WormBase Tree Display for Gene: WBGene00001865

WBGene00001865 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: T04A11
  Identity: Version: 1
    Name: CGC_name: him-6 Person_evidence: WBPerson261
      Sequence_name: T04A11.6
      Molecular_name: T04A11.6
        T04A11.6.1
        CE31724
      Other_name: blm-1
        CELE_T04A11.6 Accession_evidence: NDB BX284604
      Public_name: him-6
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (11)
  Disease_info: Experimental_model: DOID:2717 Homo sapiens Paper_evidence: WBPaper00013454
          Accession_evidence: OMIM 210900
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2017 00:00:00
    Potential_model: DOID:2717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1058)
    Disease_relevance: Mutations in the human BLM gene (a RecQ family DNA helicase) are implicatd in Bloom syndrome, an inherited disorder characterized by short stature, increased sensitivity to sunlight, a greatly increased risk of cancer and infertility; at the cellular level it is characterized by genomic instability, in particular, hyperrecombination between sister chromatids and homologous chromosomes; the C. elegans BLM ortholog, him-6, exhibits DNA-dependent ATPase activity and mutants show an enhanced irradiation sensitivity, a partially defective S-phase checkpoint, and in reduced levels of DNA-damage induced apoptosis. Homo sapiens Paper_evidence: WBPaper00013454
          Accession_evidence: OMIM 604610
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2017 00:00:00
  Models_disease_asserted: WBDOannot00000132
    WBDOannot00000436
    WBDOannot00000437
    WBDOannot00000438
  Molecular_info: Corresponding_CDS: T04A11.6
    Corresponding_CDS_history: T04A11.6:wp84
    Corresponding_transcript: T04A11.6.1
    Other_sequence (32)
    Associated_feature: WBsf660814
      WBsf660815
      WBsf998136
      WBsf998137
      WBsf1018380
      WBsf1018381
      WBsf229300
  Experimental_info: RNAi_result: WBRNAi00008018 Inferred_automatically: RNAi_primary
      WBRNAi00075599 Inferred_automatically: RNAi_primary
      WBRNAi00052319 Inferred_automatically: RNAi_primary
      WBRNAi00018100 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1024637
      Expr1031098
      Expr1155954
      Expr2012431
      Expr2030667
    Drives_construct: WBCnstr00036640
    Construct_product: WBCnstr00036640
    Antibody: WBAntibody00002533
    Microarray_results (20)
    Expression_cluster (125)
    Interaction: WBInteraction000001958
      WBInteraction000002450
      WBInteraction000009163
      WBInteraction000009448
      WBInteraction000033002
      WBInteraction000033137
      WBInteraction000034081
      WBInteraction000034214
      WBInteraction000034887
      WBInteraction000034888
      WBInteraction000034889
      WBInteraction000034890
      WBInteraction000035048
      WBInteraction000035192
      WBInteraction000036629
      WBInteraction000036813
      WBInteraction000037599
      WBInteraction000038002
      WBInteraction000038093
      WBInteraction000038094
      WBInteraction000038846
      WBInteraction000038913
      WBInteraction000038972
      WBInteraction000040319
      WBInteraction000043348
      WBInteraction000043349
      WBInteraction000043367
      WBInteraction000043368
      WBInteraction000044542
      WBInteraction000044812
      WBInteraction000045645
      WBInteraction000046813
      WBInteraction000047336
      WBInteraction000047337
      WBInteraction000047696
      WBInteraction000047897
      WBInteraction000047900
      WBInteraction000049028
      WBInteraction000050503
      WBInteraction000052428
      WBInteraction000052747
      WBInteraction000052899
      WBInteraction000104390
      WBInteraction000105847
      WBInteraction000115813
      WBInteraction000116370
      WBInteraction000118748
      WBInteraction000121623
      WBInteraction000133013
      WBInteraction000139112
      WBInteraction000150133
      WBInteraction000150661
      WBInteraction000157067
      WBInteraction000157882
      WBInteraction000158196
      WBInteraction000158518
      WBInteraction000158658
      WBInteraction000159429
      WBInteraction000161726
      WBInteraction000161826
      WBInteraction000162336
      WBInteraction000167831
      WBInteraction000168310
      WBInteraction000173238
      WBInteraction000173800
      WBInteraction000185392
      WBInteraction000185729
      WBInteraction000206646
      WBInteraction000208568
      WBInteraction000210569
      WBInteraction000217926
      WBInteraction000217948
      WBInteraction000228447
      WBInteraction000270931
      WBInteraction000272635
      WBInteraction000296967
      WBInteraction000320851
      WBInteraction000324364
      WBInteraction000336690
      WBInteraction000336839
      WBInteraction000336840
      WBInteraction000337608
      WBInteraction000364303
      WBInteraction000368253
      WBInteraction000370480
      WBInteraction000372730
      WBInteraction000397943
      WBInteraction000402989
      WBInteraction000423668
      WBInteraction000425230
      WBInteraction000430490
      WBInteraction000430593
      WBInteraction000462255
      WBInteraction000466068
      WBInteraction000466377
      WBInteraction000467993
      WBInteraction000469041
      WBInteraction000470449
      WBInteraction000472001
      WBInteraction000472227
      WBInteraction000473443
      WBInteraction000475098
      WBInteraction000475296
      WBInteraction000504216
      WBInteraction000518388
      WBInteraction000538864
      WBInteraction000539852
      WBInteraction000539863
      WBInteraction000539865
      WBInteraction000539866
      WBInteraction000539867
      WBInteraction000539868
      WBInteraction000539938
      WBInteraction000539940
      WBInteraction000541879
      WBInteraction000541880
      WBInteraction000549959
      WBInteraction000550988
      WBInteraction000550989
      WBInteraction000550990
      WBInteraction000551009
      WBInteraction000556506
      WBInteraction000579380
  Map_info (4)
  Reference (74)
  Remark: Sequence connection from [Wicky C, Muller F]
  Method: Gene