Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00002239

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00002239SMapS_parentSequenceF13B9
IdentityVersion1
NameCGC_nameksr-1Person_evidenceWBPerson237
Sequence_nameF13B9.5
Molecular_nameF13B9.5
F13B9.5.1
CE25854
Other_namesur-3
sar-2
CELE_F13B9.5Accession_evidenceNDBBX284606
Public_nameksr-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classksr
Allele (175)
Legacy_information[Kornfeld K] ksr for kinase suppressor of ras. ksr-1 loss-of-function mutations suppress the multivulva phenotype caused by let-60(n1046gf), cause a very low penetrance defect in vulval lineages, and cause about 10% larval lethality with a characteristic rod-like morphology.
[C.elegansII] pka sur-3, sar-2. Mutations suppress ras mutation,let-60(n1046gf). No phenotype alone in VPC; some larval lethality, Egl and Mig phenotypes. [MT; MH]
StrainWBStrain00026498
WBStrain00026503
WBStrain00027335
WBStrain00027336
WBStrain00027337
WBStrain00031627
RNASeq_FPKM (74)
GO_annotation (25)
Ortholog (40)
Paralog (11)
Structured_descriptionConcise_descriptionksr-1 encodes one of two C. elegans Kinase Suppressor of Ras paralogs; during development, ksr-1 functions singly to control sex myoblast migration and redundantly with ksr-2 to control development of the vulva, excretory system, and male spicules; as ksr-2; ksr-1 doubly mutant animals have severely reduced or absent MPK-1/ERK diphosphorylation levels in somatic tissue, KSR-2 and KSR-1 likely function to positively regulate signaling through the LET-60/Ras pathway; genetic analyses have identified a number of ekl (enhancer of ksr-1 lethality ) mutations that, in combination with a ksr-1 null mutation, result in defects in excretory duct cell fate specification accompanied by larval lethality; the ekl mutations identified gene products that are maternally required for duct cell fate specification and encode proteins likely to be involved in transcriptional and post-transcriptional gene regulation.Paper_evidenceWBPaper00002350
WBPaper00002351
WBPaper00005155
WBPaper00031487
Curator_confirmedWBPerson1843
Date_last_updated12 May 2009 00:00:00
Automated_descriptionEnables mitogen-activated protein kinase kinase binding activity and protein kinase activity. Involved in several processes, including defense response to Gram-positive bacterium; myoblast migration; and positive regulation of vulval development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Is an ortholog of human KSR1 (kinase suppressor of ras 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3458Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6465)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6465)
Molecular_infoCorresponding_CDSF13B9.5
Corresponding_transcriptF13B9.5.1
Other_sequence (19)
Associated_feature (7)
Experimental_infoRNAi_result (11)
Expr_patternExpr1011978
Expr1031314
Expr1148436
Expr2012981
Expr2031213
Drives_constructWBCnstr00036367
Construct_productWBCnstr00036367
Microarray_results (25)
Expression_cluster (96)
InteractionWBInteraction000000430
WBInteraction000000667
WBInteraction000000739
WBInteraction000000740
WBInteraction000000741
WBInteraction000001359
WBInteraction000001607
WBInteraction000002022
WBInteraction000002327
WBInteraction000002354
WBInteraction000002700
WBInteraction000002705
WBInteraction000004651
WBInteraction000004985
WBInteraction000004986
WBInteraction000005029
WBInteraction000006012
WBInteraction000006097
WBInteraction000006098
WBInteraction000006099
WBInteraction000006100
WBInteraction000006101
WBInteraction000006102
WBInteraction000006129
WBInteraction000007087
WBInteraction000007490
WBInteraction000007497
WBInteraction000009390
WBInteraction000009391
WBInteraction000009952
WBInteraction000030979
WBInteraction000030980
WBInteraction000030981
WBInteraction000035112
WBInteraction000035113
WBInteraction000035353
WBInteraction000036594
WBInteraction000036595
WBInteraction000052728
WBInteraction000121241
WBInteraction000126465
WBInteraction000126498
WBInteraction000126500
WBInteraction000132994
WBInteraction000133645
WBInteraction000147255
WBInteraction000147256
WBInteraction000165918
WBInteraction000166267
WBInteraction000180424
WBInteraction000180429
WBInteraction000200027
WBInteraction000209201
WBInteraction000220034
WBInteraction000232818
WBInteraction000241170
WBInteraction000254691
WBInteraction000259414
WBInteraction000279211
WBInteraction000282620
WBInteraction000287688
WBInteraction000290254
WBInteraction000295793
WBInteraction000295896
WBInteraction000307319
WBInteraction000314958
WBInteraction000331845
WBInteraction000333045
WBInteraction000337280
WBInteraction000344574
WBInteraction000352750
WBInteraction000356557
WBInteraction000366279
WBInteraction000367012
WBInteraction000370181
WBInteraction000375642
WBInteraction000381642
WBInteraction000386237
WBInteraction000387306
WBInteraction000388608
WBInteraction000389576
WBInteraction000396374
WBInteraction000399435
WBInteraction000413138
WBInteraction000413915
WBInteraction000417316
WBInteraction000417373
WBInteraction000417659
WBInteraction000428547
WBInteraction000431183
WBInteraction000457595
WBInteraction000459335
WBInteraction000459807
WBInteraction000519144
WBInteraction000522509
WBInteraction000524421
WBInteraction000535560
WBInteraction000540007
WBInteraction000549843
WBProcessWBbiopr:00000071
Map_info (4)
Reference (102)
MethodGene