_name | K08H10.7 | ||||||||
| K08H10.7.1 | |||||||||
| CE28243 | |||||||||
| Other_name | CELE_K08H10.7 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | rde-1 | ||||||||
| DB_info | Database | AceView | gene | 5K468 | |||||
| WormQTL | gene | WBGene00004323 | |||||||
| WormFlux | gene | WBGene00004323 | |||||||
| NDB | locus_tag | CELE_K08H10.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004323|UniProtKB=G5EEH0 | |||||||
| family | PTHR22891 | ||||||||
| NCBI | gene | 179393 | |||||||
| RefSeq | protein | NM_171525.7 | |||||||
| TREEFAM | TREEFAM_ID | TF354206 | |||||||
| TrEMBL | UniProtAcc | G5EEH0 | |||||||
| UniProt_GCRP | UniProtAcc | G5EEH0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rde | ||||||||
| Allele (68) | |||||||||
| Possibly_affected_by | WBVar02157814 | ||||||||
| WBVar02158858 | |||||||||
| Strain (44) | |||||||||
| In_cluster | conserved_RDE-1_cluster | ||||||||
| conserved_miRNA_siRNA_cluster | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Contained_in_operon | CEOP5240 | ||||||||
| Ortholog (32) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | rde-1 encodes a member of the Argonaute (SGO) and PIWI family of proteins; rde-1 activity is required for RNA-mediated interference (RNAi); specifically, in RNAi induced by exogenous dsRNA, RDE-1 acts as the siRNA acceptor for siRNAs produced by DCR-1-mediated cleavage; subsequently, RDE-1 directs a multi-protein complex to homologous mRNA targets to trigger their destabilization and degradation; RDE-1 physically interacts with the dsRNA binding protein RDE-4 in vivo and RDE-1 activity is also required for accumulation of dsRNA bound to RDE-4. | Paper_evidence | WBPaper00003711 | |||||
| WBPaper00004920 | |||||||||
| WBPaper00005368 | |||||||||
| WBPaper00032504 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Jan 2015 00:00:00 | ||||||||
| Automated_description | Enables DEAD/H-box RNA helicase binding activity; RNA endonuclease activity, producing 5'-phosphomonoesters; and siRNA binding activity. Involved in obsolete conversion of ds siRNA to ss siRNA involved in RNA interference; regulatory ncRNA-mediated heterochromatin formation; and regulatory ncRNA-mediated post-transcriptional gene silencing. Part of RISC complex. Expressed in male. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K08H10.7 | |||||||
| Corresponding_CDS_history | K08H10.7:wp52 | ||||||||
| Corresponding_transcript | K08H10.7.1 | ||||||||
| Other_sequence | AF180730 | ||||||||
| FG621042.1 | |||||||||
| CBC11944_1 | |||||||||
| Dviv_isotig16445 | |||||||||
| Oden_isotig20026 | |||||||||
| Dviv_isotig16444 | |||||||||
| Acan_isotig10451 | |||||||||
| Associated_feature | WBsf652956 | ||||||||
| WBsf234307 | |||||||||
| Experimental_info (11) | |||||||||
| Map_info (4) | |||||||||
| Reference (203) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
