WormBase Tree Display for Gene: WBGene00004264

WBGene00004264 Evidence: Person_evidence: WBPerson83
  SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: qua-1 Person_evidence: WBPerson83
      Sequence_name: T05C12.10
      Molecular_name: T05C12.10
        T05C12.10.1
        CE34989
      Other_name: CELE_T05C12.10 Accession_evidence: NDB BX284602
      Public_name: qua-1
    DB_info: Database: AceView gene 2I493
        WormQTL gene WBGene00004264
        WormFlux gene WBGene00004264
        NDB locus_tag CELE_T05C12.10
        Panther gene CAEEL|WormBase=WBGene00004264|UniProtKB=G5EC21
          family PTHR46706
        NCBI gene 174319
        RefSeq protein NM_063324.5
        SwissProt UniProtAcc G5EC21
        TREEFAM TREEFAM_ID TF106458
        UniProt_GCRP UniProtAcc G5EC21
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: qua
    Allele (70)
    Strain: WBStrain00002356
      WBStrain00035500
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (31)
    Paralog (24)
    Structured_description: Concise_description: qua-1 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Qua domain, a 5W repeat, an extended region oflow-complexity sequence, and a Hint/Hog domain; QUA-1 is conserved amongnematodes from Caenorhabditis to Brugia; QUA-1 is expressed prior tomolting in hyp1 to hyp11 hypodermal cells, but not in seam cells, andceases to be expressed after each molting cycle or in gravid adults nolonger molting; QUA-1 is strongly required for normal molting, withlethal molting defects in qua-1 mutants and severe defects inqua-1(RNAi) animals; similar molting defects in RNAi of ptr-4 and ptr-23(encoding Dispatched homologs) suggest that PTR-4 and PTR-23 may exportQUA-1 from hypodermal cells synthesizing it; other sites of QUA-1expression include intestinal and rectal cells, excretory duct and porecells, sensilla support cells, the P cell lineage in L1, body wallmuscle, and the adult reproductive system; QUA-1 is also required fornormal adult alae formation, growth to full size, cuticle adhesion,locomotion, and male tail development; the Hint/Hog domain is predictedto cut QUA-1 into two halves and then covalently link cholesterol to theC-terminus of the Qua domain; the Qua domain is predicted to form acysteine-crosslinked protein involved in intercellular signalling, andthe Qua domain has subtle similarity to the N-terminal Hedge domain ofHEDGEHOG proteins; both Qua and Hint/Hog domains are required fortransgenic rescue of a lethal qua-1 allele; defects in both qua-1mutants and qua-1(RNAi) animals; all of QUA-1's functions may reflectcommon defects in cholesterol-dependent hedgehog-like signalling. Paper_evidence: WBPaper00003717
            WBPaper00006525
            WBPaper00026763
            WBPaper00026841
            WBPaper00027129
            WBPaper00027263
          Curator_confirmed: WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Involved in molting cycle and nematode larval development. Acts upstream of or within nematode male tail mating organ morphogenesis. Located in collagen and cuticulin-based cuticle extracellular matrix. Expressed in several structures, including P1; P12; P2; excretory system; and hypodermal cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T05C12.10
    Corresponding_CDS_history: T05C12.10:wp106
    Corresponding_transcript: T05C12.10.1
    Other_sequence (40)
    Associated_feature: WBsf657206
      WBsf657945
      WBsf988670
      WBsf988671
      WBsf1012657
      WBsf1012658
      WBsf221705
      WBsf221706
  Experimental_info: RNAi_result (33)
    Expr_pattern (11)
    Drives_construct: WBCnstr00002958
      WBCnstr00004471
      WBCnstr00006893
      WBCnstr00011601
      WBCnstr00011933
      WBCnstr00015885
      WBCnstr00035603
    Construct_product: WBCnstr00015885
      WBCnstr00035603
    Microarray_results (19)
    Expression_cluster (324)
    Interaction: WBInteraction000005764
      WBInteraction000006087
      WBInteraction000006372
      WBInteraction000107321
      WBInteraction000109029
      WBInteraction000110503
      WBInteraction000113411
      WBInteraction000114324
      WBInteraction000114846
      WBInteraction000115721
      WBInteraction000118169
      WBInteraction000118406
      WBInteraction000118493
      WBInteraction000119300
      WBInteraction000120138
      WBInteraction000120322
      WBInteraction000120640
      WBInteraction000121032
      WBInteraction000122481
      WBInteraction000124210
      WBInteraction000124449
      WBInteraction000124710
