WormBase Tree Display for Gene: WBGene00001005

WBGene00001005 SMap: S_parent: Sequence: T26A5
  Identity: Version: 1
    Name: CGC_name: dlc-1 Person_evidence: WBPerson75
      Sequence_name: T26A5.9
      Molecular_name: T26A5.9
        T26A5.9.1
        CE00788
      Other_name: CELE_T26A5.9 Accession_evidence: NDB BX284603
      Public_name: dlc-1
    DB_info: Database: AceView gene 3H554
        WormQTL gene WBGene00001005
        WormFlux gene WBGene00001005
        NDB locus_tag CELE_T26A5.9
        Panther gene CAEEL|WormBase=WBGene00001005|UniProtKB=Q22799
          family PTHR11886
        NCBI gene 175922
        RefSeq protein NM_001392125.1
        SwissProt UniProtAcc Q22799
        TREEFAM TREEFAM_ID TF300264
        UniProt_GCRP UniProtAcc Q22799
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dlc
    Allele: WBVar01499890
      WBVar01499891
      WBVar01500260
      WBVar00251926
      WBVar00833776
      WBVar00833777
      WBVar00833778
      WBVar00833779
      WBVar00833780
      WBVar00399891
    Strain: WBStrain00001410
      WBStrain00002397
    RNASeq_FPKM (74)
    GO_annotation (25)
    Contained_in_operon: CEOP3840
    Ortholog (37)
    Paralog: WBGene00010888 Caenorhabditis elegans From_analysis: Panther
      WBGene00043067 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012424 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012425 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: dlc-1 encodes a dynein light chain 1, required for viability, that inhibits DHC-1 in vivo; DLC-1 is 92-95% identical to its orthologs human DYNLL1 (OMIM:601562) and DYNLL2 (OMIM:608942); DLC-1 is paralogous to DLC-2/-6; DLC-1 is expressed in adult body wall muscle, and in larval and adult pharynx, posterior intestine, and nervous system (e.g., ventral nerve cord, head neurons, and tail neurons); dlc-1 is probably transcriptionally activated by DAF-19; DLC-1 is required for normal embryonic and larval viability, embryonic pronuclear migration, growth speed, fertility, brood size, body shape, and cuticular integrity; anterograde movements of DLC-1 in neurons are regulated by PTL-1/Tau. Paper_evidence: WBPaper00004403
            WBPaper00005654
            WBPaper00006525
            WBPaper00025051
            WBPaper00029395
            WBPaper00030897
            WBPaper00038442
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson567
          Date_last_updated: 09 Aug 2011 00:00:00
      Automated_description: Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in several processes, including apoptotic process; cell division; and meiotic cell cycle. Predicted to be located in cytoplasm; microtubule; and nuclear envelope. Predicted to be part of cytoplasmic dynein complex. Expressed in several structures, including germ cell; germ line; rectal valve cell; somatic cell; and ventral nerve cord. Is an ortholog of human DYNLL2 (dynein light chain LC8-type 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T26A5.9
    Corresponding_transcript: T26A5.9.1
    Other_sequence: CRC04864_1
      EX550743.1
      ACC17829_1
      CR10632
    Associated_feature (11)
  Experimental_info: RNAi_result (62)
    Expr_pattern (17)
    Drives_construct: WBCnstr00002300
      WBCnstr00004298
      WBCnstr00018249
      WBCnstr00018250
      WBCnstr00019082
      WBCnstr00020991
      WBCnstr00037146
    Construct_product: WBCnstr00009770
      WBCnstr00009776
      WBCnstr00018249
      WBCnstr00018250
      WBCnstr00020274
      WBCnstr00020991
      WBCnstr00037146
      WBCnstr00039348
    Regulate_expr_cluster: WBPaper00055334:DLC-1_interacting
    Antibody: WBAntibody00001980
    Microarray_results (25)
    Expression_cluster (164)
    Interaction: WBInteraction000008249
      WBInteraction000008250
      WBInteraction000008251
      WBInteraction000009542
      WBInteraction000009887
      WBInteraction000009902
      WBInteraction000028297
      WBInteraction000028364
      WBInteraction000028365
      WBInteraction000028744
      WBInteraction000028877
      WBInteraction000028908
      WBInteraction000029003
      WBInteraction000029004
      WBInteraction000029382
      WBInteraction000029603
      WBInteraction000029694
