calf-1 encodes a novel Type I transmembrane protein conserved amongst nematodes; CALF-1 is required, along with UNC-36, for proper intracellular trafficking, presynaptic localization, and functional maturation of UNC-2, an alpha 1 subunit of the C. elegans neuronal CaV2 voltage-gated calcium channel, in sensory and motor neurons throughout development; calf-1 also functions in a calcium-dependent pathway that generates left-right asymmetry in the AWC neurons during development; a calf-1::gfp promoter fusion is expressed in many or all neurons, and a CALF-1::GFP reporter fusion localizes to the endoplasmic reticulum.
Involved in determination of left/right asymmetry in nervous system; positive regulation of locomotion; and protein localization. Located in endoplasmic reticulum membrane. Expressed in AWCL and AWCR.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.