      WBInteraction000124845
      WBInteraction000124915
      WBInteraction000125280
      WBInteraction000125921
      WBInteraction000134614
      WBInteraction000134752
      WBInteraction000137282
      WBInteraction000137867
      WBInteraction000137882
      WBInteraction000138664
      WBInteraction000139046
      WBInteraction000141422
      WBInteraction000142610
      WBInteraction000143510
      WBInteraction000143575
      WBInteraction000144153
      WBInteraction000146080
      WBInteraction000146682
      WBInteraction000147304
      WBInteraction000147661
      WBInteraction000147939
      WBInteraction000148241
      WBInteraction000149358
      WBInteraction000149779
      WBInteraction000150070
      WBInteraction000150084
      WBInteraction000150330
      WBInteraction000151433
      WBInteraction000156517
      WBInteraction000156875
      WBInteraction000160771
      WBInteraction000161198
      WBInteraction000165077
      WBInteraction000174772
      WBInteraction000176278
      WBInteraction000176958
      WBInteraction000177085
      WBInteraction000178019
      WBInteraction000178511
      WBInteraction000178874
      WBInteraction000180926
      WBInteraction000181060
      WBInteraction000182206
      WBInteraction000183175
      WBInteraction000183258
      WBInteraction000185125
      WBInteraction000186944
      WBInteraction000189609
      WBInteraction000194362
      WBInteraction000195088
      WBInteraction000195979
      WBInteraction000197673
      WBInteraction000199416
      WBInteraction000199498
      WBInteraction000200799
      WBInteraction000202197
      WBInteraction000204485
      WBInteraction000204903
      WBInteraction000207933
      WBInteraction000209759
      WBInteraction000210675
      WBInteraction000211128
      WBInteraction000211204
      WBInteraction000211987
      WBInteraction000212067
      WBInteraction000213222
      WBInteraction000214178
      WBInteraction000217786
      WBInteraction000217836
      WBInteraction000218587
      WBInteraction000220852
      WBInteraction000221232
      WBInteraction000221571
      WBInteraction000222212
      WBInteraction000224560
      WBInteraction000224879
      WBInteraction000225109
      WBInteraction000226945
      WBInteraction000228670
      WBInteraction000231277
      WBInteraction000232840
      WBInteraction000234283
      WBInteraction000237050
      WBInteraction000237074
      WBInteraction000237852
      WBInteraction000238566
      WBInteraction000238623
      WBInteraction000239347
      WBInteraction000239669
      WBInteraction000241343
      WBInteraction000242355
      WBInteraction000244940
      WBInteraction000245016
      WBInteraction000245356
      WBInteraction000248970
      WBInteraction000253352
      WBInteraction000255451
      WBInteraction000257964
      WBInteraction000260001
      WBInteraction000261363
      WBInteraction000261904
      WBInteraction000266809
      WBInteraction000267941
      WBInteraction000268076
      WBInteraction000269833
      WBInteraction000271159
      WBInteraction000272710
      WBInteraction000275401
      WBInteraction000281875
      WBInteraction000283375
      WBInteraction000284095
      WBInteraction000290991
      WBInteraction000291247
      WBInteraction000292434
      WBInteraction000301659
      WBInteraction000309352
      WBInteraction000312455
      WBInteraction000313891
      WBInteraction000314726
      WBInteraction000320546
      WBInteraction000322477
      WBInteraction000322982
      WBInteraction000326334
      WBInteraction000329769
      WBInteraction000330199
      WBInteraction000330933
      WBInteraction000334851
      WBInteraction000338218
      WBInteraction000345970
      WBInteraction000356453
      WBInteraction000360133
      WBInteraction000364983
      WBInteraction000370099
      WBInteraction000374980
      WBInteraction000379015
      WBInteraction000393426
      WBInteraction000395832
      WBInteraction000396561
      WBInteraction000401031
      WBInteraction000404561
      WBInteraction000407984
      WBInteraction000423946
      WBInteraction000449545
      WBInteraction000452561
      WBInteraction000459115
      WBInteraction000503366
      WBInteraction000560965
    WBProcess: WBbiopr:00000123
  Map_info: Map: II Position: 0.749646 Error: 0.000106
    Positive: Positive_clone: T05C12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4617
    Pseudo_map_position
  Reference (18)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene