WormBase Tree Display for Gene: WBGene00006875
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| WBGene00006875 | Evidence | Paper_evidence | WBPaper00005969 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T22C8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | vab-9 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T22C8.8 | ||||||||
| Molecular_name | T22C8.8 | ||||||||
| T22C8.8.1 | |||||||||
| CE32938 | |||||||||
| Other_name | CELE_T22C8.8 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | vab-9 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vab | ||||||||
| Reference_allele | WBVar00144274 | ||||||||
| Allele (27) | |||||||||
| Legacy_information | e1744 : slightly dumpy tail whip knobbed at all stages except adult male (adult male tail tip slightly swollen); variably Egl. ES3 (larvae) ME2. NA3 (e1775 e2016 : resemble e1744 slightly dumpier). | ||||||||
| See also e1744, e1775, e2016 | |||||||||
| [C.elegansII] e1744 : slightly dumpy, tail whip knobbed at all stages except adult male (adult male tail tip slightly swollen); variably Egl. ES3 (larvae) ME2. OA2: e1775, e2016 (resemble e1744, slightly dumpier). [Hodgkin 1974] | |||||||||
| Strain | WBStrain00004468 | ||||||||
| WBStrain00007740 | |||||||||
| WBStrain00007742 | |||||||||
| WBStrain00007743 | |||||||||
| WBStrain00031259 | |||||||||
| WBStrain00031254 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (10) | |||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization. | Paper_evidence | WBPaper00000608 | |||||
| WBPaper00004961 | |||||||||
| WBPaper00005946 | |||||||||
| WBPaper00005969 | |||||||||
| WBPaper00005975 | |||||||||
| WBPaper00012856 | |||||||||
| WBPaper00012883 | |||||||||
| WBPaper00018356 | |||||||||
| Person_evidence | WBPerson261 | ||||||||
| Curator_confirmed | WBPerson13481 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Involved in cell-cell adhesion; defense response to Gram-negative bacterium; and innate immune response. Located in cell junction. Expressed in epithelial cell; hypodermis; and nerve ring. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Is an ortholog of human TMEM47 (transmembrane protein 47). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112011 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17637) | ||||
| DOID:0050467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17637) | ||||||
| Molecular_info | Corresponding_CDS | T22C8.8 | |||||||
| Corresponding_CDS_history | T22C8.8:wp92 | ||||||||
| Corresponding_transcript | T22C8.8.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00073283 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00019018 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065106 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092872 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00035805 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053821 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2609 | ||||||||
| Expr2610 | |||||||||
| Expr1021012 | |||||||||
| Expr1032915 | |||||||||
| Expr1157368 | |||||||||
| Expr2017954 | |||||||||
| Expr2036090 | |||||||||
| Drives_construct | WBCnstr00000672 | ||||||||
| WBCnstr00034116 | |||||||||
| Construct_product | WBCnstr00034116 | ||||||||
| Antibody | WBAntibody00000653 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (142) | |||||||||
| Interaction (27) | |||||||||
| Map_info | Map | II | Position | 0.829738 | Error | 0.001028 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDf63 | |||||||
| mnDf68 | |||||||||
| mnDf69 | |||||||||
| Positive_clone | T22C8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 620 | |||||||
| 626 | |||||||||
| Multi_point (13) | |||||||||
| Pos_neg_data (17) | |||||||||
| Reference | WBPaper00000608 | ||||||||
| WBPaper00000715 | |||||||||
| WBPaper00001432 | |||||||||
| WBPaper00001750 | |||||||||
| WBPaper00005969 | |||||||||
| WBPaper00005975 | |||||||||
| WBPaper00012320 | |||||||||
| WBPaper00012425 | |||||||||
| WBPaper00013733 | |||||||||
| WBPaper00014137 | |||||||||
| WBPaper00014209 | |||||||||
| WBPaper00014619 | |||||||||
| WBPaper00016158 | |||||||||
| WBPaper00017734 | |||||||||
| WBPaper00018043 | |||||||||
| WBPaper00018687 | |||||||||
| WBPaper00020813 | |||||||||
| WBPaper00022839 | |||||||||
| WBPaper00023652 | |||||||||
| WBPaper00025995 | |||||||||
| WBPaper00027244 | |||||||||
| WBPaper00027245 | |||||||||
| WBPaper00028482 | |||||||||
| WBPaper00029033 | |||||||||
| WBPaper00030659 | |||||||||
| WBPaper00032115 | |||||||||
| WBPaper00032446 | |||||||||
| WBPaper00035002 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00039831 | |||||||||
| WBPaper00041549 | |||||||||
| WBPaper00042769 | |||||||||
| WBPaper00045034 | |||||||||
| WBPaper00046645 | |||||||||
| WBPaper00049452 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056902 | |||||||||
| WBPaper00065085 | |||||||||
| Method | Gene |
