WormBase Tree Display for Gene: WBGene00006760
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WBGene00006760 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_V | ||||
Identity | Version | 2 | |||||
Name | CGC_name | unc-23 | Person_evidence | WBPerson261 | |||
Sequence_name | H14N18.1 | ||||||
Molecular_name | H14N18.1a | ||||||
H14N18.1a.1 | |||||||
CE17973 | |||||||
H14N18.1b | |||||||
CE33124 | |||||||
H14N18.1c | |||||||
CE37777 | |||||||
H14N18.1b.1 | |||||||
H14N18.1c.1 | |||||||
Other_name | vab-4 | ||||||
bag-2 | Paper_evidence | WBPaper00048629 | |||||
CELE_H14N18.1 | Accession_evidence | NDB | BX284605 | ||||
Public_name | unc-23 | ||||||
DB_info | Database | AceView | gene | 5J419 | |||
WormQTL | gene | WBGene00006760 | |||||
WormFlux | gene | WBGene00006760 | |||||
NDB | locus_tag | CELE_H14N18.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00006760|UniProtKB=O61980 | |||||
family | PTHR12334 | ||||||
NCBI | gene | 179272 | |||||
RefSeq | protein | NM_072906.7 | |||||
NM_182342.6 | |||||||
NM_001392570.1 | |||||||
TREEFAM | TREEFAM_ID | TF102012 | |||||
TrEMBL | UniProtAcc | Q5TKA9 | |||||
Q86S24 | |||||||
O61980 | |||||||
UniProt_GCRP | UniProtAcc | O61980 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00142919 | ||||||
Allele (62) | |||||||
Legacy_information | e25 : `benthead' progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally hence very poor forward movement good reverse movement. Egl. ES3 (adult) ME1. NA8 (e324 : resembles e25; e611 (pka vab-4 : incompletely penetrant allele) etc.). | ||||||
See also e25, e462, e478, e611, e621, e988, e1182, e2154 | |||||||
[C.elegansII] e25 : "benthead" phenotype, progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally, hence very poor forward movement, good reverse movement; defects in muscle attachment (Mua); Egl. Phenotype partly suppressed by growth in liquid. ES3 (adult) ME1. OA>10: e324 (resembles e25), e611 (pka vab-4, impenetrant allele), e988, e2154 etc. [Waterston et al. 1980; CB; DR; NJ] | |||||||
Strain | WBStrain00032000 | ||||||
WBStrain00033526 | |||||||
WBStrain00034712 | |||||||
WBStrain00003976 | |||||||
WBStrain00003958 | |||||||
WBStrain00004081 | |||||||
WBStrain00004149 | |||||||
WBStrain00004186 | |||||||
WBStrain00005873 | |||||||
WBStrain00005890 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (15) | |||||||
Ortholog (36) | |||||||
Structured_description | Concise_description | unc-23 encodes a protein with similarity to the BAG2 (BCL2 AnthaGene) protein that functions to negatively regulate proteosomal degradation by the E3 ubiquitin ligase and Hsp70 co-chaperone CHIP (Carboxyl-terminus of Hsp70 Interacting Protein); in C. elegans, unc-23 is required for proper attachment of the anterior body wall musculature to the overlying hypodermis. | Paper_evidence | WBPaper00040313 | |||
WBPaper00000461 | |||||||
WBPaper00003943 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 29 Oct 2015 00:00:00 | ||||||
Automated_description | Enables ATPase activator activity and heat shock protein binding activity. Acts upstream of with a positive effect on muscle attachment. Located in M band; nucleolus; and striated muscle dense body. Expressed in several structures, including anal depressor muscle; excretory canal; pharynx; touch receptor neurons; and vulva. Is an ortholog of human BAG2 (BAG cochaperone 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | H14N18.1a | |||||
H14N18.1b | |||||||
H14N18.1c | |||||||
Corresponding_transcript | H14N18.1a.1 | ||||||
H14N18.1b.1 | |||||||
H14N18.1c.1 | |||||||
Other_sequence | Tcol_isotig09902 | ||||||
NBC00986_1 | |||||||
CB038478.1 | |||||||
Dviv_isotig16201 | |||||||
BXC01985_1 | |||||||
CJC03080_1 | |||||||
NB06408 | |||||||
Dviv_isotig16200 | |||||||
CBC14675_1 | |||||||
TDC00875_1 | |||||||
NB06690 | |||||||
Associated_feature | WBsf647031 | ||||||
WBsf647032 | |||||||
WBsf661014 | |||||||
WBsf661015 | |||||||
WBsf661510 | |||||||
WBsf981973 | |||||||
WBsf232176 | |||||||
WBsf232177 | |||||||
WBsf232178 | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern | Expr11891 | ||||||
Expr12480 | |||||||
Expr1012508 | |||||||
Expr1032833 | |||||||
Expr1153142 | |||||||
Expr2017856 | |||||||
Expr2035992 | |||||||
Drives_construct | WBCnstr00019716 | ||||||
WBCnstr00019717 | |||||||
WBCnstr00034167 | |||||||
Construct_product | WBCnstr00021438 | ||||||
WBCnstr00034167 | |||||||
Microarray_results (28) | |||||||
Expression_cluster (192) | |||||||
Interaction (27) | |||||||
Map_info | Map | V | Position | 1.8633 | Error | 0.014042 | |
Well_ordered | |||||||
Positive | Inside_rearr | mDf1 | |||||
sDf29 | |||||||
Positive_clone | H14N18 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Negative | Outside_rearr | nDf42 | |||||
Mapping_data | 2_point | 129 | |||||
840 | |||||||
841 | |||||||
Multi_point (26) | |||||||
Pos_neg_data (12) | |||||||
Reference (57) | |||||||
Remark | Sequence connection from [Rahmani P, Moerman DG] | ||||||
Method | Gene |