wdr-23 encodes a WD40 repeat-containing protein; WDR-23 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that negatively regulates accumulation and hence, transcriptional activation activity of the SKN-1 transcription factor in intestinal nuclei; wdr-23 activity is thus required for regulation of stress resistance, longevity, and normal growth and development; WDR-23 physically interacts with DDB-1 and SKN-1, thus likely serving as a bridge between the ubiquitin ligase complex and its SKN-1 substrate; in regulating skn-1 function, wdr-23 appears to act downstream of the p38 MAPK pathway and together with gsk-3 and the daf-2-mediated insulin signaling pathway; WDR-23 is expressed in the intestine, hypodermis, and neurons, where it localizes to nuclei.
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in several cellular components, including intracellular membrane-bounded organelle; neuronal cell body; and striated muscle dense body. Expressed in ASIL; ASIR; head; muscle cell; and tail. Is an ortholog of human DCAF11 (DDB1 and CUL4 associated factor 11).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.