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WormBase Tree Display for Gene: WBGene00003166

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Name Class

WBGene00003166SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namemec-2Person_evidenceWBPerson95
Sequence_nameF14D12.4
Molecular_name (51)
Other_nameCELE_F14D12.4Accession_evidenceNDBBX284606
Public_namemec-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:31WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmec
Allele (374)
Legacy_informationSee also e75, e1084, e1514
[C.elegansII] u8amb : touch insensitive; lethargic. ES2. ME?. OA>50: e75 (recessive, ME3), u7cs, e1084 (probable null), e1514, e1608dm, u284sd, etc. Alleles vary in phenotype from weak recessive to strong dominant Mec; complex complementation. Cloned: encodes predicted 440 aa protein with central similarity to human stomatin (65% identity over 247 aa). mec-2:lacZ expressed in cell bodies and processes of touch cells, some other neurons.??? [Chalfie and Au 1989; Huang et al. 1995; TU]
StrainWBStrain00002820
WBStrain00037747
WBStrain00004463
WBStrain00004092
RNASeq_FPKM (74)
GO_annotation (26)
Ortholog (36)
ParalogWBGene00006761Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006068Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006065Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006741Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006064Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006063Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006067Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006066Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006061Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionThe mec-2 gene encodes a stomatin homolog required to sense gentle mechanical stimuli (e.g. touch) along the body wall.Paper_evidenceWBPaper00005127
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables cholesterol binding activity. Involved in positive regulation of multicellular organismal process and response to mechanical stimulus. Located in neuron projection membrane. Expressed in sensory neurons. Used to study nephrotic syndrome. Is an ortholog of human STOM (stomatin).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1184Homo sapiensPaper_evidenceWBPaper00044961
Accession_evidenceOMIM600995
Curator_confirmedWBPerson324
Date_last_updated25 Sep 2018 00:00:00
Models_disease_in_annotationWBDOannot00000328
Molecular_infoCorresponding_CDS (17)
Corresponding_transcript (17)
Other_sequenceMAC01381_1
FF679952.1
Hbac_isotig01653
Tcir_isotig31574
MIC00344_1
BMC13599_1
BMC02358_1
FC554053.1
GRC04865_1
JI477273.1
FC546260.1
NBC08840_1
JO468600.1
MH01445
TSC06927_1
Acan_isotig04534
FF680235.1
Dviv_isotig22388
MI06805
GR977180.1
FC544080.1
DAC00932_1
CR06338
Tcol_isotig17311
HBC01874_1
SC00509
EX912633.1
XI00375
ES411507.1
Acan_isotig06423
SS01733
HBC18275_1
Hbac_isotig05907
TSC02509_1
MA02051
EX012048.1
EY469514.1
MIC05231_1
JI178431.1
CRC01911_1
TS02402
ACC01856_1
HG00878
FF680327.1
Dviv_isotig22389
JI175625.1
EX013463.1
MHC00682_1
HBC00410_1
Dviv_isotig18454
TS00530
PSC02902_1
HGC02865_1
Tcir_isotig26399
SSC00071_1
BM01275
MHC00188_1
FF680003.1
PP01223
BUC01324_1
DA05299
Hbac_isotig03790
BMC11860_1
SRC01331_1
EX913662.1
HBC08227_1
MH07708
Acan_isotig04533
ES410250.1
GW410777.1
Oden_isotig26555
Dviv_isotig20743
HG10933
PPC00197_1
NB08743
HGC08728_1
Acan_isotig06424
Oden_isotig22546
OOC02700_1
MH03102
Dviv_isotig18455
ES563491.1
XIC02352_1
Tcol_isotig13095
HBC02813_1
HG03281
Associated_feature (17)
Experimental_infoRNAi_resultWBRNAi00027647Inferred_automaticallyRNAi_primary
WBRNAi00013263Inferred_automaticallyRNAi_primary
WBRNAi00044585Inferred_automaticallyRNAi_primary
Expr_pattern (18)
Drives_constructWBCnstr00003347
WBCnstr00004794
WBCnstr00010333
WBCnstr00011303
WBCnstr00011304
WBCnstr00036204
WBCnstr00042668
WBCnstr00042669
Construct_productWBCnstr00010333
WBCnstr00011303
WBCnstr00036204
AntibodyWBAntibody00000792
WBAntibody00000793
WBAntibody00001354
WBAntibody00001686
WBAntibody00002696
Microarray_results (40)
Expression_cluster (164)
Interaction (81)
WBProcessWBbiopr:00000002
Map_infoMapXPosition-4.70552Error0.075755
Well_ordered
PositivePositive_clone (2)
NegativeOutside_rearrmcDf2
Mapping_dataMulti_point (11)
Pos_neg_data940
1832
3193
500
10696
Reference (113)
RemarkUpdated positive clone to correspond to the sequenced clone instead of just W05G12
MethodGene