      WBInteraction000030148
      WBInteraction000030172
      WBInteraction000030309
      WBInteraction000030310
      WBInteraction000030311
      WBInteraction000030312
      WBInteraction000030313
      WBInteraction000030314
      WBInteraction000030315
      WBInteraction000030316
      WBInteraction000030317
      WBInteraction000030318
      WBInteraction000030319
      WBInteraction000032811
      WBInteraction000032926
      WBInteraction000033729
      WBInteraction000034306
      WBInteraction000035891
      WBInteraction000036323
      WBInteraction000036463
      WBInteraction000036935
      WBInteraction000038545
      WBInteraction000039232
      WBInteraction000040108
      WBInteraction000040116
      WBInteraction000040213
      WBInteraction000040731
      WBInteraction000041601
      WBInteraction000041717
      WBInteraction000042954
      WBInteraction000045528
      WBInteraction000045944
      WBInteraction000046085
      WBInteraction000046091
      WBInteraction000046186
      WBInteraction000046913
      WBInteraction000047003
      WBInteraction000047251
      WBInteraction000047275
      WBInteraction000047535
      WBInteraction000048540
      WBInteraction000049134
      WBInteraction000049440
      WBInteraction000049563
      WBInteraction000049898
      WBInteraction000050060
      WBInteraction000050062
      WBInteraction000050488
      WBInteraction000051748
      WBInteraction000139174
      WBInteraction000146432
      WBInteraction000147038
      WBInteraction000150675
      WBInteraction000171718
      WBInteraction000173109
      WBInteraction000173392
      WBInteraction000173531
      WBInteraction000177011
      WBInteraction000177650
      WBInteraction000196320
      WBInteraction000207390
      WBInteraction000209820
      WBInteraction000214542
      WBInteraction000217876
      WBInteraction000217886
      WBInteraction000218238
      WBInteraction000219813
      WBInteraction000225688
      WBInteraction000236216
      WBInteraction000240730
      WBInteraction000255795
      WBInteraction000257005
      WBInteraction000260681
      WBInteraction000272506
      WBInteraction000286883
      WBInteraction000289132
      WBInteraction000293395
      WBInteraction000296425
      WBInteraction000302501
      WBInteraction000304832
      WBInteraction000316568
      WBInteraction000337489
      WBInteraction000343835
      WBInteraction000348582
      WBInteraction000355783
      WBInteraction000364785
      WBInteraction000374754
      WBInteraction000379771
      WBInteraction000384101
      WBInteraction000384247
      WBInteraction000384271
      WBInteraction000384452
      WBInteraction000384495
      WBInteraction000384527
      WBInteraction000384528
      WBInteraction000384557
      WBInteraction000384604
      WBInteraction000384625
      WBInteraction000384677
      WBInteraction000388225
      WBInteraction000388231
      WBInteraction000394186
      WBInteraction000399619
      WBInteraction000405236
      WBInteraction000413196
      WBInteraction000415341
      WBInteraction000423536
      WBInteraction000463241
      WBInteraction000466266
      WBInteraction000466267
      WBInteraction000469233
      WBInteraction000469353
      WBInteraction000470690
      WBInteraction000470784
      WBInteraction000470856
      WBInteraction000471389
      WBInteraction000473556
      WBInteraction000504034
      WBInteraction000506859
      WBInteraction000506860
      WBInteraction000506861
      WBInteraction000506862
      WBInteraction000506863
      WBInteraction000506864
      WBInteraction000506865
      WBInteraction000506866
      WBInteraction000506867
      WBInteraction000506868
      WBInteraction000506869
      WBInteraction000506870
      WBInteraction000506871
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      WBInteraction000506873
      WBInteraction000511192
      WBInteraction000511193
      WBInteraction000511194
      WBInteraction000511195
      WBInteraction000511196
      WBInteraction000511197
      WBInteraction000511199
      WBInteraction000511200
      WBInteraction000511209
      WBInteraction000511214
      WBInteraction000511215
      WBInteraction000511734
