WormBase Tree Display for Gene: WBGene00020490

WBGene00020490 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: tmc-1 Person_evidence: WBPerson260
      Sequence_name: T13G4.3
      Molecular_name: T13G4.3
        T13G4.3.1
        CE37147
        T13G4.3.2
      Other_name: R193.f Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        T13G4.e Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_T13G4.3 Accession_evidence: NDB BX284606
      Public_name: tmc-1
    DB_info: Database: AceView gene XB793
        WormQTL gene WBGene00020490
        WormFlux gene WBGene00020490
        NDB locus_tag CELE_T13G4.3
        Panther gene CAEEL|WormBase=WBGene00020490|UniProtKB=D3KZG3
          family PTHR23302
        NCBI gene 188483
        RefSeq protein NM_075820.9
        SwissProt UniProtAcc D3KZG3
        UniProt_GCRP UniProtAcc D3KZG3
        OMIM gene 606706
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 20 Apr 2011 10:05:24 WBPerson2970 Name_change: CGC_name: tmc-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tmc
    Allele (278)
    Strain: WBStrain00032242
      WBStrain00004936
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog: WBGene00026875 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00060161 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00143063 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00134105 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00089811 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
      WBGene00226036 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2743 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g212 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g799 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP29.g20764 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g6111 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP38.g6065 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9826 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g11189 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00001.g38 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_X.g22183 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold514.g2612 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01236.g19476 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03138 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_022273 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01456 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_X0010400 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g18393 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00239930 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00089810 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00257734 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00287184 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0267796 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060526-261 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060526-262 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060526-280 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:16513 Homo sapiens From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
      HGNC:16527 Homo sapiens From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:22995 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2151016 Mus musculus From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
      MGI:2151017 Mus musculus From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
      MGI:2669033 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1308063 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1310073 Rattus norvegicus From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
      RGD:1308682 Rattus norvegicus From_analysis: Hieranoid
            OrthoFinder
            Panther
    Paralog: WBGene00015177 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: tmc-1 encodes a multipass transmembrane protein; TMC-1 functions specifically as a sodium-sensitive channel that is required for salt taste chemosensation in the ASH neurons and for high salt avoidance behavior; when expressed in other neurons, TMC-1 is sufficient to generate a salt response in vivo, and when expressed in mammalian cells, TMC-1 generates a predominantly cationic current activated by high extracellular sodium but not other cations or uncharged small molecules; tmc-1 is expressed in sensory neurons, including the ASH, ADF, ASE, ADL, AQR, PQR, URX, and PHA neurons and also at lower frequency in AWC, AFD, and BAG; in ASH, TMC-1 localizes to the cell soma as well as the sensory cilium. Paper_evidence: WBPaper00041946
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Feb 2013 00:00:00
      Automated_description: Enables sodium channel activity. Involved in detection of stimulus involved in sensory perception; monoatomic ion transmembrane transport; and sensory perception of chemical stimulus. Located in neuronal cell body; non-motile cilium; and plasma membrane. Expressed in body wall musculature; neurons; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Is an ortholog of human TMC3 (transmembrane channel like 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110520 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16513)
      DOID:10003 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16513)
      DOID:0110563 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16513)
  Molecular_info: Corresponding_CDS: T13G4.3
    Corresponding_CDS_history: T13G4.3:wp88
      T13G4.3:wp128
    Corresponding_transcript: T13G4.3.1
      T13G4.3.2
    Other_sequence (22)
    Associated_feature (14)
  Experimental_info: RNAi_result: WBRNAi00018692 Inferred_automatically: RNAi_primary
      WBRNAi00053286 Inferred_automatically: RNAi_primary
      WBRNAi00017899 Inferred_automatically: RNAi_primary
    Expr_pattern (13)
    Drives_construct: WBCnstr00009854
      WBCnstr00017536
      WBCnstr00020650
      WBCnstr00025101
      WBCnstr00040831
      WBCnstr00042184
      WBCnstr00042981
    Construct_product: WBCnstr00017537
      WBCnstr00025101
      WBCnstr00040715
    Regulate_expr_cluster: WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065746:tmc-1(rg1003)_upregulated
    Microarray_results (19)
    Expression_cluster (143)
    Interaction (13)
    Anatomy_function: WBbtf0953
      WBbtf0954
      WBbtf0956
  Map_info: Map: X Position: -18.4825
    Positive: Positive_clone: T13G4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (19)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene