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WormBase Tree Display for Gene: WBGene00001431

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Name Class

WBGene00001431SMapS_parentSequenceF31D4
IdentityVersion1
NameCGC_namefkb-6Person_evidenceWBPerson466
Sequence_nameF31D4.3
Molecular_nameF31D4.3
F31D4.3.1
CE15929
Other_nameCELE_F31D4.3Accession_evidenceNDBBX284605
Public_namefkb-6
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfkb
Allele (29)
Legacy_information[Page AP] F31D4.3. No mutants known.
StrainWBStrain00001608
RNASeq_FPKM (74)
GO_annotation (11)
Ortholog (41)
ParalogWBGene00001426Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001427Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001433Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001428Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001429Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001430Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001432Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionfkb-6 encodes a peptidyl-prolyl cis-trans isomerase that is most closely related to mammalian FK506-binding protein 4; loss of fkb-6 activity via large-scale RNAi screens indicates that fkb-6 is required for embryonic and vulval development as well as wild type brood size; fkb-6 controls chromosome movement during meiotic prophase I, and thus pairing and synapsis; FKB-6 exhibits peptidyl-prolyl cis-trans isomerase activity in vitro, and physically interacts with the Hsp90 ortholog DAF-21; fkb-6 is expressed throughout the life cycle, but is seen predominantly in the adult dorsal, ventral nerve cords and germline with additional expression seen in the pharynx, hypodermis, body wall muscle cells and some somatic and gut cells.Paper_evidenceWBPaper00005599
WBPaper00024497
WBPaper00030836
WBPaper00051337
Curator_confirmedWBPerson1843
Date_last_updated12 Sep 2017 00:00:00
Automated_descriptionEnables Hsp90 protein binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be located in cytoplasm. Expressed in dorsal nerve cord; intestine; and ventral nerve cord. Human ortholog(s) of this gene implicated in major depressive disorder. Is an ortholog of human FKBP4 (FKBP prolyl isomerase 4) and FKBP5 (FKBP prolyl isomerase 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:1470Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3721)
Molecular_infoCorresponding_CDSF31D4.3
Corresponding_transcriptF31D4.3.1
Other_sequence (112)
Associated_featureWBsf655144
WBsf662281
Experimental_infoRNAi_resultWBRNAi00014141Inferred_automaticallyRNAi_primary
WBRNAi00111652Inferred_automaticallyRNAi_primary
WBRNAi00046001Inferred_automaticallyRNAi_primary
WBRNAi00106362Inferred_automaticallyRNAi_primary
WBRNAi00078330Inferred_automaticallyRNAi_primary
WBRNAi00076363Inferred_automaticallyRNAi_primary
WBRNAi00031614Inferred_automaticallyRNAi_primary
WBRNAi00066128Inferred_automaticallyRNAi_primary
WBRNAi00008087Inferred_automaticallyRNAi_primary
Expr_patternExpr4779
Expr5924
Expr16141
Expr1018568
Expr1030856
Expr1149900
Expr2011800
Expr2030038
Drives_constructWBCnstr00002447
WBCnstr00012239
WBCnstr00036954
Construct_productWBCnstr00036954
Microarray_results (21)
Expression_cluster (155)
InteractionWBInteraction000036310
WBInteraction000039177
WBInteraction000043248
WBInteraction000043249
WBInteraction000043250
WBInteraction000044363
WBInteraction000046185
WBInteraction000046452
WBInteraction000046716
WBInteraction000046717
WBInteraction000046757
WBInteraction000046990
WBInteraction000048144
WBInteraction000048530
WBInteraction000048564
WBInteraction000049786
WBInteraction000049787
WBInteraction000050372
WBInteraction000050680
WBInteraction000127252
WBInteraction000135303
WBInteraction000146185
WBInteraction000152305
WBInteraction000158040
WBInteraction000158041
WBInteraction000158042
WBInteraction000158934
WBInteraction000159601
WBInteraction000162849
WBInteraction000169129
WBInteraction000169396
WBInteraction000170011
WBInteraction000173162
WBInteraction000178770
WBInteraction000194081
WBInteraction000253606
WBInteraction000264850
WBInteraction000271142
WBInteraction000272835
WBInteraction000277371
WBInteraction000278114
WBInteraction000280898
WBInteraction000285307
WBInteraction000287427
WBInteraction000295403
WBInteraction000305496
WBInteraction000307710
WBInteraction000316019
WBInteraction000316373
WBInteraction000328544
WBInteraction000337342
WBInteraction000346681
WBInteraction000384962
WBInteraction000385242
WBInteraction000385997
WBInteraction000387207
WBInteraction000387627
WBInteraction000393167
WBInteraction000400300
WBInteraction000400497
WBInteraction000402021
WBInteraction000402034
WBInteraction000402597
WBInteraction000412245
WBInteraction000413126
WBInteraction000424054
WBInteraction000435492
WBInteraction000441464
WBInteraction000442602
WBInteraction000451506
WBInteraction000453042
WBInteraction000456828
WBInteraction000461594
WBInteraction000461860
WBInteraction000464540
WBInteraction000467550
WBInteraction000549080
WBInteraction000549387
WBInteraction000552134
WBInteraction000554155
WBInteraction000555773
WBInteraction000557871
WBInteraction000569534
WBInteraction000569537
WBInteraction000571634
WBInteraction000571646
WBInteraction000571658
WBInteraction000576993
WBInteraction000577564
WBInteraction000579490
WBInteraction000580000
Map_infoMapVPosition25.4031Error0.014716
PositivePositive_cloneF31D4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (13)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene