aptf-1 encodes one of four C. elegans AP-2-like transcription factors; APTF-1 activity is required in the RIS interneuron for sleep-like quiescence induced by neuropeptide signaling; aptf-1 is expressed in five head interneurons.
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and sleep. Predicted to be located in nucleus. Expressed in head neurons and pharyngeal neurons. Human ortholog(s) of this gene implicated in Char syndrome; branchiooculofacial syndrome; and dilated cardiomyopathy. Is an ortholog of human TFAP2C (transcription factor AP-2 gamma).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.