WormBase Tree Display for Gene: WBGene00003056
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WBGene00003056 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lon | ||||||
Reference_allele | WBVar00143398 | ||||||
Allele (213) | |||||||
Legacy_information | e678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678). | ||||||
[C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974] | |||||||
Strain (224) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (19) | |||||||
Ortholog (25) | |||||||
Structured_description | Concise_description | lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface. | Paper_evidence | WBPaper00029002 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 24 Jan 2007 00:00:00 | ||||||
Automated_description | Enables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C39E6.1 | |||||
Corresponding_CDS_history | C39E6.1:wp107 | ||||||
Corresponding_transcript | C39E6.1.1 | ||||||
Other_sequence | CRC07010_1 | ||||||
CR09868 | |||||||
CGC00490_1 | |||||||
CBC13859_1 | |||||||
CJC03031_1 | |||||||
CRC04307_1 | |||||||
Associated_feature (15) | |||||||
Experimental_info | RNAi_result | WBRNAi00074006 | Inferred_automatically | RNAi_primary | |||
WBRNAi00024780 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00074001 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086335 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00029683 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00042209 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086338 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00074002 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086339 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086341 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00072376 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086329 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00074005 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086334 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084974 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00074003 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00112370 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00074000 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00074004 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00000364 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086340 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00008505 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086328 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr4651 | ||||||
Expr4652 | |||||||
Expr12191 | |||||||
Expr1011265 | |||||||
Expr1031435 | |||||||
Expr1146202 | |||||||
Expr2013244 | |||||||
Expr2031475 | |||||||
Drives_construct | WBCnstr00012150 | ||||||
WBCnstr00012151 | |||||||
WBCnstr00021097 | |||||||
WBCnstr00021479 | |||||||
WBCnstr00036259 | |||||||
Construct_product | WBCnstr00012151 | ||||||
WBCnstr00021471 | |||||||
WBCnstr00021474 | |||||||
WBCnstr00021479 | |||||||
WBCnstr00036259 | |||||||
Microarray_results (21) | |||||||
Expression_cluster (142) | |||||||
Interaction | WBInteraction000000646 | ||||||
WBInteraction000004036 | |||||||
WBInteraction000008816 | |||||||
WBInteraction000029530 | |||||||
WBInteraction000031116 | |||||||
WBInteraction000031117 | |||||||
WBInteraction000143172 | |||||||
WBInteraction000145327 | |||||||
WBInteraction000153250 | |||||||
WBInteraction000166030 | |||||||
WBInteraction000308117 | |||||||
WBInteraction000341846 | |||||||
WBInteraction000349992 | |||||||
WBInteraction000359026 | |||||||
WBInteraction000369316 | |||||||
WBInteraction000500734 | |||||||
WBInteraction000500735 | |||||||
WBInteraction000521785 | |||||||
WBInteraction000521941 | |||||||
WBInteraction000524031 | |||||||
WBInteraction000537302 | |||||||
WBInteraction000537303 | |||||||
WBInteraction000586815 | |||||||
WBInteraction000586816 | |||||||
Map_info | Map | X | Position | -6.74013 | Error | 0.007834 | |
Well_ordered | |||||||
Positive | Inside_rearr | mnDp30 | |||||
yDp4 | |||||||
Positive_clone | C39E6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
F43C9 | |||||||
Negative | Outside_rearr | mcDf2 | |||||
Mapping_data | 2_point (57) | ||||||
Multi_point (150) | |||||||
Pos_neg_data | 935 | ||||||
1859 | |||||||
1888 | |||||||
1912 | |||||||
1928 | |||||||
1944 | |||||||
1960 | |||||||
1976 | |||||||
1992 | |||||||
2019 | |||||||
2040 | |||||||
2051 | |||||||
2058 | |||||||
2174 | |||||||
2175 | |||||||
2178 | |||||||
2362 | |||||||
5453 | |||||||
5834 | |||||||
4564 | |||||||
8420 | |||||||
8422 | |||||||
8429 | |||||||
8433 | |||||||
8441 | |||||||
8446 | |||||||
8450 | |||||||
8456 | |||||||
8475 | |||||||
10694 | |||||||
10695 | |||||||
Landmark_gene | |||||||
Reference (155) | |||||||
Remark | sequence wsa incorrectly given as F43C9.3 | ||||||
Method | Gene |