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WormBase Tree Display for Gene: WBGene00000406

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Name Class

WBGene00000406SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namecdk-4Person_evidenceWBPerson346
Sequence_nameF18H3.5
Molecular_nameF18H3.5
F18H3.5.1
CE18608
Other_nameCELE_F18H3.5Accession_evidenceNDBBX284606
Public_namecdk-4
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcdk
Allele (67)
Legacy_information[Krause MW] cdk-4 is a cyclin dependent kinase related to cdk-4 and cdk-6 from other organims. Homozygous cdk-4(gv3) animals usually arrest in L2 due to no, or limited, proliferation of the post-embryonic blast cells. About 3% of animals make it to a late stage of development.
StrainWBStrain00023588
WBStrain00034600
WBStrain00034601
WBStrain00003937
RNASeq_FPKM (74)
GO_annotation (36)
OrthologWBGene00065262Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00029488Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00150886Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00147171Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00135737Caenorhabditis japonicaFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00223705Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g11916Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g15625Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g7876Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g12696Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP28.g18216Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g5222Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP29.g573Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g19197Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g11819Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g476Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g11227Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g26083Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g27142Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g4609Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g3947Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cni-cdk-4Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g22074Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00475.g11851Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_01608Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_025724Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g01844Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g2179Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_X0150900Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrX_pilon.g20427Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00239637Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00096549Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00291427Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0016131Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-131121-149Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-060929-974Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-060503-786Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
PhylomeDB
SonicParanoid
HGNC:1773Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
PhylomeDB
HGNC:1777Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
PhylomeDB
MGI:88357Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
OrthoInspector
PhylomeDB
MGI:1277162Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
OrthoInspector
PhylomeDB
RGD:621120Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
PhylomeDB
RGD:621121Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
PhylomeDB
Paralog (17)
Structured_descriptionConcise_descriptioncdk-4 encodes two isoforms of a cyclin-dependent serine/threonine protein kinase orthologous to human CDK4 and CDK6 (OMIM:123829 and OMIM:603368, mutated in cutanous malignant melanoma) which complex with D-type cyclins to regulate progression through the G1 phase of the cell cycle; CDK-4 activity is essential for G1 progression in postembryonic blast cells and as a result, cdk-4 mutant animals generally arrest during larval stages; the lethality generated by cdk mutations, also seen in animals doubly mutant for cdk-4 and cyd-1, a C. elegans D-type cyclin, can be suppressed by mutations in lin-35/Rb suggesting that, as in other organisms, LIN-35/Rb may be a major target of CDK-4/CYD-1 kinase activity; CDK-4 expression is first detected in neuronal and hypodermal lineages during mid-to-late embryogenesis, with postembryonic expression detected in hypodermal seam cells, cells of the P lineage which will give rise to ventral cord neurons, and cells of the somatic gonad, the vulva, and the intestine.Paper_evidenceWBPaper00003752
WBPaper00004192
WBPaper00005298
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables protein serine/threonine kinase activity. Involved in nematode larval development; positive regulation of cell cycle process; and reproductive process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Expressed in gonad; intestine; neurons; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); central nervous system cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human CDK4 (cyclin dependent kinase 4) and CDK6 (cyclin dependent kinase 6).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:162Homo sapiensPaper_evidenceWBPaper00046296
Curator_confirmedWBPerson324
Date_last_updated04 Feb 2015 00:00:00
Potential_model (24)
Models_disease_in_annotationWBDOannot00000346
Molecular_infoCorresponding_CDSF18H3.5
Corresponding_CDS_historyF18H3.5b:wp61
F18H3.5b:wp271
Corresponding_transcriptF18H3.5.1
Other_sequence (22)
Associated_featureWBsf654531
WBsf671198
WBsf1007631
WBsf1024243
WBsf238141
Experimental_infoRNAi_result (13)
Expr_patternExpr1156
Expr1017984
Expr1030223
Expr1148945
Expr2009811
Expr2028052
Drives_constructWBCnstr00010112
WBCnstr00016185
WBCnstr00020118
WBCnstr00020130
WBCnstr00021180
WBCnstr00037565
Construct_productWBCnstr00010112
WBCnstr00016185
WBCnstr00020118
WBCnstr00020130
WBCnstr00037565
Regulate_expr_clusterWBPaper00040426:CYD-1_CDK-4_downregulated
WBPaper00040426:CYD-1_CDK-4_upregulated
Microarray_results (24)
Expression_cluster (137)
Interaction (61)
Map_infoMapXPosition12.6771Error0.006799
PositivePositive_cloneF18H3Person_evidenceWBPerson346
Inferred_automaticallyFrom sequence, transcript, pseudogene data
H06A10Person_evidenceWBPerson346
Mapping_dataMulti_point4138
4196
Pseudo_map_position
Reference (36)
RemarkThe deletion allele was isolated in a PCR-based screen following the method of Barstead and Moulder. The deletion break points have been identified by sequence. We have rescued the cdk-4(gv3) mutant using a wild type copy of the cdk-4 cDNA expressed under the control of cdk-4 ~3 kb of 5' flanking sequences.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene