WormBase Tree Display for Gene: WBGene00006868
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WBGene00006868 | SMap | S_parent | Sequence | M03A1 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | vab | ||||||
Reference_allele | WBVar00142901 | ||||||
Allele (418) | |||||||
Legacy_information | e2 : notched head variable dystrophy of ventral cephalic region especially in L1; penetrance < 70%. ES3/0 ME3. NA8 (e1063 : penetrance 35%; e2027spo : penetrance > 90%). | ||||||
See also e2, e116, e118, e200, e699, e721, e1063, e2027 | |||||||
[C.elegansII] e2 : notched head, variable dystrophy of ventral cephalic region, especially in L1; penetrance < 70%. ES3/0 ME3. OA>10: e1063 (penetrance 35%), e2027spo (penetrance > 90%), e699 etc. [Brenner 1974; Lewis and Hodgkin 1979; CB; CZ] | |||||||
Strain (24) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (38) | |||||||
Ortholog (113) | |||||||
Paralog (69) | |||||||
Structured_description | Concise_description | vab-1 encodes an ephrin receptor; during development, vab-1 activity is required for neural and epithelial morphogenesis as well as for proper axon targeting and neuronal cell migration; in addition, VAB-1 functions as a major sperm protein receptor in a sperm-sensing control mechanism that regulates oocyte meiotic maturation; VAB-1::GFP reporters are expressed in neuronal cells and in oocytes and sheath cells of the proximal gonad. | Paper_evidence | WBPaper00003020 | |||
WBPaper00003843 | |||||||
WBPaper00005670 | |||||||
WBPaper00027013 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 28 Feb 2007 00:00:00 | ||||||
Automated_description | Enables ephrin receptor activity and protein domain specific binding activity. Involved in several processes, including cell development; embryonic morphogenesis; and regulation of axon guidance. Located in axon and plasma membrane. Expressed in several structures, including hypodermal cell; neuroblasts; neurons; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; aortic dissection; cataract 6 multiple types; and gastrointestinal system cancer (multiple). Is an ortholog of several human genes including EPHB1 (EPH receptor B1); EPHB2 (EPH receptor B2); and EPHB3 (EPH receptor B3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (14) | ||||||
Molecular_info | Corresponding_CDS | M03A1.1 | |||||
Corresponding_CDS_history | M03A1.1b:wp274 | ||||||
Corresponding_transcript | M03A1.1.1 | ||||||
Other_sequence (11) | |||||||
Associated_feature (54) | |||||||
Experimental_info | RNAi_result (27) | ||||||
Expr_pattern (16) | |||||||
Drives_construct | WBCnstr00000707 | ||||||
WBCnstr00006419 | |||||||
WBCnstr00009616 | |||||||
WBCnstr00018076 | |||||||
WBCnstr00034120 | |||||||
WBCnstr00042438 | |||||||
Construct_product (15) | |||||||
Antibody | WBAntibody00000876 | ||||||
WBAntibody00001049 | |||||||
WBAntibody00001576 | |||||||
WBAntibody00002037 | |||||||
WBAntibody00002313 | |||||||
Microarray_results (28) | |||||||
Expression_cluster (158) | |||||||
Interaction (248) | |||||||
Anatomy_function | WBbtf0217 | ||||||
WBbtf0220 | |||||||
WBProcess | WBbiopr:00000001 | ||||||
WBbiopr:00000068 | |||||||
WBbiopr:00000120 | |||||||
Map_info | Map | II | Position | -3.85469 | Error | 0.013028 | |
Well_ordered | |||||||
Positive | Inside_rearr | mDf14 | |||||
mDf15 | |||||||
Positive_clone | M03A1 | Person_evidence | WBPerson105 | ||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data (3) | |||||||
Reference (154) | |||||||
Method | Gene |