WormBase Tree Display for Gene: WBGene00003247

WBGene00003247 SMap: S_parent: Sequence: ZC504
  Identity: Version: 3
    Name: CGC_name: mig-15 Person_evidence: WBPerson261
      Sequence_name: ZC504.4
      Molecular_name (12)
      Other_name (3)
      Public_name: mig-15
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 04 Nov 2014 12:25:34 WBPerson2970 Event: Acquires_merge: WBGene00004262
              Name_change: Other_name: qid-7
        3 04 Nov 2014 12:27:29 WBPerson2970 Event: Acquires_merge: WBGene00004263
              Name_change: Other_name: qid-8
      Acquires_merge: WBGene00004263
        WBGene00004262
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mig
    Allele (101)
    Legacy_information: [Hedgecock EM] QL migration resembles QR. Pleiotropic defects in hypodermis.
      [C.elegansII] rh148 : QL migration resembles QR. Pleiotropic defects in hypodermis. [CF]
    Strain: WBStrain00024147
      WBStrain00024148
      WBStrain00028841
      WBStrain00028845
      WBStrain00028859
      WBStrain00004868
      WBStrain00004869
    RNASeq_FPKM (74)
    GO_annotation (29)
    Ortholog: WBGene00058466 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00036935 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00142400 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00227661 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g3003 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g10560 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g3150 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g11934 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g16018 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g25173 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g4024 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g6026 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP40.g20289 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00065.g3191 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-mig-15 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g13745 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00005.g322 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01327 Caenorhabditis latens From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01487 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2292 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0071700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g19902 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00214227 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00239868 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00089664 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00259107 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285506 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0010909 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-3767 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-091113-25 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060526-45 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-6722 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:6866 Homo sapiens From_analysis: OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:30765 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:17565 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1349394 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1355329 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1916264 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1561817 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1305322 Rattus norvegicus From_analysis: OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1359135 Rattus norvegicus From_analysis: OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog (27)
    Structured_description: Concise_description: mig-15 encodes the C. elegans ortholog of vertebrate Nck-interacting kinase (NIK) which belongs to the STE20/germinal center kinase (GCK) family; MIG-15 is required for normal axon pathfinding, and to inhibit premature branching of commissures; RNAi of mig-15 and pat-3, which encodes a beta1A integrins, results in similar axonal defects, and mutations in ina-1, which encodes an alpha integrin chain, enhances the commissural phenotype of mig-15 mutations; MIG-15 also regulates multiple aspects Q cell behavior, including initial Q cell polarization (direction of lamellipodium extension) and maintenance of that polarity, as well as migration of the Q cells and their descendants; genetic mosaic analyses indicate that MIG-15 likely acts cell autonomously at least in AQR and PQR to regulate their migration; MIG-15 physically interacts with the cytoplasmic domain of the beta1A integrin, PAT-3; loss of mig-15 results in increased synapse number and synaptic tiling defect in DA neurons. Paper_evidence: WBPaper00005218
            WBPaper00032247
            WBPaper00026842
            WBPaper00006110
            WBPaper00054962
          Person_evidence: WBPerson3718
          Curator_confirmed: WBPerson1843
            WBPerson324
            WBPerson567
          Date_last_updated: 10 Oct 2018 00:00:00
      Automated_description: Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1826 Homo sapiens Paper_evidence: WBPaper00035198
          Curator_confirmed: WBPerson38202
          Date_last_updated: 04 Jun 2018 00:00:00
    Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6866)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6866)
      DOID:0081216 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:30765)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6866)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6866)
      DOID:2043 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6866)
  Models_disease_asserted: WBDOannot00000550
    WBDOannot00000551
    WBDOannot00000555
  Molecular_info: Corresponding_CDS: ZC504.4a
      ZC504.4b
      ZC504.4c
      ZC504.4d
    Corresponding_transcript: ZC504.4a.1
      ZC504.4b.1
      ZC504.4c.1
      ZC504.4d.1
    Other_sequence (61)
    Associated_feature (18)
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr1844
      Expr8961
      Expr1027934
      Expr1031541
      Expr1162414
      Expr2013563
      Expr2031796
    Drives_construct: WBCnstr00010481
      WBCnstr00013639
      WBCnstr00036163
    Construct_product: WBCnstr00010481
      WBCnstr00022525
      WBCnstr00036163
    Microarray_results (43)
    Expression_cluster (104)
    Interaction (111)
    Anatomy_function: WBbtf0783
      WBbtf0784
    WBProcess: WBbiopr:00000082
      WBbiopr:00000107
      WBbiopr:00000111
  Map_info: Map: X Position: 2.19018 Error: 0.003698
    Well_ordered
    Positive: Positive_clone: ZC504 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3293
        3294
        3295
        3296
        4886
        4133
  Reference (46)
  Method: Gene