WormBase Tree Display for Gene: WBGene00002048
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WBGene00002048 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | B0244 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | ida-1 | Person_evidence | WBPerson71 | |||||
Sequence_name | B0244.2 | ||||||||
Molecular_name | B0244.2 | ||||||||
B0244.2.1 | |||||||||
CE31867 | |||||||||
Other_name | ia2 | Accession_evidence | EMBL | AF126740 | |||||
CELE_B0244.2 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | ida-1 | ||||||||
DB_info | Database | AceView | gene | 3G855 | |||||
WormQTL | gene | WBGene00002048 | |||||||
WormFlux | gene | WBGene00002048 | |||||||
NDB | locus_tag | CELE_B0244.2 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00002048|UniProtKB=G5EGJ5 | |||||||
family | PTHR46106 | ||||||||
NCBI | gene | 175807 | |||||||
RefSeq | protein | NM_065844.7 | |||||||
SwissProt | UniProtAcc | G5EGJ5 | |||||||
TREEFAM | TREEFAM_ID | TF351976 | |||||||
UniProt_GCRP | UniProtAcc | G5EGJ5 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | ida | ||||||||
Allele (167) | |||||||||
Strain | WBStrain00003830 | ||||||||
WBStrain00003831 | |||||||||
WBStrain00003832 | |||||||||
WBStrain00035598 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (39) | |||||||||
Paralog (64) | |||||||||
Structured_description | Concise_description | ida-1 encodes a protein tyrosine phosphatase-like receptor, orthologous to the mammalian type I diabetes autoantigens IA-2 and phogrin that are expressed in dense core vesicles of neuroendocrine tissue and involved in regulated protein secretion; in C. elegans, IDA-1 appears to be required for regulating presynaptic neurotransmission and in particular, for the neuropeptidergic control of egg-laying; ida-1 interacts genetically with unc-31 and unc-64, which encode proteins required for dense core vesicle fusion and exocytosis; ida-1 expression is detected in a subset of neurons in the anterior nerve ring, the ventral nerve cord, the tail, and the vulva, including the VC vulval motoneurons and the HSN egg-laying neurons; ida-1 is also detected in the vulval uv1 cells, non-neuronal cells that contain neurosecretory-like vesicles. | Paper_evidence | WBPaper00004433 | |||||
WBPaper00004518 | |||||||||
WBPaper00019367 | |||||||||
WBPaper00019564 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Involved in positive regulation of anterior/posterior axon guidance; positive regulation of neurotransmitter secretion; and ventral cord development. Located in dense core granule and synapse. Expressed in several structures, including buccal cavity; neurons; preanal ganglion; somatic nervous system; and uv1. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Is an ortholog of human PTPRN2 (protein tyrosine phosphatase receptor type N2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00046108 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 28 Feb 2017 00:00:00 | ||||||||
DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00046108 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 04 Feb 2015 00:00:00 | ||||||||
Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9676,HGNC:9677) | |||||
DOID:11716 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9677) | ||||||
Models_disease_in_annotation | WBDOannot00000345 | ||||||||
WBDOannot00000388 | |||||||||
Molecular_info | Corresponding_CDS | B0244.2 | |||||||
Corresponding_CDS_history | B0244.2:wp86 | ||||||||
B0244.2b:wp18 | |||||||||
Corresponding_transcript | B0244.2.1 | ||||||||
Other_sequence (97) | |||||||||
Associated_feature (18) | |||||||||
Experimental_info | RNAi_result | WBRNAi00000950 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038791 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038790 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00028026 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00009628 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00005822 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00009627 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (14) | |||||||||
Drives_construct (12) | |||||||||
Construct_product | WBCnstr00000646 | ||||||||
WBCnstr00005801 | |||||||||
WBCnstr00006969 | |||||||||
WBCnstr00008654 | |||||||||
WBCnstr00018579 | |||||||||
WBCnstr00036495 | |||||||||
Antibody | WBAntibody00000901 | ||||||||
Microarray_results (21) | |||||||||
Expression_cluster (299) | |||||||||
Interaction (63) | |||||||||
Map_info | Map | III | Position | -1.44641 | Error | 6.5e-05 | |||
Positive | Positive_clone | B0244 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4431 | |||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00004433 | ||||||||
WBPaper00004518 | |||||||||
WBPaper00006469 | |||||||||
WBPaper00010811 | |||||||||
WBPaper00013484 | |||||||||
WBPaper00018329 | |||||||||
WBPaper00019367 | |||||||||
WBPaper00019564 | |||||||||
WBPaper00023830 | |||||||||
WBPaper00025141 | |||||||||
WBPaper00028559 | |||||||||
WBPaper00030754 | |||||||||
WBPaper00030837 | |||||||||
WBPaper00031936 | |||||||||
WBPaper00032252 | |||||||||
WBPaper00033045 | |||||||||
WBPaper00036308 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00039671 | |||||||||
WBPaper00045066 | |||||||||
WBPaper00046108 | |||||||||
WBPaper00049548 | |||||||||
WBPaper00051118 | |||||||||
WBPaper00052068 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00056066 | |||||||||
WBPaper00060134 | |||||||||
WBPaper00061890 | |||||||||
WBPaper00063729 | |||||||||
WBPaper00063855 | |||||||||
WBPaper00064591 | |||||||||
WBPaper00065945 | |||||||||
Remark | Sequence connection from [Zahn TA, Macmorris MA] | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |