WormBase Tree Display for Gene: WBGene00001165

WBGene00001165 SMap: S_parent: Sequence: F56A11
  Identity: Version: 1
    Name: CGC_name: efn-4 Person_evidence: WBPerson893
      Sequence_name: F56A11.3
      Molecular_name: F56A11.3
        F56A11.3.1
        CE29503
      Other_name: mab-26
        CELE_F56A11.3 Accession_evidence: NDB BX284604
      Public_name: efn-4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: efn
    Allele (170)
    Legacy_information: [C.elegansII] bx80sd : fusions among all rays; also head, body and (especially) tail deformities; bx80/+ impenetrant R4 to R3 transformation. [Chow and Emmons 1994; EM]
    Strain: WBStrain00005372
      WBStrain00007176
      WBStrain00049265
      WBStrain00049276
    RNASeq_FPKM (74)
    GO_annotation (33)
    Ortholog: WBGene00059483 Caenorhabditis remanei From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00024824 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00146874 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00146524 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00133236 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      CBOVI.g11318 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3468 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g18952 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7028 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g7151 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g12733 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g12841 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g2348 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9366 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g12954 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-efn-4 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g7566 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01155.g18832 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_16352 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_014693 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02766 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_40114300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g9524 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00286612 Trichuris muris From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-990415-66 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-980526-186 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-001128-1 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-010618-2 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-011108-1 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1135 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-041007-5 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-100922-64 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060503-186 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3221 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3222 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3223 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3224 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3225 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3226 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      MGI:103236 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:102707 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      MGI:106644 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      MGI:106643 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      MGI:107444 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:620389 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:620388 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:620391 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:620390 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:1309497 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      RGD:1307808 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
    Paralog: WBGene00001163 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001164 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006869 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: efn-4 encodes a divergent member of the ephrin family of ligands; efn-4 is required for neuroblast migrations during closure of the ventral gastrulation cleft and subsequent epidermal morphogenesis, possibly functioning independently of EFN-1, EFN-2, EFN-3, and the VAB-1 receptor during morphogenesis; EFN-4 can interact weakly with VAB-1 in vitro; EFN-4 is expressed in neural and epidermal precursors at the 100-cell stage, in head neurons, pharyngeal cells, lateral and tail neurons, and in the ectoderm during epidermal enclosure. Paper_evidence: WBPaper00003865
            WBPaper00005631
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 23 Jul 2008 00:00:00
      Automated_description: Predicted to enable ephrin receptor binding activity. Involved in several processes, including embryonic morphogenesis; nematode male tail tip morphogenesis; and regulation of axon guidance. Located in axon and neuronal cell body. Expressed in several structures, including CAN; epithelial cell; ganglia; intestinal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome; dysostosis; and stomach cancer. Is an ortholog of human EFNB1 (ephrin B1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1934 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
      DOID:14737 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
  Molecular_info: Corresponding_CDS: F56A11.3
    Corresponding_transcript: F56A11.3.1
    Other_sequence: CR11929
      TS00903
      TSC03402_1
      CRC05251_1
      CBC06448_1
      CR02130
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00111800 Inferred_automatically: RNAi_primary
      WBRNAi00067312 Inferred_automatically: RNAi_primary
      WBRNAi00086136 Inferred_automatically: RNAi_primary
      WBRNAi00067361 Inferred_automatically: RNAi_primary
      WBRNAi00064650 Inferred_automatically: RNAi_primary
      WBRNAi00048574 Inferred_automatically: RNAi_primary
      WBRNAi00015760 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00000722
      WBCnstr00000723
      WBCnstr00006419
      WBCnstr00011024
      WBCnstr00037053
      WBCnstr00042431
      WBCnstr00042437
    Construct_product: WBCnstr00006419
      WBCnstr00021468
      WBCnstr00021469
      WBCnstr00021470
      WBCnstr00021472
      WBCnstr00021473
      WBCnstr00021477
      WBCnstr00022268
      WBCnstr00037053
    Antibody: WBAntibody00000596
    Microarray_results (21)
    Expression_cluster (158)
    Interaction: WBInteraction000000251
      WBInteraction000002082
      WBInteraction000002815
      WBInteraction000002816
      WBInteraction000002817
      WBInteraction000002819
      WBInteraction000004052
      WBInteraction000004053
      WBInteraction000004054
      WBInteraction000004055
      WBInteraction000004843
      WBInteraction000004844
      WBInteraction000005103
      WBInteraction000005440
      WBInteraction000005461
      WBInteraction000005464
      WBInteraction000006177
      WBInteraction000006766
      WBInteraction000006815
      WBInteraction000008780
      WBInteraction000008781
      WBInteraction000008782
      WBInteraction000008784
      WBInteraction000028617
      WBInteraction000029331
      WBInteraction000029695
      WBInteraction000029696
      WBInteraction000029748
      WBInteraction000030421
      WBInteraction000030422
      WBInteraction000030423
      WBInteraction000126392
      WBInteraction000136827
      WBInteraction000140842
      WBInteraction000140843
      WBInteraction000140844
      WBInteraction000140891
      WBInteraction000153201
      WBInteraction000165709
      WBInteraction000165721
      WBInteraction000166032
      WBInteraction000166248
      WBInteraction000166451
      WBInteraction000268413
      WBInteraction000322441
      WBInteraction000356890
      WBInteraction000366574
      WBInteraction000367858
      WBInteraction000369120
      WBInteraction000371302
      WBInteraction000392352
      WBInteraction000392531
      WBInteraction000417475
      WBInteraction000442425
      WBInteraction000446247
      WBInteraction000459007
      WBInteraction000541296
      WBInteraction000553813
      WBInteraction000556399
      WBInteraction000560778
      WBInteraction000560779
      WBInteraction000560780
      WBInteraction000560781
    WBProcess: WBbiopr:00000025
  Map_info: Map: IV Position: -25.7615 Error: 0.138637
    Positive: Positive_clone: F56A11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3132
        4992
        5641
  Reference (44)
  Method: Gene