WormBase Tree Display for Gene: WBGene00002048
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| WBGene00002048 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | B0244 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ida-1 | Person_evidence | WBPerson71 | |||||
| Sequence_name | B0244.2 | ||||||||
| Molecular_name | B0244.2 | ||||||||
| B0244.2.1 | |||||||||
| CE31867 | |||||||||
| Other_name | ia2 | Accession_evidence | EMBL | AF126740 | |||||
| CELE_B0244.2 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | ida-1 | ||||||||
| DB_info | Database | AceView | gene | 3G855 | |||||
| WormQTL | gene | WBGene00002048 | |||||||
| WormFlux | gene | WBGene00002048 | |||||||
| NDB | locus_tag | CELE_B0244.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002048|UniProtKB=G5EGJ5 | |||||||
| family | PTHR46106 | ||||||||
| NCBI | gene | 175807 | |||||||
| RefSeq | protein | NM_065844.7 | |||||||
| SwissProt | UniProtAcc | G5EGJ5 | |||||||
| TREEFAM | TREEFAM_ID | TF351976 | |||||||
| UniProt_GCRP | UniProtAcc | G5EGJ5 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ida | ||||||||
| Allele (167) | |||||||||
| Strain | WBStrain00003830 | ||||||||
| WBStrain00003831 | |||||||||
| WBStrain00003832 | |||||||||
| WBStrain00035598 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (39) | |||||||||
| Paralog (64) | |||||||||
| Structured_description | Concise_description | ida-1 encodes a protein tyrosine phosphatase-like receptor, orthologous to the mammalian type I diabetes autoantigens IA-2 and phogrin that are expressed in dense core vesicles of neuroendocrine tissue and involved in regulated protein secretion; in C. elegans, IDA-1 appears to be required for regulating presynaptic neurotransmission and in particular, for the neuropeptidergic control of egg-laying; ida-1 interacts genetically with unc-31 and unc-64, which encode proteins required for dense core vesicle fusion and exocytosis; ida-1 expression is detected in a subset of neurons in the anterior nerve ring, the ventral nerve cord, the tail, and the vulva, including the VC vulval motoneurons and the HSN egg-laying neurons; ida-1 is also detected in the vulval uv1 cells, non-neuronal cells that contain neurosecretory-like vesicles. | Paper_evidence | WBPaper00004433 | |||||
| WBPaper00004518 | |||||||||
| WBPaper00019367 | |||||||||
| WBPaper00019564 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Involved in positive regulation of anterior/posterior axon guidance; positive regulation of neurotransmitter secretion; and ventral cord development. Located in dense core granule and synapse. Expressed in several structures, including buccal cavity; neurons; preanal ganglion; somatic nervous system; and uv1. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Is an ortholog of human PTPRN2 (protein tyrosine phosphatase receptor type N2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00046108 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 Feb 2017 00:00:00 | ||||||||
| DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00046108 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Feb 2015 00:00:00 | ||||||||
| Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9676,HGNC:9677) | |||||
| DOID:11716 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9677) | ||||||
| Models_disease_in_annotation | WBDOannot00000345 | ||||||||
| WBDOannot00000388 | |||||||||
| Molecular_info | Corresponding_CDS | B0244.2 | |||||||
| Corresponding_CDS_history | B0244.2:wp86 | ||||||||
| B0244.2b:wp18 | |||||||||
| Corresponding_transcript | B0244.2.1 | ||||||||
| Other_sequence (97) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00000950 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00038791 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038790 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028026 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009628 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005822 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009627 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (14) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00000646 | ||||||||
| WBCnstr00005801 | |||||||||
| WBCnstr00006969 | |||||||||
| WBCnstr00008654 | |||||||||
| WBCnstr00018579 | |||||||||
| WBCnstr00036495 | |||||||||
| Antibody | WBAntibody00000901 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (299) | |||||||||
| Interaction | WBInteraction000002377 | ||||||||
| WBInteraction000002378 | |||||||||
| WBInteraction000002379 | |||||||||
| WBInteraction000002380 | |||||||||
| WBInteraction000029411 | |||||||||
| WBInteraction000029738 | |||||||||
| WBInteraction000030224 | |||||||||
| WBInteraction000030885 | |||||||||
| WBInteraction000052946 | |||||||||
| WBInteraction000120929 | |||||||||
| WBInteraction000124414 | |||||||||
| WBInteraction000136047 | |||||||||
| WBInteraction000141933 | |||||||||
| WBInteraction000162214 | |||||||||
| WBInteraction000165165 | |||||||||
| WBInteraction000165878 | |||||||||
| WBInteraction000165879 | |||||||||
| WBInteraction000165880 | |||||||||
| WBInteraction000168215 | |||||||||
| WBInteraction000181987 | |||||||||
| WBInteraction000190803 | |||||||||
| WBInteraction000196079 | |||||||||
| WBInteraction000213357 | |||||||||
| WBInteraction000213484 | |||||||||
| WBInteraction000227962 | |||||||||
| WBInteraction000229511 | |||||||||
| WBInteraction000252529 | |||||||||
| WBInteraction000260803 | |||||||||
| WBInteraction000311023 | |||||||||
| WBInteraction000314085 | |||||||||
| WBInteraction000320543 | |||||||||
| WBInteraction000323414 | |||||||||
| WBInteraction000329748 | |||||||||
| WBInteraction000345326 | |||||||||
| WBInteraction000356903 | |||||||||
| WBInteraction000363293 | |||||||||
| WBInteraction000370469 | |||||||||
| WBInteraction000375248 | |||||||||
| WBInteraction000376037 | |||||||||
| WBInteraction000380430 | |||||||||
| WBInteraction000389206 | |||||||||
| WBInteraction000396611 | |||||||||
| WBInteraction000401859 | |||||||||
| WBInteraction000421703 | |||||||||
| WBInteraction000430905 | |||||||||
| WBInteraction000432663 | |||||||||
| WBInteraction000446249 | |||||||||
| WBInteraction000503806 | |||||||||
| WBInteraction000503955 | |||||||||
| WBInteraction000503956 | |||||||||
| WBInteraction000503957 | |||||||||
| WBInteraction000504044 | |||||||||
| WBInteraction000504864 | |||||||||
| WBInteraction000504865 | |||||||||
| WBInteraction000505009 | |||||||||
| WBInteraction000520714 | |||||||||
| WBInteraction000520717 | |||||||||
| WBInteraction000536108 | |||||||||
| WBInteraction000536115 | |||||||||
| WBInteraction000556181 | |||||||||
| WBInteraction000569799 | |||||||||
| WBInteraction000569802 | |||||||||
| WBInteraction000580088 | |||||||||
| Map_info | Map | III | Position | -1.44641 | Error | 6.5e-05 | |||
| Positive | Positive_clone | B0244 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4431 | |||||||
| Pseudo_map_position | |||||||||
| Reference (32) | |||||||||
| Remark | Sequence connection from [Zahn TA, Macmorris MA] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
