WormBase Tree Display for Gene: WBGene00000366
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WBGene00000366 | SMap | S_parent | Sequence | R10E11 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name (5) | |||||||||
DB_info | Database (14) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cbp | ||||||||
Allele (120) | |||||||||
Legacy_information | [Mello C] cbp for CBP/p300 related gene. No mutants known. Predicted gene R10E11.1 | ||||||||
Strain | WBStrain00002432 | ||||||||
WBStrain00002490 | |||||||||
WBStrain00040750 | |||||||||
WBStrain00026532 | |||||||||
WBStrain00036243 | |||||||||
WBStrain00040749 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (41) | |||||||||
Ortholog (42) | |||||||||
Paralog | WBGene00010545 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00016220 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00009595 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00016221 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00008209 | Caenorhabditis elegans | From_analysis | Panther | ||||||
Structured_description | Concise_description | cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates. | Paper_evidence | WBPaper00003050 | |||||
WBPaper00005068 | |||||||||
WBPaper00005101 | |||||||||
WBPaper00005137 | |||||||||
WBPaper00012788 | |||||||||
WBPaper00012830 | |||||||||
WBPaper00012882 | |||||||||
WBPaper00012897 | |||||||||
WBPaper00013003 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; histone acetyltransferase activity; and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of distal tip cell migration; and spermatogenesis. Located in cytoplasm and nucleus. Expressed in alimentary system; distal tip cell; head; and tail. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Huntington's disease; Rubinstein-Taybi syndrome; and leukemia (multiple). Is an ortholog of human CREBBP (CREB binding protein). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (16) | ||||||||
Modifies_disease | DOID:10652 | ||||||||
Modifies_disease_in_annotation | WBDOannot00001083 | ||||||||
Molecular_info | Corresponding_CDS | R10E11.1a | |||||||
R10E11.1b | |||||||||
R10E11.1c | |||||||||
Corresponding_CDS_history | R10E11.1a:wp229 | ||||||||
R10E11.1b:wp229 | |||||||||
R10E11.1c:wp229 | |||||||||
Corresponding_transcript | R10E11.1a.1 | ||||||||
R10E11.1a.2 | |||||||||
R10E11.1b.1 | |||||||||
R10E11.1c.1 | |||||||||
Other_sequence (42) | |||||||||
Associated_feature (17) | |||||||||
Transcription_factor | WBTranscriptionFactor000427 | ||||||||
Experimental_info | RNAi_result | WBRNAi00082125 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00104954 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084524 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084559 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104947 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104957 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117552 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084558 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104968 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113353 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113847 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104948 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092182 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104944 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084526 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084516 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082119 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089603 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082120 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066910 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084515 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00112449 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084542 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097498 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101707 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00026076 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084537 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00087889 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00007168 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097500 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117548 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084533 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097494 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084532 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00106748 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084539 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097493 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104963 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082126 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104951 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117547 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00106747 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117551 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104958 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084545 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084528 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104969 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104952 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00006037 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104962 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117553 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113850 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084520 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084538 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117546 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104966 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082116 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104949 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084535 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117550 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00106677 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104950 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104965 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00009058 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084540 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084561 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00034814 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084518 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117555 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104946 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082114 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113352 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104970 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00112447 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084560 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084529 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113351 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084541 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085498 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00111577 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084531 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104967 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082115 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097497 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104960 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00051693 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084546 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097496 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104945 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082113 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097495 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104956 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117542 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089633 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104964 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091049 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084547 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113846 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084642 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117545 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082121 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084517 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117549 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117554 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113848 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00051692 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084536 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00065751 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082127 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097499 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084557 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113354 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084530 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084522 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113849 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117544 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104959 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104955 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104961 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084519 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084527 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084556 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00111742 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117543 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00104953 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113350 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084543 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00112448 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (14) | |||||||||
Drives_construct | WBCnstr00003040 | ||||||||
WBCnstr00003080 | |||||||||
WBCnstr00004515 | |||||||||
WBCnstr00004534 | |||||||||
WBCnstr00005915 | |||||||||
WBCnstr00005916 | |||||||||
WBCnstr00019390 | |||||||||
Construct_product | WBCnstr00005915 | ||||||||
WBCnstr00005916 | |||||||||
WBCnstr00040741 | |||||||||
Antibody | WBAntibody00000452 | ||||||||
WBAntibody00000453 | |||||||||
WBAntibody00002112 | |||||||||
Microarray_results (31) | |||||||||
Expression_cluster (147) | |||||||||
Interaction (302) | |||||||||
WBProcess | WBbiopr:00000070 | ||||||||
Map_info | Map | III | Position | 0.996159 | Error | 0.002046 | |||
Positive | Positive_clone | R10E11 | Person_evidence | WBPerson419 | |||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Mapping_data | Multi_point | 4177 | |||||||
4195 | |||||||||
Pseudo_map_position | |||||||||
Reference (200) | |||||||||
Picture | WBPicture0000013084 | ||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
cep-1 has been used as an unapproved name for what is the CGC approved cbp-1 (R10E11.1). The real CGC approved cep-1 (F52B5.5) is a p53 homolog, whereas the approved cbp-1 is a p300 homolog | Paper_evidence | WBPaper00004757 | |||||||
Method | Gene |