      WBInteraction000511736
      WBInteraction000511737
      WBInteraction000511738
      WBInteraction000511739
      WBInteraction000511740
      WBInteraction000512662
      WBInteraction000512702
      WBInteraction000512704
      WBInteraction000512705
      WBInteraction000512706
      WBInteraction000512707
      WBInteraction000512708
      WBInteraction000512709
      WBInteraction000512710
      WBInteraction000512711
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      WBInteraction000512713
      WBInteraction000512714
      WBInteraction000512715
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      WBInteraction000512717
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      WBInteraction000512720
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      WBInteraction000512722
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      WBInteraction000512725
      WBInteraction000512726
      WBInteraction000512727
      WBInteraction000512728
      WBInteraction000512729
      WBInteraction000512730
      WBInteraction000512731
      WBInteraction000512732
      WBInteraction000512733
      WBInteraction000512735
      WBInteraction000512736
      WBInteraction000512738
      WBInteraction000512739
      WBInteraction000512740
      WBInteraction000512741
      WBInteraction000512742
      WBInteraction000512743
      WBInteraction000515201
      WBInteraction000515203
      WBInteraction000515205
      WBInteraction000515206
      WBInteraction000515207
      WBInteraction000515209
      WBInteraction000516527
      WBInteraction000516528
      WBInteraction000516529
      WBInteraction000516534
      WBInteraction000516535
      WBInteraction000516536
      WBInteraction000520525
      WBInteraction000522875
      WBInteraction000522876
      WBInteraction000522877
      WBInteraction000522878
      WBInteraction000522879
      WBInteraction000522880
      WBInteraction000522881
      WBInteraction000522882
      WBInteraction000522883
      WBInteraction000522884
      WBInteraction000522959
      WBInteraction000523192
      WBInteraction000523279
      WBInteraction000523319
      WBInteraction000523561
      WBInteraction000525162
      WBInteraction000525163
      WBInteraction000525164
      WBInteraction000525165
      WBInteraction000525166
      WBInteraction000525167
      WBInteraction000525168
      WBInteraction000525169
      WBInteraction000538866
      WBInteraction000540066
      WBInteraction000540067
      WBInteraction000540070
      WBInteraction000540195
      WBInteraction000540836
      WBInteraction000541176
      WBInteraction000543126
      WBInteraction000543160
      WBInteraction000547233
      WBInteraction000548313
      WBInteraction000548580
      WBInteraction000548709
      WBInteraction000551451
      WBInteraction000553216
      WBInteraction000556590
      WBInteraction000558883
      WBInteraction000559844
      WBInteraction000560138
      WBInteraction000560236
      WBInteraction000560241
      WBInteraction000560362
      WBInteraction000560587
      WBInteraction000561114
      WBInteraction000561208
      WBInteraction000561453
      WBInteraction000562263
      WBInteraction000563773
      WBInteraction000565059
      WBInteraction000565060
      WBInteraction000565068
      WBInteraction000565069
      WBInteraction000569436
      WBInteraction000569774
      WBInteraction000570804
      WBInteraction000572020
      WBInteraction000573399
      WBInteraction000574511
      WBInteraction000577369
      WBInteraction000578969
      WBInteraction000578970
      WBInteraction000578971
      WBInteraction000578972
      WBInteraction000578973
      WBInteraction000578975
      WBInteraction000578976
      WBInteraction000579948
      WBInteraction000582930
      WBInteraction000583579
      WBInteraction000583580
      WBInteraction000583581
      WBInteraction000583582
      WBInteraction000583583
  Map_info: Map: III Position: -1.25437 Error: 0.00201
    Positive: Positive_clone: T26A5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (43)
  Remark: T25A5.9 is a misprint for T26A5.9. changing cosmid and sequence. [sdm 000921]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene