Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006433

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006433EvidenceCGC_data_submission
SMapS_parentSequenceF42A8
IdentityVersion2
NameCGC_namesdhb-1Person_evidenceWBPerson205
Sequence_nameF42A8.2
Molecular_nameF42A8.2
F42A8.2.1
CE01579
Other_nametag-55Person_evidenceWBPerson201
CELE_F42A8.2Accession_evidenceNDBBX284602
Public_namesdhb-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
219 Jul 2006 13:35:13WBPerson2970Name_changeCGC_namesdhb-1
Other_nametag-55
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsdhb
Allele (36)
Strain (12)
RNASeq_FPKM (74)
GO_annotation (30)
Ortholog (38)
ParalogWBGene00009626Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionsdhb-1 encodes the C. elegans ortholog of human succinate dehydrogenase subunit B (SDHB; OMIM:185470, mutations lead to extraadrenal pheochromocytoma) which contains several iron-sulfur (Fe-S) clusters and functions to transfer electrons from the A (SDHA) subunit to the membrane-associated C (SDHC) subunit; RNAi screens indicate that sdhb-1 activity is essential for embryonic and larval development, as well as for normal brood sizes, body morphology, osmoregulation, and growth rate; in addition, transgenic animals expressing SDHB-1 variants at the conserved Pro211 residue exhibit various phenotypes, including hypersensitivity to oxidative stress, reduced life span, impaired respiration and excess superoxide production; sdhb-1 is widely expressed in larvae and adults and SDHB-1 localizes to mitochondria.Paper_evidenceWBPaper00004424
WBPaper00005654
WBPaper00005674
WBPaper00006395
WBPaper00006525
WBPaper00024497
WBPaper00024944
WBPaper00032923
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated05 May 2009 00:00:00
Automated_descriptionContributes to succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in aerobic respiration and respiratory electron transport chain. Located in mitochondrion. Expressed in head and tail. Used to study paraganglioma. Human ortholog(s) of this gene implicated in several diseases, including Carney-Stratakis syndrome; gastrointestinal stromal tumor; and mitochondrial complex II deficiency. Is an ortholog of human SDHB (succinate dehydrogenase complex iron sulfur subunit B).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:0050773Homo sapiensPaper_evidenceWBPaper00060158
Curator_confirmedWBPerson324
Date_last_updated21 Jul 2022 00:00:00
Potential_modelDOID:0060537Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10681)
DOID:0080533Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10681)
DOID:0050771Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10681)
DOID:0050773Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10681)
DOID:9253Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10681)
Models_disease_assertedWBDOannot00001290
Molecular_infoCorresponding_CDSF42A8.2
Corresponding_transcriptF42A8.2.1
Other_sequence (195)
Associated_featureWBsf650423
WBsf989031
WBsf1012845
WBsf223637
WBsf223638
WBsf223639
Experimental_infoRNAi_resultWBRNAi00095617Inferred_automaticallyRNAi_primary
WBRNAi00072493Inferred_automaticallyRNAi_primary
WBRNAi00074341Inferred_automaticallyRNAi_primary
WBRNAi00112845Inferred_automaticallyRNAi_primary
WBRNAi00074339Inferred_automaticallyRNAi_primary
WBRNAi00093548Inferred_automaticallyRNAi_primary
WBRNAi00111212Inferred_automaticallyRNAi_primary
WBRNAi00072491Inferred_automaticallyRNAi_primary
WBRNAi00008783Inferred_automaticallyRNAi_primary
WBRNAi00093553Inferred_automaticallyRNAi_primary
WBRNAi00074338Inferred_automaticallyRNAi_primary
WBRNAi00093559Inferred_automaticallyRNAi_primary
WBRNAi00028227Inferred_automaticallyRNAi_primary
WBRNAi00093558Inferred_automaticallyRNAi_primary
WBRNAi00063770Inferred_automaticallyRNAi_primary
WBRNAi00111195Inferred_automaticallyRNAi_primary
WBRNAi00093556Inferred_automaticallyRNAi_primary
WBRNAi00111192Inferred_automaticallyRNAi_primary
WBRNAi00047071Inferred_automaticallyRNAi_primary
WBRNAi00025472Inferred_automaticallyRNAi_primary
WBRNAi00111198Inferred_automaticallyRNAi_primary
WBRNAi00093555Inferred_automaticallyRNAi_primary
WBRNAi00063760Inferred_automaticallyRNAi_primary
WBRNAi00074337Inferred_automaticallyRNAi_primary
WBRNAi00093547Inferred_automaticallyRNAi_primary
WBRNAi00022951Inferred_automaticallyRNAi_primary
WBRNAi00112905Inferred_automaticallyRNAi_primary
WBRNAi00106227Inferred_automaticallyRNAi_primary
WBRNAi00072492Inferred_automaticallyRNAi_primary
WBRNAi00111222Inferred_automaticallyRNAi_primary
WBRNAi00074344Inferred_automaticallyRNAi_primary
WBRNAi00093554Inferred_automaticallyRNAi_primary
WBRNAi00112785Inferred_automaticallyRNAi_primary
WBRNAi00106063Inferred_automaticallyRNAi_primary
WBRNAi00113357Inferred_automaticallyRNAi_primary
WBRNAi00093546Inferred_automaticallyRNAi_primary
WBRNAi00074340Inferred_automaticallyRNAi_primary
WBRNAi00111217Inferred_automaticallyRNAi_primary
WBRNAi00093560Inferred_automaticallyRNAi_primary
WBRNAi00093557Inferred_automaticallyRNAi_primary
WBRNAi00093561Inferred_automaticallyRNAi_primary
WBRNAi00106978Inferred_automaticallyRNAi_primary
WBRNAi00111204Inferred_automaticallyRNAi_primary
WBRNAi00074343Inferred_automaticallyRNAi_primary
WBRNAi00064409Inferred_automaticallyRNAi_primary
WBRNAi00074342Inferred_automaticallyRNAi_primary
Expr_patternChronogram773
Expr6037
Expr1016349
Expr1032613
Expr1150935
Expr2015664
Expr2033897
Drives_constructWBCnstr00003460
WBCnstr00034359
Construct_productWBCnstr00034359
Microarray_results (22)
Expression_cluster (112)
Interaction (129)
Map_infoMapIIPosition1.29106Error0.002149
PositivePositive_cloneF42A8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (17)
RemarkGene name created from parsing 'genotype' field from CGC strain informationCGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene