WormBase Tree Display for Gene: WBGene00004457
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WBGene00004457 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C01B7 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | rpm-1 | Person_evidence | WBPerson451 | |||||
Sequence_name | C01B7.6 | ||||||||
Molecular_name | C01B7.6 | ||||||||
C01B7.6.1 | |||||||||
CE06730 | |||||||||
Other_name | rpm-3 | ||||||||
sam-1 | |||||||||
sad-3 | |||||||||
syd-3 | |||||||||
CELE_C01B7.6 | Accession_evidence | NDB | BX284605 | ||||||
Public_name | rpm-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | rpm | ||||||||
Allele (126) | |||||||||
Strain | WBStrain00005412 | ||||||||
WBStrain00001745 | |||||||||
WBStrain00029055 | |||||||||
WBStrain00029056 | |||||||||
WBStrain00031377 | |||||||||
WBStrain00005362 | |||||||||
WBStrain00037463 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (74) | |||||||||
Ortholog (45) | |||||||||
Paralog | WBGene00017190 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | rpm-1 encodes an E3 ubiquitin ligase that contains an N-terminal RCC1 (regulator of chromosome condensation)-like guanine nucleotide exchange factor (GEF) domain and that is orthologous to Drosophila highwire and murine Phr1; RPM-1 functions autonomously within several different types of neurons to regulate presynaptic differentiation; in regulating axon termination, RPM-1 acts through the GLO-4 guanine nucleotide exchange factor that positively regulates vesicular trafficking through GLO-1/Rab; in regulating synaptogenesis, RPM-1 functions as part of an SCF-like ubiquitin ligase complex that negatively regulates signaling through the DLK-1 MAP kinase cascade; RPM-1 is expressed in most, if not all, neurons from the comma stage of embryogenesis through adulthood; RPM-1 expression is also seen in the pharynx, coelomocytes, and distal tip cells; in neurons, RPM-1 localizes to presynaptic terminals. | Paper_evidence | WBPaper00004146 | |||||
WBPaper00004147 | |||||||||
WBPaper00024212 | |||||||||
WBPaper00024955 | |||||||||
WBPaper00030940 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 26 Nov 2007 00:00:00 | ||||||||
Automated_description | Enables mitogen-activated protein kinase kinase kinase binding activity; protein phosphatase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intracellular signal transduction; regulation of neuron projection development; and regulation of synapse assembly. Located in axon; neuromuscular junction; and presynaptic periactive zone. Expressed in several structures, including coelomocyte; hermaphrodite distal tip cell; nerve ring; pharynx; and touch receptor neurons. Is an ortholog of human MYCBP2 (MYC binding protein 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C01B7.6 | |||||||
Corresponding_transcript | C01B7.6.1 | ||||||||
Other_sequence (42) | |||||||||
Associated_feature | WBsf669186 | ||||||||
WBsf669187 | |||||||||
WBsf669188 | |||||||||
WBsf669189 | |||||||||
WBsf234135 | |||||||||
WBsf234136 | |||||||||
WBsf234137 | |||||||||
Experimental_info | RNAi_result (11) | ||||||||
Expr_pattern (15) | |||||||||
Drives_construct | WBCnstr00000713 | ||||||||
WBCnstr00002560 | |||||||||
WBCnstr00006401 | |||||||||
WBCnstr00010055 | |||||||||
WBCnstr00021120 | |||||||||
WBCnstr00035471 | |||||||||
Construct_product | WBCnstr00000717 | ||||||||
WBCnstr00006401 | |||||||||
WBCnstr00019627 | |||||||||
WBCnstr00021081 | |||||||||
WBCnstr00021082 | |||||||||
WBCnstr00021120 | |||||||||
WBCnstr00021121 | |||||||||
WBCnstr00035471 | |||||||||
WBCnstr00040000 | |||||||||
WBCnstr00041440 | |||||||||
Antibody | WBAntibody00000282 | ||||||||
WBAntibody00001369 | |||||||||
Microarray_results | SMD_C01B7.6 | ||||||||
173636_at | |||||||||
175875_s_at | |||||||||
181455_s_at | |||||||||
A_12_P109817 | |||||||||
Aff_C01B7.6 | |||||||||
GPL13394_WBGene00004457 | |||||||||
GPL13914_C01B7.6 | |||||||||
GPL14144_C01B7.6_10719-10778_0.902_28_C | |||||||||
GPL14144_C01B7.6_10855-10914_0.936_4_B | |||||||||
GPL14144_C01B7.6_10907-10966_0.938_3_A | |||||||||
GPL14144_F07B7.12_5477-5536_0.955_2_B | |||||||||
GPL14144_F07B7.12_5526-5585_0.956_1_A | |||||||||
GPL14144_F07B7.12_5620-5679_0.946_4_C | |||||||||
GPL19516_CGZ0001653 | |||||||||
GPL19516_CGZ0014638 | |||||||||
GPL21109_C01B7.6 | |||||||||
GPL21109_F07B7.12 | |||||||||
GPL3518_CE06730 | |||||||||
GPL8304_CE_WBGene00004457_A | |||||||||
GPL8304_CE_WBGene00004457_C | |||||||||
GPL8673_C01B7_6P10016 | |||||||||
GPL8673_C01B7_6P10872 | |||||||||
GPL8673_C01B7_6P11096 | |||||||||
GPL8673_F07B7_12P04328 | |||||||||
GPL8673_F07B7_12P04908 | |||||||||
GPL8673_F07B7_12P05597 | |||||||||
GPL9450_C01B7.6 | |||||||||
cea2.d.18986 | |||||||||
cea2.p.107511 | |||||||||
Expression_cluster (154) | |||||||||
Interaction (111) | |||||||||
WBProcess | WBbiopr:00000117 | ||||||||
Map_info | Map | V | Position | 1.62029 | Error | 0.012923 | |||
Positive | Positive_clone | C01B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4092 | |||||||
4093 | |||||||||
Pos_neg_data | 10723 | ||||||||
10724 | |||||||||
10725 | |||||||||
10726 | |||||||||
10727 | |||||||||
Reference (123) | |||||||||
Remark | Sequence connection from [Jin Y, Nonet M] | ||||||||
old_name sam-1 becomes new_name rpm-1 from [Jin Y, Nonet M]. | |||||||||
[email 93 from R. Lee and cgc4523] | |||||||||
Sequence connection from [Zhen M] | |||||||||
Method | Gene |