WormBase Tree Display for Gene: WBGene00001049
expand all nodes | collapse all nodes | view schema
WBGene00001049 | SMap | S_parent | Sequence | F33H2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | dog | ||||||
Allele (117) | |||||||
Strain | WBStrain00001778 | ||||||
WBStrain00003477 | |||||||
WBStrain00035483 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (25) | |||||||
Contained_in_operon | CEOP1772 | ||||||
Ortholog (43) | |||||||
Paralog | WBGene00010839 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00009124 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00044493 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00021752 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | dog-1 encodes a helicase homologous to the human FANCJ/BRIP1/BACH1 helicase; DOG-1 is required for interstrand cross-link (ICL) repair and for maintenance of polyguanine tracts of germline and somatic DNA by resolving the secondary structure that can occur in guanine-rich DNA during lagging-strand DNA synthesis; genetic analysis suggests that dog-1 functions downstream of fcd-2 and rad-51 in mediating ICL and that fcd-2 activity is required for G/C tract maintenance in the absence of dog-1. | Paper_evidence | WBPaper00005308 | |||
WBPaper00031336 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson1843 | |||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 25 May 2011 00:00:00 | ||||||
Automated_description | Predicted to enable DNA helicase activity. Involved in DNA metabolic process; regulation of DNA-templated DNA replication; and reproduction. Predicted to be located in nucleus. Expressed in head and tail. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Down syndrome; Fanconi anemia complementation group J; and cervical squamous cell carcinoma. Is an ortholog of human BRIP1 (BRCA1 interacting helicase 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:13636 | Homo sapiens | Paper_evidence | WBPaper00031336 | ||
Accession_evidence | OMIM | 227650 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 05 Mar 2018 00:00:00 | ||||||
Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | |||
DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||
DOID:14250 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||
DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||
DOID:3744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||
DOID:1588 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||
DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||
DOID:0111097 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||
Disease_relevance | Human FANCJ/BRIP1/BACH1 encodes a dead-box helicase and BRCA1-binding protein mutated in Fanconi anemia (FA) and early-onset breast cancer; Fanconi anemia is a disorder characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs); studies in C.elegans indicate that dog-1, the C. elegans functional orthlog of FANCJ, functions to maintain G-rich DNA and reduce ICL-induced damage, together with other FA pathway components. | Homo sapiens | Paper_evidence | WBPaper00041180 | |||
Curator_confirmed | WBPerson324 | ||||||
Models_disease_asserted | WBDOannot00000099 | ||||||
WBDOannot00000493 | |||||||
WBDOannot00000494 | |||||||
Molecular_info | Corresponding_CDS | F33H2.1 | |||||
Corresponding_transcript | F33H2.1.1 | ||||||
Other_sequence (23) | |||||||
Associated_feature | WBsf649787 | ||||||
WBsf665194 | |||||||
WBsf220678 | |||||||
Experimental_info | RNAi_result | WBRNAi00003580 | Inferred_automatically | RNAi_primary | |||
WBRNAi00107692 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00046238 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00031730 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00022764 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00075594 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00116819 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00002389 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00007739 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077836 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00107691 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram442 | ||||||
Chronogram788 | |||||||
Expr5942 | |||||||
Expr5943 | |||||||
Expr1021031 | |||||||
Expr1030661 | |||||||
Expr1150126 | |||||||
Expr2011023 | |||||||
Expr2029260 | |||||||
Drives_construct | WBCnstr00002591 | ||||||
WBCnstr00004379 | |||||||
WBCnstr00037121 | |||||||
Construct_product | WBCnstr00037121 | ||||||
Microarray_results (19) | |||||||
Expression_cluster (140) | |||||||
Interaction | WBInteraction000052805 | ||||||
WBInteraction000052900 | |||||||
WBInteraction000161806 | |||||||
WBInteraction000161819 | |||||||
WBInteraction000163067 | |||||||
WBInteraction000351166 | |||||||
WBInteraction000372486 | |||||||
WBInteraction000441914 | |||||||
WBInteraction000500003 | |||||||
WBInteraction000500004 | |||||||
Map_info | Map | I | Position | 29.4332 | Error | 0.084094 | |
Positive | Positive_clone | F33H2 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4499 | |||||
Pseudo_map_position | |||||||
Reference (50) | |||||||
Remark | Sequence connection from [Cheung I, Schertzer M, Rose A, Lansdorp RM], [020809 krb] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |