bus-2 encodes a predicted glycosyltransferase that contains conserved domains of core-1 beta1,3 galactosyltransferases; bus-2 is required for bacterial infection, and for fully normal cuticle integrity; specifically, bus-2 is needed both for colonization by Microbacterium nematophilum (and the tail-swelling response to M. nematophilum infection), and for attachment of Yersinia pseudotuberculosis biofilms; bus-2 mutant animals exhibit defects in core-1 O-glycan synthesis, while also showing a concomitant increase in novel fucosyl O-glycans; a bus-2::RFP reporter is expressed in the posterior intestine as well as the hypodermal seam cells and spermatheca.
Predicted to enable hexosyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in membrane. Expressed in head muscle; intestine; seam cell; and spermatheca.