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WormBase Tree Display for Gene: WBGene00003247

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Name Class

WBGene00003247SMapS_parentSequenceZC504
IdentityVersion3
NameCGC_namemig-15Person_evidenceWBPerson261
Sequence_nameZC504.4
Molecular_name (12)
Other_nameqid-7Person_evidenceWBPerson1157
qid-8Person_evidenceWBPerson1157
CELE_ZC504.4Accession_evidenceNDBBX284606
Public_namemig-15
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:31WBPerson1971EventImportedInitial conversion from geneace
204 Nov 2014 12:25:34WBPerson2970EventAcquires_mergeWBGene00004262
Name_changeOther_nameqid-7
304 Nov 2014 12:27:29WBPerson2970EventAcquires_mergeWBGene00004263
Name_changeOther_nameqid-8
Acquires_mergeWBGene00004263
WBGene00004262
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmig
Allele (101)
Legacy_information[Hedgecock EM] QL migration resembles QR. Pleiotropic defects in hypodermis.
[C.elegansII] rh148 : QL migration resembles QR. Pleiotropic defects in hypodermis. [CF]
StrainWBStrain00024147
WBStrain00024148
WBStrain00028841
WBStrain00028845
WBStrain00028859
WBStrain00004868
WBStrain00004869
RNASeq_FPKM (74)
GO_annotation (29)
Ortholog (41)
Paralog (27)
Structured_descriptionConcise_descriptionmig-15 encodes the C. elegans ortholog of vertebrate Nck-interacting kinase (NIK) which belongs to the STE20/germinal center kinase (GCK) family; MIG-15 is required for normal axon pathfinding, and to inhibit premature branching of commissures; RNAi of mig-15 and pat-3, which encodes a beta1A integrins, results in similar axonal defects, and mutations in ina-1, which encodes an alpha integrin chain, enhances the commissural phenotype of mig-15 mutations; MIG-15 also regulates multiple aspects Q cell behavior, including initial Q cell polarization (direction of lamellipodium extension) and maintenance of that polarity, as well as migration of the Q cells and their descendants; genetic mosaic analyses indicate that MIG-15 likely acts cell autonomously at least in AQR and PQR to regulate their migration; MIG-15 physically interacts with the cytoplasmic domain of the beta1A integrin, PAT-3; loss of mig-15 results in increased synapse number and synaptic tiling defect in DA neurons.Paper_evidenceWBPaper00005218
WBPaper00032247
WBPaper00026842
WBPaper00006110
WBPaper00054962
Person_evidenceWBPerson3718
Curator_confirmedWBPerson1843
WBPerson324
WBPerson567
Date_last_updated10 Oct 2018 00:00:00
Automated_descriptionPredicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1826Homo sapiensPaper_evidenceWBPaper00035198
Curator_confirmedWBPerson38202
Date_last_updated04 Jun 2018 00:00:00
Potential_modelDOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6866)
DOID:3910Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6866)
DOID:0081216Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:30765)
DOID:10534Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6866)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6866)
DOID:2043Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6866)
Models_disease_assertedWBDOannot00000550
WBDOannot00000551
WBDOannot00000555
Molecular_infoCorresponding_CDSZC504.4a
ZC504.4b
ZC504.4c
ZC504.4d
Corresponding_transcript (4)
Other_sequence (61)
Associated_feature (18)
Experimental_infoRNAi_result (21)
Expr_patternExpr1844
Expr8961
Expr1027934
Expr1031541
Expr1162414
Expr2013563
Expr2031796
Drives_constructWBCnstr00010481
WBCnstr00013639
WBCnstr00036163
Construct_productWBCnstr00010481
WBCnstr00022525
WBCnstr00036163
Microarray_results (43)
Expression_cluster (104)
InteractionWBInteraction000001658
WBInteraction000004617
WBInteraction000005168
WBInteraction000005409
WBInteraction000009754
WBInteraction000009936
WBInteraction000028402
WBInteraction000028410
WBInteraction000028962
WBInteraction000029783
WBInteraction000029784
WBInteraction000030551
WBInteraction000031252
WBInteraction000031253
WBInteraction000031254
WBInteraction000031255
WBInteraction000031256
WBInteraction000031257
WBInteraction000032552
WBInteraction000032553
WBInteraction000032564
WBInteraction000032696
WBInteraction000032758
WBInteraction000032997
WBInteraction000033388
WBInteraction000033508
WBInteraction000033611
WBInteraction000033760
WBInteraction000033862
WBInteraction000033865
WBInteraction000033866
WBInteraction000034071
WBInteraction000034674
WBInteraction000036332
WBInteraction000049310
WBInteraction000049691
WBInteraction000050575
WBInteraction000052893
WBInteraction000122727
WBInteraction000126897
WBInteraction000138566
WBInteraction000143135
WBInteraction000146645
WBInteraction000150044
WBInteraction000150793
WBInteraction000160385
WBInteraction000164233
WBInteraction000167380
WBInteraction000167780
WBInteraction000238743
WBInteraction000246897
WBInteraction000251297
WBInteraction000259701
WBInteraction000263041
WBInteraction000263163
WBInteraction000272562
WBInteraction000327450
WBInteraction000347193
WBInteraction000349226
WBInteraction000361465
WBInteraction000362730
WBInteraction000370666
WBInteraction000372021
WBInteraction000372109
WBInteraction000384276
WBInteraction000393600
WBInteraction000405498
WBInteraction000410838
WBInteraction000438349
WBInteraction000451730
WBInteraction000455420
WBInteraction000458933
WBInteraction000513927
WBInteraction000513929
WBInteraction000513931
WBInteraction000513933
WBInteraction000513934
WBInteraction000513935
WBInteraction000513936
WBInteraction000513937
WBInteraction000513938
WBInteraction000513940
WBInteraction000513942
WBInteraction000513943
WBInteraction000513944
WBInteraction000513947
WBInteraction000513948
WBInteraction000515983
WBInteraction000516400
WBInteraction000516401
WBInteraction000516402
WBInteraction000516403
WBInteraction000516404
WBInteraction000516405
WBInteraction000516406
WBInteraction000516407
WBInteraction000516408
WBInteraction000516448
WBInteraction000540199
WBInteraction000543305
WBInteraction000545959
WBInteraction000546219
WBInteraction000549860
WBInteraction000549868
WBInteraction000549874
WBInteraction000553222
WBInteraction000558202
WBInteraction000558203
WBInteraction000576321
WBInteraction000582273
WBInteraction000584399
Anatomy_functionWBbtf0783
WBbtf0784
WBProcessWBbiopr:00000082
WBbiopr:00000107
WBbiopr:00000111
Map_infoMapXPosition2.19018Error0.003698
Well_ordered
PositivePositive_cloneZC504Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point3293
3294
3295
3296
4886
4133
Reference (46)
MethodGene