WormBase Tree Display for Gene: WBGene00000226

WBGene00000226 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: T06E4
  Identity: Version: 1
    Name: CGC_name: atl-1 Person_evidence: WBPerson1551
      Sequence_name: T06E4.3
      Molecular_name: T06E4.3a
        T06E4.3a.1
        CE25103
        T06E4.3c
        CE45629
        T06E4.3a.2
        T06E4.3c.1
      Other_name: Ce-atl1 Accession_evidence: EMBL AB018598
        CELE_T06E4.3 Accession_evidence: NDB BX284605
      Public_name: atl-1
    DB_info: Database (15)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: atl
    Allele (123)
    Strain: WBStrain00036017
      WBStrain00006438
    RNASeq_FPKM (74)
    GO_annotation (25)
    Contained_in_operon: CEOP5585
    Ortholog (43)
    Paralog: WBGene00004879 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000227 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002583 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007028 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: The atl-1 gene encodes a large, 2514-residue protein of the ATM family, homologous to human AT (OMIM:208900, mutated in ataxia telangiectasia); the C-terminal sequence of ATL-1 contains a PI-3 kinase-like domain; ATL-1 is required for survival through early embryogenesis and normal chromosomal segregation; atl-1 is expressed in both the mitotic and meiotic cells of adult gonads. Paper_evidence: WBPaper00004326
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable 1-phosphatidylinositol-3-kinase activity and protein serine/threonine kinase activity. Involved in DNA damage checkpoint signaling; embryo development; and meiotic chromosome segregation. Located in nucleus. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Seckel syndrome 1; gastrointestinal system cancer (multiple); and pancreatic cancer. Is an ortholog of human ATR (ATR serine/threonine kinase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:882)
      DOID:9261 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:882)
      DOID:0070007 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:882)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:882)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:882)
      DOID:219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:882)
      DOID:0080202 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:882)
  Molecular_info: Corresponding_CDS (2)
    Corresponding_CDS_history: T06E4.3:wp52
      T06E4.3b:wp270
    Corresponding_transcript: T06E4.3a.1
      T06E4.3a.2
      T06E4.3c.1
    Other_sequence: AB018598
      SRC07073_1
      FC813984.1
      FG976670.1
    Associated_feature: WBsf652930
      WBsf669247
      WBsf234255
  Experimental_info: RNAi_result (23)
    Expr_pattern: Expr1119
      Expr1120
      Expr4273
      Expr11800
      Expr1019215
      Expr1030143
      Expr1156260
      Expr2009505
      Expr2027742
    Drives_construct: WBCnstr00037648
    Construct_product: WBCnstr00037648
    Antibody: WBAntibody00001035
      WBAntibody00001157
    Microarray_results (29)
    Expression_cluster (132)
    Interaction: WBInteraction000009935
      WBInteraction000029265
      WBInteraction000029560
      WBInteraction000029844
      WBInteraction000033017
      WBInteraction000033085
      WBInteraction000033335
      WBInteraction000033338
      WBInteraction000033354
      WBInteraction000033355
      WBInteraction000033419
      WBInteraction000033724
      WBInteraction000034214
      WBInteraction000034215
      WBInteraction000034216
      WBInteraction000034505
      WBInteraction000034915
      WBInteraction000034922
      WBInteraction000035071
      WBInteraction000035248
      WBInteraction000035291
      WBInteraction000035409
      WBInteraction000035419
      WBInteraction000035420
      WBInteraction000035421
      WBInteraction000035432
      WBInteraction000035592
      WBInteraction000037654
      WBInteraction000037655
      WBInteraction000038739
      WBInteraction000038862
      WBInteraction000039663
      WBInteraction000039737
      WBInteraction000040043
      WBInteraction000040336
      WBInteraction000040569
      WBInteraction000040570
      WBInteraction000041876
      WBInteraction000042968
      WBInteraction000043151
      WBInteraction000043340
      WBInteraction000043436
      WBInteraction000043815
      WBInteraction000045411
      WBInteraction000047055
      WBInteraction000047310
      WBInteraction000047558
      WBInteraction000047721
      WBInteraction000047722
      WBInteraction000047723
      WBInteraction000047932
      WBInteraction000048486
      WBInteraction000049413
      WBInteraction000049968
      WBInteraction000050402
      WBInteraction000050634
      WBInteraction000050635
      WBInteraction000050636
      WBInteraction000136796
      WBInteraction000145002
      WBInteraction000175495
      WBInteraction000180007
      WBInteraction000180134
      WBInteraction000181696
      WBInteraction000183916
      WBInteraction000194887
      WBInteraction000198659
      WBInteraction000201828
      WBInteraction000203614
      WBInteraction000217926
      WBInteraction000217947
      WBInteraction000218113
      WBInteraction000235544
      WBInteraction000238279
      WBInteraction000256265
      WBInteraction000272940
      WBInteraction000278746
      WBInteraction000279858
      WBInteraction000289773
      WBInteraction000291272
      WBInteraction000304955
      WBInteraction000318120
      WBInteraction000350715
      WBInteraction000358466
      WBInteraction000392174
      WBInteraction000394287
      WBInteraction000397014
      WBInteraction000408647
      WBInteraction000410286
      WBInteraction000432559
      WBInteraction000466202
      WBInteraction000501379
      WBInteraction000520427
      WBInteraction000520428
      WBInteraction000520429
      WBInteraction000520556
      WBInteraction000521605
      WBInteraction000521606
      WBInteraction000523990
      WBInteraction000525290
      WBInteraction000539813
      WBInteraction000539852
      WBInteraction000539853
      WBInteraction000539854
      WBInteraction000539861
      WBInteraction000539865
      WBInteraction000539881
      WBInteraction000539937
      WBInteraction000539938
      WBInteraction000539941
      WBInteraction000550979
      WBInteraction000550990
      WBInteraction000553031
      WBInteraction000581839
  Map_info: Map: V Position: 2.06022 Error: 0.000681
    Positive: Positive_clone: T06E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (70)
  Remark: Sequence connection from [Boulton S, Vidal M]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene