WormBase Tree Display for Gene: WBGene00003247
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WBGene00003247 | SMap | S_parent | Sequence | ZC504 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||||
Name | CGC_name | mig-15 | Person_evidence | WBPerson261 | |||||
Sequence_name | ZC504.4 | ||||||||
Molecular_name (12) | |||||||||
Other_name | qid-7 | Person_evidence | WBPerson1157 | ||||||
qid-8 | Person_evidence | WBPerson1157 | |||||||
CELE_ZC504.4 | Accession_evidence | NDB | BX284606 | ||||||
Public_name | mig-15 | ||||||||
DB_info | Database (14) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 04 Nov 2014 12:25:34 | WBPerson2970 | Event | Acquires_merge | WBGene00004262 | ||||
Name_change | Other_name | qid-7 | |||||||
3 | 04 Nov 2014 12:27:29 | WBPerson2970 | Event | Acquires_merge | WBGene00004263 | ||||
Name_change | Other_name | qid-8 | |||||||
Acquires_merge | WBGene00004263 | ||||||||
WBGene00004262 | |||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mig | ||||||||
Allele (101) | |||||||||
Legacy_information | [Hedgecock EM] QL migration resembles QR. Pleiotropic defects in hypodermis. | ||||||||
[C.elegansII] rh148 : QL migration resembles QR. Pleiotropic defects in hypodermis. [CF] | |||||||||
Strain | WBStrain00024147 | ||||||||
WBStrain00024148 | |||||||||
WBStrain00028841 | |||||||||
WBStrain00028845 | |||||||||
WBStrain00028859 | |||||||||
WBStrain00004868 | |||||||||
WBStrain00004869 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (29) | |||||||||
Ortholog (41) | |||||||||
Paralog (27) | |||||||||
Structured_description | Concise_description | mig-15 encodes the C. elegans ortholog of vertebrate Nck-interacting kinase (NIK) which belongs to the STE20/germinal center kinase (GCK) family; MIG-15 is required for normal axon pathfinding, and to inhibit premature branching of commissures; RNAi of mig-15 and pat-3, which encodes a beta1A integrins, results in similar axonal defects, and mutations in ina-1, which encodes an alpha integrin chain, enhances the commissural phenotype of mig-15 mutations; MIG-15 also regulates multiple aspects Q cell behavior, including initial Q cell polarization (direction of lamellipodium extension) and maintenance of that polarity, as well as migration of the Q cells and their descendants; genetic mosaic analyses indicate that MIG-15 likely acts cell autonomously at least in AQR and PQR to regulate their migration; MIG-15 physically interacts with the cytoplasmic domain of the beta1A integrin, PAT-3; loss of mig-15 results in increased synapse number and synaptic tiling defect in DA neurons. | Paper_evidence | WBPaper00005218 | |||||
WBPaper00032247 | |||||||||
WBPaper00026842 | |||||||||
WBPaper00006110 | |||||||||
WBPaper00054962 | |||||||||
Person_evidence | WBPerson3718 | ||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson324 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 10 Oct 2018 00:00:00 | ||||||||
Automated_description | Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||||
Curator_confirmed | WBPerson38202 | ||||||||
Date_last_updated | 04 Jun 2018 00:00:00 | ||||||||
Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | |||||
DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||||
DOID:0081216 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30765) | ||||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||||
DOID:2043 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||||
Models_disease_asserted | WBDOannot00000550 | ||||||||
WBDOannot00000551 | |||||||||
WBDOannot00000555 | |||||||||
Molecular_info | Corresponding_CDS | ZC504.4a | |||||||
ZC504.4b | |||||||||
ZC504.4c | |||||||||
ZC504.4d | |||||||||
Corresponding_transcript (4) | |||||||||
Other_sequence (61) | |||||||||
Associated_feature (18) | |||||||||
Experimental_info | RNAi_result (21) | ||||||||
Expr_pattern | Expr1844 | ||||||||
Expr8961 | |||||||||
Expr1027934 | |||||||||
Expr1031541 | |||||||||
Expr1162414 | |||||||||
Expr2013563 | |||||||||
Expr2031796 | |||||||||
Drives_construct | WBCnstr00010481 | ||||||||
WBCnstr00013639 | |||||||||
WBCnstr00036163 | |||||||||
Construct_product | WBCnstr00010481 | ||||||||
WBCnstr00022525 | |||||||||
WBCnstr00036163 | |||||||||
Microarray_results (43) | |||||||||
Expression_cluster (104) | |||||||||
Interaction (111) | |||||||||
Anatomy_function | WBbtf0783 | ||||||||
WBbtf0784 | |||||||||
WBProcess | WBbiopr:00000082 | ||||||||
WBbiopr:00000107 | |||||||||
WBbiopr:00000111 | |||||||||
Map_info | Map | X | Position | 2.19018 | Error | 0.003698 | |||
Well_ordered | |||||||||
Positive | Positive_clone | ZC504 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 3293 | |||||||
3294 | |||||||||
3295 | |||||||||
3296 | |||||||||
4886 | |||||||||
4133 | |||||||||
Reference | WBPaper00005218 | ||||||||
WBPaper00006110 | |||||||||
WBPaper00010311 | |||||||||
WBPaper00011190 | |||||||||
WBPaper00015437 | |||||||||
WBPaper00017705 | |||||||||
WBPaper00017758 | |||||||||
WBPaper00018831 | |||||||||
WBPaper00022857 | |||||||||
WBPaper00026419 | |||||||||
WBPaper00026842 | |||||||||
WBPaper00027119 | |||||||||
WBPaper00027258 | |||||||||
WBPaper00027296 | |||||||||
WBPaper00027318 | |||||||||
WBPaper00028184 | |||||||||
WBPaper00029075 | |||||||||
WBPaper00030272 | |||||||||
WBPaper00030304 | |||||||||
WBPaper00030328 | |||||||||
WBPaper00030393 | |||||||||
WBPaper00030971 | |||||||||
WBPaper00032247 | |||||||||
WBPaper00032446 | |||||||||
WBPaper00032727 | |||||||||
WBPaper00032744 | |||||||||
WBPaper00034009 | |||||||||
WBPaper00034036 | |||||||||
WBPaper00035198 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00040226 | |||||||||
WBPaper00041078 | |||||||||
WBPaper00041230 | |||||||||
WBPaper00045272 | |||||||||
WBPaper00047342 | |||||||||
WBPaper00048179 | |||||||||
WBPaper00052120 | |||||||||
WBPaper00052634 | |||||||||
WBPaper00052762 | |||||||||
WBPaper00053450 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00057853 | |||||||||
WBPaper00058560 | |||||||||
WBPaper00058585 | |||||||||
WBPaper00060697 | |||||||||
WBPaper00063188 | |||||||||
Method | Gene |