rpl-7A encodes a large ribosomal subunit L7a protein required in mass RNAi assays for fertility, vulval development, and general health; the rpl-7A transcription unit has one nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-7A is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-10, rpl-12) have protein products that are involved in translation; RPL-7A binds bovine calmodulin in vitro in a calcium-dependent manner.
Enables calmodulin binding activity. Predicted to be involved in maturation of LSU-rRNA. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is an ortholog of human RPL7A (ribosomal protein L7a).
This gene previously was known as rpl-8 with rpl-7A as an other name. Following advice from the CGC, this situation has been reversed and rpl-7A is now the main (CGC approved) name for this gene [040706 krb]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.