WormBase Tree Display for Gene: WBGene00008419
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| WBGene00008419 | SMap | S_parent | Sequence | D2030 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | wdr-23 | Person_evidence | WBPerson590 | |||||
| Sequence_name | D2030.9 | ||||||||
| Molecular_name (16) | |||||||||
| Other_name | xrep-1 | Paper_evidence | WBPaper00036411 | ||||||
| Person_evidence | WBPerson1284 | ||||||||
| CELE_D2030.9 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | wdr-23 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 26 Mar 2007 13:57:19 | WBPerson2970 | Name_change | CGC_name | wdr-23 | ||||
| 3 | 01 Oct 2010 14:04:48 | WBPerson2970 | Name_change | Other_name | xrep-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | wdr | ||||||||
| Allele (92) | |||||||||
| Strain | WBStrain00001583 | ||||||||
| WBStrain00001735 | |||||||||
| WBStrain00005859 | |||||||||
| WBStrain00005861 | |||||||||
| WBStrain00055405 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Contained_in_operon | CEOP1408 | ||||||||
| Ortholog (33) | |||||||||
| Structured_description | Concise_description | wdr-23 encodes a WD40 repeat-containing protein; WDR-23 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that negatively regulates accumulation and hence, transcriptional activation activity of the SKN-1 transcription factor in intestinal nuclei; wdr-23 activity is thus required for regulation of stress resistance, longevity, and normal growth and development; WDR-23 physically interacts with DDB-1 and SKN-1, thus likely serving as a bridge between the ubiquitin ligase complex and its SKN-1 substrate; in regulating skn-1 function, wdr-23 appears to act downstream of the p38 MAPK pathway and together with gsk-3 and the daf-2-mediated insulin signaling pathway; WDR-23 is expressed in the intestine, hypodermis, and neurons, where it localizes to nuclei. | Paper_evidence | WBPaper00032980 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 06 Apr 2010 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in several cellular components, including intracellular membrane-bounded organelle; neuronal cell body; and striated muscle dense body. Expressed in ASIL; ASIR; head; muscle cell; and tail. Is an ortholog of human DCAF11 (DDB1 and CUL4 associated factor 11). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | D2030.9a | |||||||
| D2030.9b | |||||||||
| D2030.9c | |||||||||
| D2030.9d | |||||||||
| D2030.9e | |||||||||
| Corresponding_transcript | D2030.9a.1 | ||||||||
| D2030.9a.2 | |||||||||
| D2030.9b.1 | |||||||||
| D2030.9c.1 | |||||||||
| D2030.9d.1 | |||||||||
| D2030.9e.1 | |||||||||
| Other_sequence (26) | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result (54) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product (14) | |||||||||
| Regulate_expr_cluster | WBPaper00042215:wdr-23(tm1817)_downregulated | ||||||||
| WBPaper00042215:wdr-23(tm1817)_upregulated | |||||||||
| WBPaper00044743:wdr-23_neuron_upregulated | |||||||||
| WBPaper00059566:wdr-23(mac32)_downregulated | |||||||||
| WBPaper00059566:wdr-23(mac32)_upregulated | |||||||||
| Microarray_results (40) | |||||||||
| Expression_cluster (155) | |||||||||
| Interaction | WBInteraction000051412 | ||||||||
| WBInteraction000254632 | |||||||||
| WBInteraction000318673 | |||||||||
| WBInteraction000375775 | |||||||||
| WBInteraction000382657 | |||||||||
| WBInteraction000409246 | |||||||||
| WBInteraction000424730 | |||||||||
| WBInteraction000433000 | |||||||||
| WBInteraction000437962 | |||||||||
| WBInteraction000503935 | |||||||||
| WBInteraction000503936 | |||||||||
| WBInteraction000504477 | |||||||||
| WBInteraction000518061 | |||||||||
| WBInteraction000518101 | |||||||||
| WBInteraction000518129 | |||||||||
| WBInteraction000518173 | |||||||||
| WBInteraction000518207 | |||||||||
| WBInteraction000518258 | |||||||||
| WBInteraction000518293 | |||||||||
| WBInteraction000520023 | |||||||||
| WBInteraction000520024 | |||||||||
| WBInteraction000520025 | |||||||||
| WBInteraction000520026 | |||||||||
| WBInteraction000520027 | |||||||||
| WBInteraction000520028 | |||||||||
| WBInteraction000520317 | |||||||||
| WBInteraction000520318 | |||||||||
| WBInteraction000521021 | |||||||||
| WBInteraction000521022 | |||||||||
| WBInteraction000521619 | |||||||||
| WBInteraction000521621 | |||||||||
| WBInteraction000524193 | |||||||||
| WBInteraction000524194 | |||||||||
| WBInteraction000525382 | |||||||||
| WBInteraction000538803 | |||||||||
| WBInteraction000540824 | |||||||||
| WBInteraction000540843 | |||||||||
| WBInteraction000542532 | |||||||||
| WBInteraction000555487 | |||||||||
| WBInteraction000563416 | |||||||||
| WBInteraction000563417 | |||||||||
| WBInteraction000563418 | |||||||||
| Map_info | Map | I | Position | 2.19591 | Error | 0.005029 | |||
| Positive | Positive_clone | D2030 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (48) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
