WormBase Tree Display for Gene: WBGene00004046

WBGene00004046 SMap: S_parent: Sequence: F45E4
  Identity: Version: 1
    Name: CGC_name: plp-1 Person_evidence: WBPerson539
      Sequence_name: F45E4.2
      Molecular_name: F45E4.2
        F45E4.2.1
        CE10494
      Other_name: CELE_F45E4.2 Accession_evidence: NDB BX284604
      Public_name: plp-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: plp
    Allele (21)
    Legacy_information: [Joel H. Rothman] Similar to the transcriptional activator pur-alpha (pur-alpha like protein)
    Strain: WBStrain00002953
      WBStrain00032403
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog: WBGene00062462 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00028283 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00122930 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00144644 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00164802 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00232819 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10856 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g8680 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g16172 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g17273 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g6311 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g24367 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g8044 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g16176 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g1003 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9760 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1384 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00189.g6620 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-plp-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g21219 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00007.g543 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_12896 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_013983 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g03045 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_40304500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g10880 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00241597 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00277132 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00285762 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0022361 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1478 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040624-8 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-141216-78 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060531-100 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-070702-3 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:9701 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:9702 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:17930 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:103079 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1338779 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1922279 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1305088 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1559465 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00008976 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: plp-1 encodes a protein containing three PUR repeats that has similarity to the mammalian transcription factor pur alpha; plp-1 is required for embryonic development, development of the pharynx, and formation of the intestine; PLP-1 interacts with double-stranded DNA and specifically, with a Lef-1 binding site within the end-1 promoter; PLP-1 DNA binding is regulated by phosphorylation. Paper_evidence: WBPaper00006241
            WBPaper00032400
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 17 Jun 2011 00:00:00
      Automated_description: Enables double-stranded telomeric DNA binding activity. Involved in germ cell development and regulation of locomotion. Located in P granule and nucleus. Expressed in several structures, including Caa; Cpa; Psub4; oocyte; and somatic cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 31. Is an ortholog of human PURB (purine rich element binding protein B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070061 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9701)
  Molecular_info: Corresponding_CDS: F45E4.2
    Corresponding_transcript: F45E4.2.1
    Other_sequence (78)
    Associated_feature: WBsf646102
      WBsf660319
      WBsf978529
      WBsf981787
      WBsf228556
      WBsf228557
      WBsf228558
    Gene_product_binds: WBsf038804
    Transcription_factor: WBTranscriptionFactor000127
  Experimental_info: RNAi_result (41)
    Expr_pattern (14)
    Drives_construct: WBCnstr00003459
      WBCnstr00011658
      WBCnstr00035723
      WBCnstr00042523
    Construct_product: WBCnstr00011658
      WBCnstr00035723
      WBCnstr00042523
    Regulate_expr_cluster: WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060526:plp-1(ok2155)_upregulated
    Antibody: WBAntibody00001881
      WBAntibody00002923
    Microarray_results (23)
    Expression_cluster (155)
    Interaction (72)
  Map_info: Map: IV Position: 3.36566 Error: 0.000571
    Positive: Positive_clone: F45E4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Sequence connection from [Rothman JH]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene