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WormBase Tree Display for Gene: WBGene00006537

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Name Class

WBGene00006537SMapS_parentSequenceC36E8
IdentityVersion1
NameCGC_nametbb-2
Sequence_nameC36E8.5
Molecular_nameC36E8.5
C36E8.5.1
CE00913
Other_nameTUBB8
rot-2CGC_data_submission
CELE_C36E8.5Accession_evidenceNDBBX284603
Public_nametbb-2
DB_infoDatabaseAceViewgene3F106
WormQTLgeneWBGene00006537
WormFluxgeneWBGene00006537
NDBlocus_tagCELE_C36E8.5
PanthergeneCAEEL|WormBase=WBGene00006537|UniProtKB=P52275
familyPTHR11588
NCBIgene175519
RefSeqproteinNM_065405.8
SwissProtUniProtAccP52275
UniProt_GCRPUniProtAccP52275
OMIMgene602661
616768
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classtbb
Allele (24)
Legacy_information[C.elegansII] NMK. Encodes beta tubulin. [NW]
[Schnabel H] maternal-effect embryonic lethal with defect in rotation of centrosome pair and associated pronuclei before first cleavage
Strain (21)
RNASeq_FPKM (74)
GO_annotation (21)
OrthologWBGene00061602Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00031283Caenorhabditis briggsaeFrom_analysisOrthoMCL
WBGene00036174Caenorhabditis briggsaeFrom_analysisOrthoMCL
WBGene00036628Caenorhabditis briggsaeFrom_analysisOrthoMCL
WBGene00037763Caenorhabditis briggsaeFrom_analysisOrthoMCL
WBGene00039237Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00055813Caenorhabditis remaneiFrom_analysisOMA
WBGene00142898Caenorhabditis brenneriFrom_analysisOMA
WBGene00162848Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00125345Caenorhabditis japonicaFrom_analysisInparanoid_8
WormBase-Compara
WBGene00227844Brugia malayiFrom_analysisWormBase-Compara
WBGene00229106Brugia malayiFrom_analysisWormBase-Compara
WBGene00229959Brugia malayiFrom_analysisWormBase-Compara
WBGene00231870Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g12826Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g1048Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g1279Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g6587Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g6588Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g1385Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g17043Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g11749Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g21450Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP38.g2194Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP38.g3162Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g17726Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g16830Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00098.g4277Caenorhabditis angariaFrom_analysisWormBase-Compara
Cang_2012_03_13_07262.g20791Caenorhabditis angariaFrom_analysisWormBase-Compara
Cnig_chr_III.g11284Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g17500Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_01857.g23541Caenorhabditis sinicaFrom_analysisWormBase-Compara
Csp5_scaffold_01857.g23546Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_19906Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_008861Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g03464Oscheius tipulaeFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g09424Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g12944Panagrellus redivivusFrom_analysisWormBase-Compara
Pan_g5597Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_10171810Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_30002600Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_40313700Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIII_pilon.g7356Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00240219Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00240941Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00240944Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00241678Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00245885Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00249139Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00257786Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00259621Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00260020Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00262560Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00262599Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00263629Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00291868Trichuris murisFrom_analysisWormBase-Compara
WBGene00292922Trichuris murisFrom_analysisWormBase-Compara
WBGene00294034Trichuris murisFrom_analysisWormBase-Compara
WBGene00294035Trichuris murisFrom_analysisWormBase-Compara
SGD:S000001857Saccharomyces cerevisiaeFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
FB:FBgn0003890Drosophila melanogasterFrom_analysisEnsEMBL-Compara
OMA
OrthoFinder
Panther
PhylomeDB
ZFIN:ZDB-GENE-070424-195Danio rerioFrom_analysisEnsEMBL-Compara
Panther
HGNC:20772Homo sapiensFrom_analysisEnsEMBL-Compara
Panther
HGNC:20776Homo sapiensFrom_analysisEnsEMBL-Compara
Panther
HGNC:24983Homo sapiensFrom_analysisEnsEMBL-Compara
Panther
HGNC:20773Homo sapiensFrom_analysisEnsEMBL-Compara
Panther
MGI:107813Mus musculusFrom_analysisEnsEMBL-Compara
Panther
MGI:1915201Mus musculusFrom_analysisEnsEMBL-Compara
Panther
RGD:628595Rattus norvegicusFrom_analysisEnsEMBL-Compara
Panther
RGD:1305887Rattus norvegicusFrom_analysisEnsEMBL-Compara
Panther
Paralog (16)
Structured_descriptionConcise_descriptiontbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis.Paper_evidence (11)
Person_evidenceWBPerson399
Curator_confirmedWBPerson48
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in meiotic spindle organization. Located in spindle microtubule. Expressed in several structures, including germ line; gonad; oocyte; tail; and touch receptor neurons. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Is an ortholog of several human genes including TUBB3 (tubulin beta 3 class III); TUBB6 (tubulin beta 6 class V); and TUBB8B (tubulin beta 8B).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0090137Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20772)
DOID:0081017Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20772)
EFO:MONDO:0014769Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20773)
Molecular_infoCorresponding_CDSC36E8.5
Corresponding_transcriptC36E8.5.1
Other_sequence (265)
Associated_feature (13)
Experimental_infoRNAi_result (50)
Expr_pattern (12)
Drives_constructWBCnstr00002578
WBCnstr00034316
WBCnstr00039276
Construct_product (15)
AntibodyWBAntibody00000703
WBAntibody00000712
WBAntibody00002338
Microarray_results (26)
Expression_cluster (206)
Interaction (328)
Map_infoMapIIIPosition-4.0282Error0.006633
PositivePositive_cloneC36E8Inferred_automaticallyFrom sequence, transcript, pseudogene data
NW#B8
Mapping_dataMulti_point4052
4053
4627
5482
5499
Reference (92)
RemarkSequence connection updated based on email from Chenggang Lu
cgc3909 linked tbb-2 to B0272.1, which is not approved by CGCCGC_data_submission
MethodGene