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WormBase Tree Display for Gene: WBGene00015399

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WBGene00015399	SMap	S_parent	Sequence	C03G6
	Identity	Version	2
		Name	CGC_name	cyp-35A1
			Sequence_name	C03G6.14
			Molecular_name	C03G6.14
				C03G6.14.1
				CE52081
			Other_name	CELE_C03G6.14	Accession_evidence	NDB	BX284605
			Public_name	cyp-35A1
		DB_info	Database	AceView	gene	5H838
				WormQTL	gene	WBGene00015399
				WormFlux	gene	WBGene00015399
				NDB	locus_tag	CELE_C03G6.14
				Panther	gene	CAEEL\|WormBase=WBGene00015399\|UniProtKB=O02627
					family	PTHR24300
				NCBI	gene	182176
				RefSeq	protein	NM_001356694.2
				TrEMBL	UniProtAcc	O02627
				UniProt_GCRP	UniProtAcc	O02627
		Species	Caenorhabditis elegans
		History	Version_change	1	28 May 2004 13:30:56	WBPerson1971	Event	Imported	Initial conversion from CDS class of stlace from WS125
				2	21 Sep 2004 09:38:16	WBPerson1971	Name_change	CGC_name	cyp-35A1
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	cyp
		Allele (40)
		Strain	WBStrain00032479
			WBStrain00036139
		RNASeq_FPKM (74)
		GO_annotation (15)
		Ortholog (129)
		Paralog	WBGene00000373	Caenorhabditis elegans	From_analysis	TreeFam
			WBGene00000905	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00007362	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00007913	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00008829	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00010589	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00010705	Caenorhabditis elegans	From_analysis	TreeFam
			WBGene00010706	Caenorhabditis elegans	From_analysis	TreeFam
			WBGene00010707	Caenorhabditis elegans	From_analysis	TreeFam
			WBGene00011009	Caenorhabditis elegans	From_analysis	TreeFam
			WBGene00011698	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00011699	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00012448	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015040	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015041	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015042	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015043	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015044	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015045	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015135	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00018334	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00019472	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015709	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00016686	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00016860	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00018262	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00018264	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00018413	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00019967	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00021168	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00021710	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00016697	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00018261	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00016768	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00016092	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00018260	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00019565	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015400	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00019470	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00019471	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00019473	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00016786	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00020386	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00018333	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Concise_description	cyp-35A1 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35A1 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; inaddition, cyp-35A(RNAi) also results in a reduction of fat content.	Paper_evidence	WBPaper00005655
						WBPaper00025207
					Curator_confirmed	WBPerson1843
					Date_last_updated	26 Feb 2009 00:00:00
			Automated_description	Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2E1 (cytochrome P450 family 2 subfamily E member 1).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model (42)
	Molecular_info	Corresponding_CDS	C03G6.14
		Corresponding_CDS_history	C03G6.14:wp125
			C03G6.14:wp185
			C03G6.14:wp261
		Corresponding_transcript	C03G6.14.1
		Other_sequence	Dviv_isotig14097
			Dviv_isotig14098
			AM743893.1
			Oden_isotig18384
	Experimental_info	RNAi_result	WBRNAi00078473	Inferred_automatically	RNAi_primary
			WBRNAi00078474	Inferred_automatically	RNAi_primary
			WBRNAi00039542	Inferred_automatically	RNAi_primary
			WBRNAi00010067	Inferred_automatically	RNAi_primary
			WBRNAi00114817	Inferred_automatically	RNAi_primary
			WBRNAi00092681	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr1017756
			Expr1143646
			Expr2010734
		Drives_construct	WBCnstr00028874
		Construct_product	WBCnstr00028874
		Microarray_results (15)
		Expression_cluster (111)
		Interaction (28)
	Map_info	Map	V	Position	0.708623	Error	0.002847
		Positive	Positive_clone	C03G6	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	5576
		Pseudo_map_position
	Reference (11)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene