WormBase Tree Display for Gene: WBGene00006435

WBGene00006435 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F25G6
  Identity: Version: 2
    Name: CGC_name: stdh-4
      Sequence_name: F25G6.5
      Molecular_name: F25G6.5a
        F25G6.5a.1
        CE47137
        F25G6.5b
        CE52769
        F25G6.5b.1
      Other_name: tag-57 Person_evidence: WBPerson201
        CELE_F25G6.5 Accession_evidence: NDB BX284605
      Public_name: stdh-4
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 27 Nov 2007 15:17:26 WBPerson2970 Name_change: CGC_name: stdh-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: stdh
    Allele (28)
    Strain: WBStrain00002288
      WBStrain00035663
    RNASeq_FPKM (74)
    GO_annotation: 00003241
      00003242
      00003243
      00003244
      00028932
      00028933
    Ortholog (67)
    Paralog (38)
    Structured_description: Concise_description: stdh-4 encodes a putative steroid dehydrogenase expressed in larval and adult pharynx; STDH-4 is orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1, and paralogous to LET-767 and STDH-1/-3; STDH-4 has no obvious function in mass RNAi assays. Paper_evidence: WBPaper00006204
            WBPaper00006525
            WBPaper00031006
          Curator_confirmed: WBPerson567
          Date_last_updated: 26 Nov 2007 00:00:00
      Automated_description: Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and Alzheimer's disease. Is an ortholog of human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5212)
      DOID:1923 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5212)
      DOID:0112248 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5212)
  Molecular_info: Corresponding_CDS: F25G6.5a
      F25G6.5b
    Corresponding_CDS_history: F25G6.5:wp230
    Corresponding_transcript: F25G6.5a.1
      F25G6.5b.1
    Other_sequence (11)
    Associated_feature: WBsf718354
      WBsf1000690
      WBsf1000691
      WBsf1000692
      WBsf1020052
  Experimental_info: RNAi_result: WBRNAi00045527 Inferred_automatically: RNAi_primary
      WBRNAi00013885 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1449
      Chronogram1662
      Expr5858
      Expr1012380
      Expr1149442
      Expr2016959
      Expr2035107
    Drives_construct: WBCnstr00002988
      WBCnstr00004487
      WBCnstr00037909
    Construct_product: WBCnstr00037909
    Microarray_results (18)
    Expression_cluster (40)
    Interaction: WBInteraction000041464
      WBInteraction000111830
      WBInteraction000114178
      WBInteraction000114411
      WBInteraction000114439
      WBInteraction000114828
      WBInteraction000115215
      WBInteraction000115780
      WBInteraction000115787
      WBInteraction000115927
      WBInteraction000117458
      WBInteraction000117642
      WBInteraction000117791
      WBInteraction000118250
      WBInteraction000118485
      WBInteraction000118585
      WBInteraction000118833
      WBInteraction000118834
      WBInteraction000118835
      WBInteraction000118882
      WBInteraction000118969
      WBInteraction000118997
      WBInteraction000119007
      WBInteraction000119146
      WBInteraction000119185
      WBInteraction000119212
      WBInteraction000119396
      WBInteraction000119411
      WBInteraction000119420
      WBInteraction000119649
      WBInteraction000119650
      WBInteraction000119706
      WBInteraction000119721
      WBInteraction000119722
      WBInteraction000119791
      WBInteraction000119801
      WBInteraction000120294
      WBInteraction000120519
      WBInteraction000120529
      WBInteraction000120887
      WBInteraction000124189
      WBInteraction000125085
      WBInteraction000125781
      WBInteraction000127025
      WBInteraction000133495
      WBInteraction000134275
      WBInteraction000163341
      WBInteraction000180178
      WBInteraction000181133
      WBInteraction000200541
      WBInteraction000211849
      WBInteraction000218667
      WBInteraction000232376
      WBInteraction000254146
      WBInteraction000254479
      WBInteraction000271787
      WBInteraction000280824
      WBInteraction000286507
      WBInteraction000295095
      WBInteraction000299355
      WBInteraction000299777
      WBInteraction000305589
      WBInteraction000306470
      WBInteraction000308506
      WBInteraction000311502
      WBInteraction000317547
      WBInteraction000323242
      WBInteraction000330579
      WBInteraction000336435
      WBInteraction000338725
      WBInteraction000343250
      WBInteraction000355826
      WBInteraction000372397
      WBInteraction000381102
      WBInteraction000381601
      WBInteraction000387094
      WBInteraction000416378
      WBInteraction000418774
      WBInteraction000426441
      WBInteraction000428632
      WBInteraction000436197
      WBInteraction000436274
      WBInteraction000449270
      WBInteraction000455201
      WBInteraction000461048
      WBInteraction000462046
      WBInteraction000463899
      WBInteraction000464036
      WBInteraction000464037
      WBInteraction000466224
  Map_info: Map: V Position: 1.4451 Error: 0.002002
    Positive: Positive_clone: F25G6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4869
    Pseudo_map_position
  Reference: WBPaper00018598
    WBPaper00038491
    WBPaper00042257
    WBPaper00055090
  Remark: Gene name created from parsing 'genotype' field from CGC strain information CGC_data_submission
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene