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WormBase Tree Display for Gene: WBGene00004829

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Name Class

WBGene00004829SMapS_parentSequenceM02A10
IdentityVersion1
NameCGC_namesli-1Person_evidenceWBPerson625
Sequence_nameM02A10.3
Molecular_nameM02A10.3a
M02A10.3a.1
CE25058
M02A10.3b
CE27393
M02A10.3c
CE37131
M02A10.3b.1
M02A10.3c.1
Other_nameCELE_M02A10.3Accession_evidenceNDBBX284606
Public_namesli-1
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsli
Allele (90)
Legacy_information[Yoon CH] positive clone restores Vul phenotype, suppresses hyperinduction. [injected into animals of the genotype let-23(sy1); sli-1(sy143) and let-23(sy1); sli-1(sy129)].
[C.elegansII] sy143 : suppressor of vulvaless phenotype of let-23 hypomorph; other let-23 defects suppressed, but not sterility; multivulva phenotype in combination with unc-101; low penetrance head morphology defect in let-23(+) background. sy143/Df similar. OA>10: sy263 (weaker), sy129 etc. Cloned: encodes homolog of mammalian oncogene c-cbl (55% identity over 390 aa, containing RING finger motif. sy129 missense. [Jongeward et al. 1995; Yoon et al. 1995; PS]
StrainWBStrain00027422
WBStrain00030821
WBStrain00030825
WBStrain00030829
WBStrain00030830
WBStrain00030836
WBStrain00030870
RNASeq_FPKM (74)
GO_annotation (19)
OrthologWBGene00060243Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00029983Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00113114Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WormBase-Compara
WBGene00130322Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00192634Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00225322Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g3545Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g2884Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g1902Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g13408Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP31.g11483Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g16583Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g15651Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g9808Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g4243Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00309.g8969Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-sli-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g15638Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_01910.g23835Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_03213Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_022194Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g00991Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g22527Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_X0017900Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrX_pilon.g18318Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00242309Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00264480Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00266692Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00291901Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0020224Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-041114-207Danio rerioFrom_analysisHieranoid
Inparanoid
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-030616-417Danio rerioFrom_analysisHieranoid
Inparanoid
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-080220-20Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoInspector
Panther
HGNC:1541Homo sapiensFrom_analysisHieranoid
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:1542Homo sapiensFrom_analysisHieranoid
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:15961Homo sapiensFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
Panther
MGI:88279Mus musculusFrom_analysisHieranoid
Inparanoid
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1931457Mus musculusFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
Panther
MGI:2146430Mus musculusFrom_analysisHieranoid
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:620535Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1307651Rattus norvegicusFrom_analysisEnsEMBL-Compara
OMA
OrthoFinder
Panther
RGD:1561386Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OrthoInspector
Panther
PhylomeDB
SonicParanoid
Structured_descriptionConcise_descriptionsli-1 encodes the C. elegans ortholog of the Cbl family of ubiquitin ligases; sli-1 was originally identified as a suppressor of a hypomorphic mutation in LET-23/EGFR and thus, is predicted to function as a negative regulator of LET-23-mediated signaling; genetic analyses place sli-1 upstream of let-60/Ras; a chimeric protein substituting human SH2 and RING finger domains for those of SLI-1 is partially functional for regulating vulval differentiation in vivo; sli-1(RNAi) in the background of a let-756/FGF mutant results in slow growing animals.Paper_evidenceWBPaper00002148
WBPaper00002227
WBPaper00004417
WBPaper00027336
WBPaper00031036
Curator_confirmedWBPerson1843
Date_last_updated31 Oct 2008 00:00:00
Automated_descriptionPredicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of vulval development. Predicted to be located in membrane raft and plasma membrane. Expressed in several structures, including anal depressor muscle; body wall musculature; distal tip cell; head; and intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung squamous cell carcinoma. Is an ortholog of human CBL (Cbl proto-oncogene); CBLB (Cbl proto-oncogene B); and CBLC (Cbl proto-oncogene C).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (12)
Molecular_infoCorresponding_CDSM02A10.3a
M02A10.3b
M02A10.3c
Corresponding_transcriptM02A10.3a.1
M02A10.3b.1
M02A10.3c.1
Other_sequence (32)
Associated_feature (11)
Experimental_infoRNAi_result (14)
Expr_patternExpr10710
Expr1010899
Expr1032403
Expr1154494
Expr2015883
Expr2034116
Drives_constructWBCnstr00017482
WBCnstr00035358
Construct_productWBCnstr00017482
WBCnstr00035358
Microarray_results (34)
Expression_cluster (128)
Interaction (99)
WBProcessWBbiopr:00000071
Map_infoMapXPosition-19.5052Error0.003049
Well_ordered
PositivePositive_clone (2)
NegativeNegative_cloneF02G3
F25E2
F25H6
Mapping_dataMulti_point2319
2320
4971
Pos_neg_data5879
6860
6861
6862
Reference (71)
MethodGene