asd-1 encodes an ortholog of human RBM9 et al., and paralog of FOX-1 andSPN-4; ASD-1 isoforms have an RNA recognition motif and 1-2glutamine/asparagine-rich domains; ASD-1 and FOX-1 both bind a site inegl-15 mRNA that is required to repress exon 5B splicing into maturemRNA; ASD-1 alone is partly required for exon 5A expression in musclecells, while FOX-1 alone is dispensable for it; double asd-1;fox-1mutants completely fail to express exon 5A in muscle cells, and have asynthetic egl-15 phenotype, while asd-1;spn-4 mutants do not; asd-1 isexpressed pharyngeally.
Enables single-stranded RNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm and nucleus. Expressed in body wall musculature; intestine; nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; hypoplastic left heart syndrome; myotonic dystrophy type 1; and type 2 diabetes mellitus. Is an ortholog of human RBFOX1 (RNA binding fox-1 homolog 1); RBFOX2 (RNA binding fox-1 homolog 2); and RBFOX3 (RNA binding fox-1 homolog 3).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.