F59A2.5 encodes a moderately small (123-residue) protein; F59A2.5 isorthologous to Brugia 14979.m04575, and more distantly similar tobudding yeast Pcc1p, to human CTAG1B (OMIM:300156, cancer antigen),CTAG2 (OMIM:300396, melanoma antigen), and LAGE3 (OMIM:300060), and tomany other uncharacterized proteins, ~80-200 residues long, in animals,fungi, and plants; F59A2.5 is required for fertility and embryonicdevelopment in mass RNAi assays and is bound by CKU-80 in two-hybridassays; F59A2.5 is transcriptionally activated by HLH-2 and HLH-8, buthas no known expression pattern; while F59A2.5 is putatively secretedand its human homologs are antigens, its yeast homolog Pcc1p is thoughtto be a transcription factor.
Predicted to be involved in tRNA threonylcarbamoyladenosine metabolic process. Predicted to be part of EKC/KEOPS complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 2. Is an ortholog of human LAGE3 (L antigen family member 3).