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WormBase Tree Display for Gene: WBGene00008419

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Name Class

WBGene00008419SMapS_parentSequenceD2030
IdentityVersion3
NameCGC_namewdr-23Person_evidenceWBPerson590
Sequence_nameD2030.9
Molecular_name (16)
Other_namexrep-1Paper_evidenceWBPaper00036411
Person_evidenceWBPerson1284
CELE_D2030.9Accession_evidenceNDBBX284601
Public_namewdr-23
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:49WBPerson1971EventImportedInitial conversion from CDS class of WS125
226 Mar 2007 13:57:19WBPerson2970Name_changeCGC_namewdr-23
301 Oct 2010 14:04:48WBPerson2970Name_changeOther_namexrep-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classwdr
Allele (92)
StrainWBStrain00001583
WBStrain00001735
WBStrain00005859
WBStrain00005861
WBStrain00055405
RNASeq_FPKM (74)
GO_annotation (26)
Contained_in_operonCEOP1408
Ortholog (33)
Structured_descriptionConcise_descriptionwdr-23 encodes a WD40 repeat-containing protein; WDR-23 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that negatively regulates accumulation and hence, transcriptional activation activity of the SKN-1 transcription factor in intestinal nuclei; wdr-23 activity is thus required for regulation of stress resistance, longevity, and normal growth and development; WDR-23 physically interacts with DDB-1 and SKN-1, thus likely serving as a bridge between the ubiquitin ligase complex and its SKN-1 substrate; in regulating skn-1 function, wdr-23 appears to act downstream of the p38 MAPK pathway and together with gsk-3 and the daf-2-mediated insulin signaling pathway; WDR-23 is expressed in the intestine, hypodermis, and neurons, where it localizes to nuclei.Paper_evidenceWBPaper00032980
Curator_confirmedWBPerson1843
Date_last_updated06 Apr 2010 00:00:00
Automated_descriptionEnables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in several cellular components, including intracellular membrane-bounded organelle; neuronal cell body; and striated muscle dense body. Expressed in ASIL; ASIR; head; muscle cell; and tail. Is an ortholog of human DCAF11 (DDB1 and CUL4 associated factor 11).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSD2030.9a
D2030.9b
D2030.9c
D2030.9d
D2030.9e
Corresponding_transcriptD2030.9a.1
D2030.9a.2
D2030.9b.1
D2030.9c.1
D2030.9d.1
D2030.9e.1
Other_sequence (26)
Associated_feature (17)
Experimental_infoRNAi_resultWBRNAi00080771Inferred_automaticallyRNAi_primary
WBRNAi00060418Inferred_automaticallyRNAi_primary
WBRNAi00113798Inferred_automaticallyRNAi_primary
WBRNAi00080777Inferred_automaticallyRNAi_primary
WBRNAi00080781Inferred_automaticallyRNAi_primary
WBRNAi00080780Inferred_automaticallyRNAi_primary
WBRNAi00088146Inferred_automaticallyRNAi_primary
WBRNAi00092743Inferred_automaticallyRNAi_primary
WBRNAi00114486Inferred_automaticallyRNAi_primary
WBRNAi00060412Inferred_automaticallyRNAi_primary
WBRNAi00060414Inferred_automaticallyRNAi_primary
WBRNAi00024958Inferred_automaticallyRNAi_primary
WBRNAi00113319Inferred_automaticallyRNAi_primary
WBRNAi00113090Inferred_automaticallyRNAi_primary
WBRNAi00088228Inferred_automaticallyRNAi_primary
WBRNAi00080766Inferred_automaticallyRNAi_primary
WBRNAi00106801Inferred_automaticallyRNAi_primary
WBRNAi00003290Inferred_automaticallyRNAi_primary
WBRNAi00060419Inferred_automaticallyRNAi_primary
WBRNAi00080753Inferred_automaticallyRNAi_primary
WBRNAi00106800Inferred_automaticallyRNAi_primary
WBRNAi00080756Inferred_automaticallyRNAi_primary
WBRNAi00024957Inferred_automaticallyRNAi_primary
WBRNAi00088054Inferred_automaticallyRNAi_primary
WBRNAi00066175Inferred_automaticallyRNAi_primary
WBRNAi00060415Inferred_automaticallyRNAi_primary
WBRNAi00088269Inferred_automaticallyRNAi_primary
WBRNAi00092742Inferred_automaticallyRNAi_primary
WBRNAi00113800Inferred_automaticallyRNAi_primary
WBRNAi00060413Inferred_automaticallyRNAi_primary
WBRNAi00060420Inferred_automaticallyRNAi_primary
WBRNAi00088310Inferred_automaticallyRNAi_primary
WBRNAi00088392Inferred_automaticallyRNAi_primary
WBRNAi00097072Inferred_automaticallyRNAi_primary
WBRNAi00080774Inferred_automaticallyRNAi_primary
WBRNAi00088095Inferred_automaticallyRNAi_primary
WBRNAi00088441Inferred_automaticallyRNAi_primary
WBRNAi00088115Inferred_automaticallyRNAi_primary
WBRNAi00060417Inferred_automaticallyRNAi_primary
WBRNAi00097077Inferred_automaticallyRNAi_primary
WBRNAi00116912Inferred_automaticallyRNAi_primary
WBRNAi00115100Inferred_automaticallyRNAi_primary
WBRNAi00080779Inferred_automaticallyRNAi_primary
WBRNAi00088187Inferred_automaticallyRNAi_primary
WBRNAi00080750Inferred_automaticallyRNAi_primary
WBRNAi00112401Inferred_automaticallyRNAi_primary
WBRNAi00043478Inferred_automaticallyRNAi_primary
WBRNAi00113144Inferred_automaticallyRNAi_primary
WBRNAi00024956Inferred_automaticallyRNAi_primary
WBRNAi00030405Inferred_automaticallyRNAi_primary
WBRNAi00080769Inferred_automaticallyRNAi_primary
WBRNAi00060416Inferred_automaticallyRNAi_primary
WBRNAi00088351Inferred_automaticallyRNAi_primary
WBRNAi00080778Inferred_automaticallyRNAi_primary
Expr_pattern (17)
Drives_construct (12)
Construct_product (14)
Regulate_expr_clusterWBPaper00042215:wdr-23(tm1817)_downregulated
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00044743:wdr-23_neuron_upregulated
WBPaper00059566:wdr-23(mac32)_downregulated
WBPaper00059566:wdr-23(mac32)_upregulated
Microarray_results (40)
Expression_cluster (155)
Interaction (42)
Map_infoMapIPosition2.19591Error0.005029
PositivePositive_cloneD2030Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (48)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene