WormBase Tree Display for Gene: WBGene00003371

WBGene00003371 SMap: S_parent: Sequence: F09F7
  Identity: Version: 1
    Name: CGC_name: mlc-3 Person_evidence: WBPerson21
      Sequence_name: F09F7.2
      Molecular_name: F09F7.2a
        F09F7.2a.1
        CE01236
        F09F7.2b
        CE30652
        F09F7.2a.2
        F09F7.2b.1
      Other_name: CELE_F09F7.2 Accession_evidence: NDB BX284603
      Public_name: mlc-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mlc
    Allele (34)
    Legacy_information: [C.elegansII] NMK. Encodes alkali (essential) MLC; >40% identity to vertebrate and invertebrate MLC.Transcripts 1.05 kb, 0.75 kb. [TR]
    Strain: WBStrain00002370
      WBStrain00002883
    RNASeq_FPKM (74)
    GO_annotation: 00021121
      00021122
      00047966
      00110796
    Ortholog (51)
    Paralog: WBGene00011734 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010554 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009585 Caenorhabditis elegans From_analysis: Panther
      WBGene00023451 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: mlc-3 encodes an essential myosin light chain; large-scale RNAi screens indicate that mlc-3 activity is required for both embryonic and postembryonic development, as well as for normal locomotion and egg laying. Paper_evidence: WBPaper00001230
            WBPaper00003624
            WBPaper00004403
            WBPaper00005654
            WBPaper00006395
            WBPaper00024497
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Oct 2006 00:00:00
      Automated_description: Predicted to enable calcium ion binding activity. Located in striated muscle myosin thick filament. Expressed in head neurons; nervous system; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Is an ortholog of human MYL3 (myosin light chain 3) and MYL6B (myosin light chain 6B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110314 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7584)
  Molecular_info: Corresponding_CDS: F09F7.2a
      F09F7.2b
    Corresponding_transcript: F09F7.2a.1
      F09F7.2a.2
      F09F7.2b.1
    Other_sequence (250)
    Associated_feature (11)
  Experimental_info: RNAi_result (13)
    Expr_pattern: Chronogram945
      Expr5703
      Expr9360
      Expr1018734
      Expr1031550
      Expr1148121
      Expr2013591
      Expr2031824
    Drives_construct: WBCnstr00003020
      WBCnstr00004502
      WBCnstr00036154
    Construct_product: WBCnstr00013925
      WBCnstr00036154
    Microarray_results (32)
    Expression_cluster (258)
    Interaction: WBInteraction000007126
      WBInteraction000007448
      WBInteraction000038496
      WBInteraction000041223
      WBInteraction000041224
      WBInteraction000041992
      WBInteraction000041993
      WBInteraction000041994
      WBInteraction000041995
      WBInteraction000041996
      WBInteraction000042955
      WBInteraction000049337
      WBInteraction000231638
      WBInteraction000280801
      WBInteraction000346645
      WBInteraction000351479
      WBInteraction000379309
      WBInteraction000393287
      WBInteraction000539597
      WBInteraction000539601
      WBInteraction000539602
      WBInteraction000539606
      WBInteraction000539612
      WBInteraction000539624
      WBInteraction000539641
      WBInteraction000542700
      WBInteraction000542794
      WBInteraction000547716
      WBInteraction000550074
      WBInteraction000551440
      WBInteraction000553966
      WBInteraction000554409
      WBInteraction000561733
      WBInteraction000562078
      WBInteraction000562362
      WBInteraction000562532
      WBInteraction000564055
      WBInteraction000566296
      WBInteraction000566575
      WBInteraction000568236
      WBInteraction000569261
      WBInteraction000572087
      WBInteraction000572489
      WBInteraction000572752
      WBInteraction000578715
      WBInteraction000580162
      WBInteraction000583048
      WBInteraction000584339
  Map_info: Map: III Position: -1.54187 Error: 0.002181
    Positive: Positive_clone: F09F7 Inferred_automatically: From sequence, transcript, pseudogene data
        MLC4C
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene