WormBase Tree Display for Gene: WBGene00015658
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| WBGene00015658 | SMap | S_parent | Sequence | C09G12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | tsg-101 | Person_evidence | WBPerson3188 | |||||
| WBPerson1816 | |||||||||
| Sequence_name | C09G12.9 | ||||||||
| Molecular_name | C09G12.9 | ||||||||
| C09G12.9.1 | |||||||||
| CE34675 | |||||||||
| Other_name | CELE_C09G12.9 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | tsg-101 | ||||||||
| DB_info | Database | AceView | gene | 4E276 | |||||
| WormQTL | gene | WBGene00015658 | |||||||
| WormFlux | gene | WBGene00015658 | |||||||
| NDB | locus_tag | CELE_C09G12.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00015658|UniProtKB=O76258 | |||||||
| family | PTHR23306 | ||||||||
| NCBI | gene | 182474 | |||||||
| RefSeq | protein | NM_067963.6 | |||||||
| TREEFAM | TREEFAM_ID | TF312917 | |||||||
| TrEMBL | UniProtAcc | O76258 | |||||||
| UniProt_GCRP | UniProtAcc | O76258 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 30 Oct 2007 14:27:24 | WBPerson2970 | Name_change | CGC_name | tsg-101 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tsg | ||||||||
| Allele (77) | |||||||||
| Strain | WBStrain00002625 | ||||||||
| WBStrain00002534 | |||||||||
| WBStrain00051306 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Contained_in_operon | CEOP4088 | ||||||||
| Ortholog (46) | |||||||||
| Structured_description | Concise_description | tsg-101 encodes the C. elegans ortholog of S. cerevisiae vacuolar protein sorting protein Vps23p and human TUMOR SUSCEPTIBILITY GENE 101 (TSG101; OMIM:601387), mutations in which are associated with several types of cancer and with varying responses to HIV infection; TSG-101 is an essential component of the C. elegans ESCRT-1 (Endosomal Sorting Complex Required for Transport, other members include VPS-28, VPS-37, and MVB-12) that is required for cell surface receptor degradation via the multivesicular body sorting pathway and hence, downregulation of receptor activity. | Paper_evidence | WBPaper00026641 | |||||
| WBPaper00031035 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Jul 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable ubiquitin binding activity. Involved in endosome to lysosome transport via multivesicular body sorting pathway and receptor catabolic process. Located in endosome membrane. Part of ESCRT I complex. Expressed in head and tail. Human ortholog(s) of this gene implicated in breast carcinoma and reproductive organ cancer (multiple). Is an ortholog of human TSG101 (tumor susceptibility 101). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||
| DOID:2893 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
| DOID:2870 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
| DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
| Molecular_info | Corresponding_CDS | C09G12.9 | |||||||
| Corresponding_CDS_history | C09G12.9:wp105 | ||||||||
| Corresponding_transcript | C09G12.9.1 | ||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf667837 | ||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Chronogram751 | ||||||||
| Chronogram1424 | |||||||||
| Expr5223 | |||||||||
| Expr5224 | |||||||||
| Expr1020827 | |||||||||
| Expr1036705 | |||||||||
| Expr1144298 | |||||||||
| Expr2017537 | |||||||||
| Expr2035675 | |||||||||
| Drives_construct | WBCnstr00003110 | ||||||||
| WBCnstr00004547 | |||||||||
| WBCnstr00028680 | |||||||||
| Construct_product | WBCnstr00028680 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (76) | |||||||||
| Interaction | WBInteraction000037194 | ||||||||
| WBInteraction000037278 | |||||||||
| WBInteraction000049319 | |||||||||
| WBInteraction000115165 | |||||||||
| WBInteraction000149374 | |||||||||
| WBInteraction000164255 | |||||||||
| WBInteraction000164479 | |||||||||
| WBInteraction000167792 | |||||||||
| WBInteraction000174356 | |||||||||
| WBInteraction000174357 | |||||||||
| WBInteraction000177105 | |||||||||
| WBInteraction000185359 | |||||||||
| WBInteraction000185513 | |||||||||
| WBInteraction000186654 | |||||||||
| WBInteraction000186679 | |||||||||
| WBInteraction000186773 | |||||||||
| WBInteraction000202797 | |||||||||
| WBInteraction000216951 | |||||||||
| WBInteraction000233156 | |||||||||
| WBInteraction000273036 | |||||||||
| WBInteraction000323925 | |||||||||
| WBInteraction000339849 | |||||||||
| WBInteraction000339850 | |||||||||
| WBInteraction000364588 | |||||||||
| WBInteraction000504601 | |||||||||
| WBInteraction000519212 | |||||||||
| WBInteraction000522623 | |||||||||
| WBInteraction000522626 | |||||||||
| WBInteraction000522627 | |||||||||
| WBInteraction000523147 | |||||||||
| WBInteraction000523148 | |||||||||
| WBInteraction000523149 | |||||||||
| WBInteraction000523150 | |||||||||
| WBInteraction000523151 | |||||||||
| WBInteraction000523152 | |||||||||
| WBInteraction000523153 | |||||||||
| WBInteraction000523267 | |||||||||
| WBInteraction000523795 | |||||||||
| WBInteraction000547224 | |||||||||
| WBInteraction000547225 | |||||||||
| WBInteraction000559065 | |||||||||
| WBInteraction000566067 | |||||||||
| WBInteraction000580919 | |||||||||
| WBInteraction000584481 | |||||||||
| WBInteraction000584952 | |||||||||
| Map_info | Map | IV | Position | -3.31212 | Error | 0.00351 | |||
| Positive | Positive_clone | C09G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
