plp-1 encodes a protein containing three PUR repeats that has similarity to the mammalian transcription factor pur alpha; plp-1 is required for embryonic development, development of the pharynx, and formation of the intestine; PLP-1 interacts with double-stranded DNA and specifically, with a Lef-1 binding site within the end-1 promoter; PLP-1 DNA binding is regulated by phosphorylation.
Enables double-stranded telomeric DNA binding activity. Involved in germ cell development and regulation of locomotion. Located in P granule and nucleus. Expressed in several structures, including Caa; Cpa; Psub4; oocyte; and somatic cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 31. Is an ortholog of human PURB (purine rich element binding protein B).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.