sng-1 encodes the C. elegans synaptogyrin ortholog, a vertebrate integral membrane synaptic vesicle protein; loss-of-function mutations in sng-1 result in no obvious defects in synaptogenesis or neuronal activity, suggesting that SNG-1 is likely required for more subtle neuronal functions; SNG-1::GFP reporters are expressed throughout the nervous system in neurons in the dorsal and ventral nerve cords, as well as the anterior nerve ring; SNG-1 colocalizes with the synaptic vesicle component SNT-1.
Predicted to be involved in regulation of exocytosis and synaptic vesicle transport. Located in synaptic vesicle. Expressed in muscle cell and nervous system. Is an ortholog of human SYNGR1 (synaptogyrin 1); SYNGR2 (synaptogyrin 2); and SYNGR4 (synaptogyrin 4).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.