ptr-10 encodes an ortholog of Drosophila and human PTCHD3, which definesone of seven paralogous families of sterol sensing domain (SSD)proteins; PTR-10 is weakly required for normal molting from L4 to adultstages; however, PTR-10 in conjunction with PTR-1 and PTR-6 is stronglyrequired for both molting and viability, with triple ptr-1/-6/-10 RNAianimals showing pronounced molting defects and lethality.
Involved in molting cycle. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Expressed in accessory cell. Human ortholog(s) of this gene implicated in autistic disorder. Is an ortholog of human PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.